The Ōtsutsuki Clan (大筒木一族, Ōtsutsuki Ichizoku) is an ancient clan of horned human-like creatures known as celestial beings (天津人, amatsubito), and also described as aliens (宇宙人, uchūjin), and revered as equivalent to gods. As a parasitic species, they have spent thousands of years traversing through the cosmos in order to carry out the Ōtsutsuki Will (大筒木の意志, Ōtsutsuki no Ishi), a doctrine which dictates that clan members consume the life energy and genetic material of other worlds in order to continuously evolve, with the ultimate goal of attaining godhood.

After the arrival of Kaguya on Earth a millennium ago, the Ōtsutsuki began having a lasting influence on the human population, notably starting the history of shinobi.