Publications
Research Articles
Chalençon L, Midroit M, Athanassi A, Thevenet M, Breton M, Forest J, Richard M, Didier A, Mandairon N. Age-related differences in perception and coding of attractive odorants in mice. Neurobiol Aging. 2024 May;137:8-18. doi: 10.1016/j.neurobiolaging.2024.02.003.
Terrier C, Greco-Vuilloud J, Cavelius M, Thevenet M, Mandairon N, Didier A, Richard M. Long-term olfactory enrichment promotes non-olfactory cognition, noradrenergic plasticity and remodeling of brain functional connectivity in older mice. Neurobiol Aging. 2024 Apr;136:133-156. doi: 10.1016/j.neurobiolaging.2024.01.011.
Neige C, Imbert L, Dumas M, Athanassi A, Thévenet M, Mandairon N, Brunelin J. Combining a Breath-Synchronized Olfactometer with Brain Simulation to Study the Impact of Odors on Corticospinal Excitability and Effective Connectivity. J Vis Exp. 2024 Jan 19;(203). doi: 10.3791/65714. PMID: 38314795.
Athanassi A, Breton M, Chalençon L, Brunelin J, Didier A, Bath K, Mandairon N. Chronic unpredictable mild stress alters odor hedonics and adult olfactory neurogenesis in mice. Front Neurosci. 2023 Aug 3;17:1224941. doi: 10.3389/fnins.2023.1224941.
Greco-Vuilloud J, Midroit M, Terrier C, Forest J, Sacquet J, Mandairon N, Didier A, Richard M. 12 months is a pivotal age for olfactory perceptual learning and its underlying neuronal plasticity in aging mice. Neurobiol Aging. 2022 Jun;114:73-83. doi: 10.1016/j.neurobiolaging.2022.03.003.
Psomiades M, Mondino M, Galvão F, Mandairon N, Nourredine M, Suaud-Chagny MF, Brunelin J. Serum Mature BDNF Level Is Associated with Remission Following ECT in Treatment-Resistant Depression. Brain Sci. 2022 Jan 18;12(2):126. doi: 10.3390/brainsci12020126.
Chalençon L, Thevenet M, Noury N, Bensafi M, Mandairon N. Identification of new behavioral parameters to assess odorant hedonic value in humans: A naturalistic approach. J Neurosci Methods. 2022 Jan 15;366:109422. doi: 10.1016/j.jneumeth.2021.109422.
Athanassi A, Dorado Doncel R, Bath KG, Mandairon N. Relationship between depression and olfactory sensory function: a review. Chem Senses. 2021 Jan 1;46:bjab044. doi: 10.1093/chemse/bjab044.
Adam O, Psomiades M, Rey R, Mandairon N, Suaud-Chagny MF, Mondino M, Brunelin J. Frontotemporal Transcranial Direct Current Stimulation Decreases Serum Mature Brain-Derived Neurotrophic Factor in Schizophrenia. Brain Sci. 2021 May 19;11(5):662.doi: 10.3390/brainsci11050662 .
Midroit M, Chalençon L, Renier N, Milton A, Thevenet M, Sacquet J, Breton M, Forest J, Noury N, Richard M, Raineteau O, Ferdenzi C, Fournel A, Wesson DW, Bensafi M, didier A and Mandairon N. Neural processing of the reward value of pleasant odorants. Current Biology. 2021 Apr 26;31(8):1592-1605.e9. doi: 10.1016/j.cub.2021.01.066.
Kermen F, Mandairon N, Chalençon L. Odor hedonics coding in the vertebrate olfactory bulb. Cell Tissue Res. 2021 Jan;383(1):485-493. doi: 10.1007/s00441-020-03372-w.
Linster C, Midroit M, Forest J, Thennaisie Y, Cho C, Richard M, Didier M, Mandairon N. Noradrenergic Activity in the Olfactory Bulb Is a Key Element for the Stability of Olfactory Memory. J Neurosci. 2020 Nov 25; 40(48):9260-9271. DOI: 10.1523/JNEUROSCI.1769-20.2020.
Forest J, Chalençon L, Midroit M, Terrier C, Caillé I, Sacquet J, Benetollo C, Martin K, Richard M, Didier A, Mandairon N. Role of Adult-Born Versus Preexisting Neurons Born at P0 in Olfactory Perception in a Complex Olfactory Environment in Mice. Cerebral Cortex. 2020 Mar 21;30(2):534-549. doi: 10.1093/cercor/bhz105.
Didier A, Mandairon N. [Short-term availability of adult-born neurons for memory encoding]. Med Sci (Paris). 2020 Aug-Sep;36(8-9):706-708. doi: 10.1051/medsci/2020142. Epub 2020 Aug 21.
Forest J, Moreno M, Cavelius M, Chalençon L, Ziessel A, Sacquet J, Richard M, Didier A, Mandairon N. Short-term availability of adult-born neurons for memory encoding. Nat Commun. 2019 Dec 6;10(1):5609. doi: 10.1038/s41467-019-13521-7.
Schilit Nitenson A, Manzano Nieves G, Poeta DL, Bahar R, Rachofsky C, Mandairon N, Bath KG. Acetylcholine Regulates Olfactory Perceptual Learning through Effects on Adult Neurogenesis. iScience. 2019 Dec 20;22:544-556. doi: 10.1016/j.isci.2019.11.016. Epub 2019 Nov 14.
Ballanger B, Bath KG, Mandairon N. Odorants: a tool to provide nonpharmacological intervention to reduce anxiety during normal and pathological aging. Neurobiol Aging. 2019 Oct;82:18-29. doi: 10.1016/j.neurobiolaging.2019.06.007. Epub 2019 Jul 3.
Midroit M, Thevenet M, Fournel A, Sacquet J, Bensafi M, Breton M, Chalençon L, Cavelius M, Didier A, Mandairon N. Non-imaged based method for matching brains in a common anatomical space for cellular imagery. J Neurosci Methods. 2018 Jul 1;304:136-145. doi: 10.1016/j.jneumeth.2018.04.004. Epub 2018 Apr 22.
Jagetia S, Milton AJ, Stetzik LA, Liu S, Pai K, Arakawa K, Mandairon N, Wesson DW. Inter- and intra-mouse variability in odor preferences revealed in an olfactory multiple-choice test. Behav Neurosci. 2018 Apr;132(2):88-98. doi: 10.1037/bne0000233. Epub 2018 Mar 1.
Mandairon N., Kuczewski N., Kermen F., Forest J., Midroit M., Richard M., Thevenet M., Sacquet J., Linster C and Didier A. Opposite regulation of inhibition by adult-born granule cells in response to implicit versus explicit olfactory learning. Elife. 2018 Feb 28;7. pii: e34976. doi: 10.7554/eLife.34976.
Kermen, F., Midroit, M., Kuczewski, N., Forest, J., Thevenet, M., Sacquet, J., Benetollo, C., Richard, M., Didier, A.*, and Mandairon, N.* (2016) Topographical representation of odor hedonics in the olfactory bulb. Nat Neurosci 19, 876-878. doi: 10.1038/nn.4317. Epub 2016 Jun 6.
Daroles, L., Gribaudo, S., Doulazmi, M., Scotto-Lomassese, S., Dubacq, C., Mandairon, N., Greer, C. A., Didier, A., Trembleau, A., and Caille, I. (2016) Fragile X Mental Retardation Protein and Dendritic Local Translation of the Alpha Subunit of the Calcium/Calmodulin-Dependent Kinase II Messenger RNA Are Required for the Structural Plasticity Underlying Olfactory Learning. Biol Psychiatry 80, 149-159. doi: 10.1016/j.biopsych.2015.07.023. Epub 2015 Aug 7.
Vinera, J., Kermen, F., Sacquet, J., Didier, A., Mandairon, N., and Richard, M. (2015) Olfactory perceptual learning requires action of noradrenaline in the olfactory bulb: comparison with olfactory associative learning. Learn Mem 22, 192-196. doi: 10.1101/lm.036608.114. Print 2015 Mar.
Mandairon, N., Kermen, F., Charpentier, C., Sacquet, J., Linster, C., and Didier, A. (2014) Context-driven activation of odor representations in the absence of olfactory stimuli in the olfactory bulb and piriform cortex. Front Behav Neurosci 8, 138. doi: 10.3389/fnbeh.2014.00138. eCollection 2014.
Moreno, M., Richard, M., Landrein, B., Sacquet, J., Didier, A., and Mandairon, N. (2014) Alteration of olfactory perceptual learning and its cellular basis in aged mice. Neurobiol Aging 35, 680-691. doi: 10.1016/j.neurobiolaging.2013.08.034. Epub 2013 Oct.
Moreno, M. M., Bath, K., Kuczewski, N., Sacquet, J., Didier, A., and Mandairon, N. (2012) Action of the noradrenergic system on adult-born cells is required for olfactory learning in mice. J Neurosci 32, 3748-3758. doi: 10.1523/JNEUROSCI.6335-11.2012.
Kermen, F., Chakirian, A., Sezille, C., Joussain, P., Le Goff, G., Ziessel, A., Chastrette, M., Mandairon, N., Didier, A., Rouby, C., and Bensafi, M. (2011) Molecular complexity determines the number of olfactory notes and the pleasantness of smells. Sci Rep 1, 206. doi: 10.1038/srep00206. Epub 2011 Dec 22. Erratum in: Sci Rep. 2013;3:1132.
Gely-Pernot, A., Coronas, V., Harnois, T., Prestoz, L., Mandairon, N., Didier, A., Berjeaud, J. M., Monvoisin, A., Bourmeyster, N., De Frutos, P. G., Philippe, M., and Benzakour, O. (2012) An endogenous vitamin K-dependent mechanism regulates cell proliferation in the brain subventricular stem cell niche. Stem Cells 30, 719-731. doi: 10.1002/stem.1045.
Sultan, S., Rey, N., Sacquet, J., Mandairon, N., and Didier, A. (2011) Newborn neurons in the olfactory bulb selected for long-term survival through olfactory learning are prematurely suppressed when the olfactory memory is erased. J Neurosci 31, 14893-14898. doi: 10.1523/JNEUROSCI.3677-11.2011.
Mandairon, N.*, Sultan, S.*, Nouvian, M., Sacquet, J., and Didier, A. (2011) Involvement of newborn neurons in olfactory associative learning? The operant or non-operant component of the task makes all the difference. J Neurosci 31, 12455-12460. doi: 10.1523/JNEUROSCI.2919-11.2011.
Sultan, S., Lefort, J. M., Sacquet, J., Mandairon, N., and Didier, A. (2011) Acquisition of an olfactory associative task triggers a regionalized down-regulation of adult born neuron cell death. Front Neurosci 5, 52. doi: 10.3389/fnins.2011.00052. eCollection 2011.
Mandairon, N., and Didier, A. (2010) The brain's fight against aging. Proc Natl Acad Sci U S A 107, 15316-15317. doi: 10.1073/pnas.1010574107. Epub 2010 Aug 24. No
Kermen, F., Sultan, S., Sacquet, J., Mandairon, N., and Didier, A. (2010) Consolidation of an olfactory memory trace in the olfactory bulb is required for learning-induced survival of adult-born neurons and long-term memory. PLoS One 5, e12118. doi: 10.1371/journal.pone.0012118.
Haddad, R., Weiss, T., Khan, R., Nadler, B., Mandairon, N., Bensafi, M., Schneidman, E., and Sobel, N. (2010) Global features of neural activity in the olfactory system form a parallel code that predicts olfactory behavior and perception. J Neurosci 30, 9017-9026. doi: 10.1523/JNEUROSCI.0398-10.2010.
Sultan, S., Mandairon, N., Kermen, F., Garcia, S., Sacquet, J., and Didier, A. (2010) Learning-dependent neurogenesis in the olfactory bulb determines long-term olfactory memory. FASEB J 24, 2355-2363. doi: 10.1096/fj.09-151456. Epub 2010 Mar 9.
Mandairon, N., Peace, S. T., Boudadi, K., Boxhorn, C. E., Narla, V. A., Suffis, S. D., and Cleland, T. A. (2011) Compensatory responses to age-related decline in odor quality acuity: cholinergic neuromodulation and olfactory enrichment. Neurobiol Aging 32, 2254-2265. doi: 10.1016/j.neurobiolaging.2009.12.024. Epub 2010 Jan 15.
Moreno, M. M., Linster, C., Escanilla, O., Sacquet, J., Didier, A., and Mandairon, N. (2009) Olfactory perceptual learning requires adult neurogenesis. Proc Natl Acad Sci U S A 106, 17980-17985. doi: 10.1073/pnas.0907063106. Epub 2009 Oct 7.
Busto, G. U., Elie, J. E., Kermen, F., Garcia, S., Sacquet, J., Jourdan, F., Marcel, D., Mandairon, N., and Didier, A. (2009) Expression of Zif268 in the granule cell layer of the adult mouse olfactory bulb is modulated by experience. Eur J Neurosci 29, 1431-1439. doi: 10.1111/j.1460-9568.2009.06689.x. Epub 2009 Mar 23.
Mandairon, N., Sultan, S., Rey, N., Kermen, F., Moreno, M., Busto, G., Farget, V., Messaoudi, B., Thevenet, M., and Didier, A. (2009) A computer-assisted odorized hole-board for testing olfactory perception in mice. J Neurosci Methods 180, 296-303. doi: 10.1016/j.jneumeth.2009.04.008. Epub 2009 Apr 19.
Mandairon, N., and Linster, C. (2009) Odor perception and olfactory bulb plasticity in adult mammals. J Neurophysiol 101, 2204-2209. doi: 10.1152/jn.00076.2009. Epub 2009 Mar 4. Review.
Mandairon, N., Poncelet, J., Bensafi, M., and Didier, A. (2009) Humans and mice express similar olfactory preferences. PLoS One 4, e4209. doi: 10.1371/journal.pone.0004209. Epub 2009 Jan 16.
Escanilla, O., Mandairon, N., and Linster, C. (2008) Odor-reward learning and enrichment have similar effects on odor perception. Physiol Behav 94, 621-626. doi: 10.1016/j.physbeh.2008.03.008. Epub 2008 Mar 28.
Mandairon, N., Didier, A., and Linster, C. (2008) Odor enrichment increases interneurons responsiveness in spatially defined regions of the olfactory bulb correlated with perception. Neurobiol Learn Mem 90, 178-184. doi: 10.1016/j.nlm.2008.02.008. Epub 2008 Apr 10.
Mandairon, N., Peace, S., Karnow, A., Kim, J., Ennis, M., and Linster, C. (2008) Noradrenergic modulation in the olfactory bulb influences spontaneous and reward-motivated discrimination, but not the formation of habituation memory. Eur J Neurosci 27, 1210-1219. doi: 10.1111/j.1460-9568.2008.06101.x.
Bath, K. G., Mandairon, N., Jing, D., Rajagopal, R., Kapoor, R., Chen, Z. Y., Khan, T., Proenca, C. C., Kraemer, R., Cleland, T. A., Hempstead, B. L., Chao, M. V., and Lee, F. S. (2008) Variant brain-derived neurotrophic factor (Val66Met) alters adult olfactory bulb neurogenesis and spontaneous olfactory discrimination. J Neurosci 28, 2383-2393. doi: 10.1523/JNEUROSCI.4387-07.2008.
Guerin, D., Sacquet, J., Mandairon, N., Jourdan, F., and Didier, A. (2009) Early locus coeruleus degeneration and olfactory dysfunctions in Tg2576 mice. Neurobiol Aging 30, 272-283.
Mandairon, N., Sacquet, J., Garcia, S., Ravel, N., Jourdan, F., and Didier, A. (2006) Neurogenic correlates of an olfactory discrimination task in the adult olfactory bulb. Eur J Neurosci 24, 3578-3588
Mandairon, N., Ferretti, C. J., Stack, C. M., Rubin, D. B., Cleland, T. A., and Linster, C. (2006) Cholinergic modulation in the olfactory bulb influences spontaneous olfactory discrimination in adult rats. Eur J Neurosci 24, 3234-3244
Mandairon, N., Stack, C., Kiselycznyk, C., and Linster, C. (2006) Broad activation of the olfactory bulb produces long-lasting changes in odor perception. Proc Natl Acad Sci U S A 103, 13543-13548
Mandairon, N., Stack, C., and Linster, C. (2006) Olfactory enrichment improves the recognition of individual components in mixtures. Physiol Behav 89, 379-384
Mandairon, N., Sacquet, J., Jourdan, F., and Didier, A. (2006) Long-term fate and distribution of newborn cells in the adult mouse olfactory bulb: Influences of olfactory deprivation. Neuroscience 141, 443-451
Mandairon, N., Stack, C., Kiselycznyk, C., and Linster, C. (2006) Enrichment to odors improves olfactory discrimination in adult rats. Behav Neurosci 120, 173-179
Mandairon, N., Jourdan, F., and Didier, A. (2003) Deprivation of sensory inputs to the olfactory bulb up-regulates cell death and proliferation in the subventricular zone of adult mice. Neuroscience 119, 507-516