Illustration by Alex Cagan
Illustration by Alex Cagan
I am a postdoctoral researcher for the Centre for Genomics and Computational Biology, at the Barts Cancer Institute at Queen Mary University of London. My research concerns the mathematical study of genetic heterogeneity in human tissues, with the wider goal of better understanding and quantifying cell behaviours in complex tissue architectures, and ultimately improving our understanding of oncogenesis and early tumour development. To this end I investigate mathematical properties of somatic evolution in the context of both cancerous and healthy tissue. I use methods from population genetics, dynamical systems, stochastic processes, and numerical analysis, with a focus on the construction and solution of SDE and SPDE systems. Because the immeasurable complexity of biology deprives us from understanding everything all at once, I believe the most meaningful and useful models come from
THE ARTFUL USE OF RANDOMNESS
Moeller, M. E., Mon Père, N. V., Werner, B. & Huang W. (2024) Measures of genetic diversification in somatic tissues at bulk and single-cell resolution eLife 12:RP89780 https://doi.org/10.7554/eLife.89780.3
Mon Père, N. V., de Buyl, P., & de Buyl, S. (2022). Brownian motion in a growing population of ballistic particles. Physical Review E, 105(3), 034133. https://10.1103/PhysRevE.105.034133
Mon Père, N. V., Lenaerts, T., Pacheco, J. M., & Dingli, D. (2021). Multistage feedback-driven compartmental dynamics of hematopoiesis. IScience, 24(4). https://doi.org/10.1016/j.isci.2021.102326