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Nature Communications has been striving to support Early Career Researchers (ECRs) through different pilot schemes including the peer review mentoring programs and co-review mentoring initiative. The 2nd Rising Stars workshop, held at the Henry Royce Institute on the 9th of February, 2024, aims to celebrate and support rising stars within underrepresented groups in Science, Technology, Engineering and Mathematics (STEM) subjects and this greatly aligns with the aspirations in our journal. In this conversation, the experiences and advice shared by representatives from various disciplines in the workshop are translated to a wider audience in Nature Communications. Dr Alex Ramadan (Lecturer at the University of Sheffield), Dr Lucy Whalley (Assistant Professor at Northumbria University), Dr Maddison Coke (Senior Experimental Officer at the University of Manchester), and Dr Yi Liu (Lecturer at Loughborough University) discuss the opportunities and challenges they face towards their career with work-life balance, family and caring responsibility, and diversity and inclusion in their workplace, and share their experiences on how mentorship supports their personal and professional growth.
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To build pathways to constructive and engaging peer review for the next generation of scientists, we invite all our reviewers to co-review with an Early Career Researcher in their group and let us know. We will ensure ECRs are recognised for their contribution.
Africa is undergoing a demographic transition1 that has led to significant reductions in the number of individuals living in extreme poverty, and to positive shifts in related health outcomes, across its diverse populations2. Building on these successes requires a consideration of intersecting factors that impact health metrics, which is the focus of the United Nations Sustainable Development Goals3. To support researchers in their efforts towards reaching these goals, Nature Communications, Communications Medicine and Scientific Reports invite submissions of papers that advance our understanding of all aspects of health in Africa.
On 14 May, in collaboration with Communications Medicine, we will host a webinar on adoptive cell therapies for cancer. Panellists will discuss developments and challenges in the field (including introduction on tumour-infiltrating lymphocyte therapy, CAR-T cells, CAR-natural killer cells and CAR-macrophages) for cancer treatment. The event will be live-streamed but a recording will be available.
Nature Communications, Communications Medicine and Scientific Reports are launching an open call for papers to support and showcase research related to all aspects of health in Africa. We aim to promote high-quality research that advances our understanding of health issues in Africa, and advocates for better healthcare on the continent in line with the United Nations 2030 Agenda for SDGs.
A radiation damage cycle in X-ray-ionized solvated Mg ions is reported by the authors leading to production of water radicals and low-energy electrons. The Mg ion ends in its initial state quickly and can restart the cycle, multiplying the local damage.
Biaryl compounds with an axial chirality are valuable architectures but few methods have been developed for the construction of bridged biaryls, a subclass of these compounds that bear a tether to connect the two arenes and form a medium-sized ring. Here, the authors design a Co/SPDO-catalyzed aerobic oxidative coupling/desymmetrization sequence of prochiral phenols for the enantioselective synthesis of biaxial bridged m-terphenyls embedded in an azocane.
A comprehensive understanding of the transient characteristics in solid oxide cells is crucial when integrated with intermittent renewable energy. Here, authors reveal expressions for two general characteristic times quantifying transient phenomena due to heat and mass transfer lags in SOCs.
The 2021 Pacific Northwest Heatwave challenged standard attribution methods. The authors use a weather model that predicted the event to quantify human impact on the heat, suggesting that such models could be used broadly to assess changing weather risk.
The oxidation of sulfur dioxide to sulfate by hydrogen peroxide in aerosol water significantly impacts global continental regions. Abating oxidants can facilitate the benefit of sulfur dioxide reduction and positive feedback in sulfate mitigation.
Attributing spatially heterogeneous heat stress trends to water vapor pressure changes driven by climate change-induced rapid warming in high-latitudes of East Asia, the authors predict widespread and uniform future heat stress in eastern China.
Microbial degradation and biosynthesis of fluorinated compounds is a field of increasing importance, but is hampered by the significant toxicity of fluoride. Here authors discuss emerging ideas on microbial defluorination/fluorination and fluoride resistance mechanisms, providing guidance on how this knowledge can guide future bioengineering approaches.
Dbr1 exhibits debranching specificity and effect on splicing. Here the authors combine co-immunoprecipitation, RNA binding and lariat analysis and suggest a role for Dbr1 interactor AQR in intron recycling. Dbr1 depletion leads to increased dwell time of spliceosome on excised lariats.
In this study the authors present the Thogoto virus polymerase cryo-EM structures and reveal unique RNA synthesis mechanisms among orthomyxoviruses. RNA synthesis by Thogoto virus polymerase is shown to be weakly dependent on the host factors ANP32A/B/E in human cells in contrast to influenza viruses.
African swine fever virus is the sole mammalian-infecting virus encoding a type II topoisomerases (pP1192R). The authors present pP1192R structures in different states, illustrating the enzymatic mechanisms of viral type II topoisomerases.
Mosquito biting preferences and their impact on malaria transmission are not well understood. Here, the authors report findings from a longitudinal cohort study in Western Kenya which show that males aged 5-15 years tend to be bitten the most, and infectious mosquitoes appear to be more likely to bite infected individuals.
The authors found that GPi circadian rhythms varied across individuals, with neural activity mainly decreasing at night but sometimes increasing. GPi circadian rhythms were frequency band-dependent and were modulated by the use of extended-release levodopa medication at night.
Accurate non-invasive biomarkers to diagnose MASLD-related fibrosis are urgently needed. Here the authors show a disease mechanism-related blood-based biomarker panel consisting of three biomarkers which is able to accurately identify MASLD patients with mild or advanced hepatic fibrosis.
Resistance to glucocorticoids (GC) is a major obstacle for the treatment of pediatric B-cell acute lymphoblastic leukemia (B-ALL). Here, the authors report that GC-triggered CXCR4 internalization promotes a phospholipase C (PLC)-mediated cell survival pathway, driving GC resistance in B-ALL.
Harnessing the potential of considerable food security efforts requires the ability to translate them into commercial applications. In this Perspective, the author explores the alternative protein source start-up landscape.
Decentralized management of distributed energy sources for lower energy costs is of high interest. Here, authors show how privacy and security concerns are addressed under a decentralization framework through blockchain and parallelizable algorithms.
Zhao P.J. and his colleagues uncover spatial directionality of urban mobility by using new metrics of anisotropy and centripetality. They find monocentric cities have longer commutes with city expansion, while polycentric cities maintain consistent commuting patterns.
People learn by observing others and from personal experience, but which strategy they favor varies. Here, the authors show that while some people dynamically arbitrate and switch to the strategy that is most reliable, others preferentially use one or a fixed mixture of strategies.
In this work, authors develop a high-efficiency micro-combined heat and power system powered by an opposed-piston engine which enables simultaneous generation of electricity and heating to residential homes or light commercial buildings. The design is shown to be particularly effective for colder climates.
Recent seismological studies challenge the traditional view that the interface between the core and mantle is a straightforward discontinuity. As seismology is pushed to its observational limits, a complex - potentially compositionally layered - region between the core and mantle is emerging.
Shigella, an important human pathogen, can secrete effector proteins to invade host cells and evade mechanisms of cell-autonomous immunity. In a new manuscript published in Nature Communications, Xian et al. report that the Shigella kinase effector OspG promotes the ubiquitination of septin cytoskeletal proteins to evade cage entrapment. 152ee80cbc
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