Uncoupling of SERCA pump activity by Sarcolipin as the basis for muscle non-shivering thermogenesis. (2019) Bal NC, Periasamy M. Royal Society Philosophical Transactions B. 375(1793): 20190135. Corresponding author.
Epigenetic mechanisms in regulation of adaptive thermogenesis in skeletal muscle. (2019) Sahu B, Pani S, Swalsingh G, Bal NC. Frontiers in Endocrinology. 10. 517. Corresponding author.
First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers. (2019) Chakravarty H, Bal C, Yadav M, Jena N, Bal NC, Sharon A. ACS Omega 4, 7, 11508-11514 doi: 10.1021/acsomega.9b01113. Corresponding author.
Epiregulin induces leptin secretion and energy expenditure in high-fat diet-fed mice. (2018) Yasmeen R, Shen Q, Lee A, Leung JH, Kowdley D, DiSilvestro DJ, Xu L, Yang K, Maiseyeu A, Bal NC, Periasamy M, Fadda P, Ziouzenkova O. Journal of Endocrinology. 239(3):377-388. doi: 10.1530/JOE-18-0289.
The Role of Sarcolipin in Muscle Non-shivering Thermogenesis. (2018) Bal NC, Sahoo SK, Maurya SK, Periasamy M. Frontiers in Physiology. 9:1217. doi: 10.3389/fphys.2018.01217. Corresponding author.
Identification of new inhibitors against human Great wall kinase using in silico approaches. (2018) Ammarah U, Kumar A, Pal R, Bal NC, Misra G. Scientific Reports. 8(1):4894. doi: 10.1038/s41598-018-23246-0.
Mild cold induced thermogenesis: are BAT and skeletal muscle synergistic partners? (2017) Bal NC, Maurya SK, Pani S, Sethy C, Banerjee A, Das S, Patnaik S, Kundu CN. Bioscience Reports. 37(5). doi: 10.1042/BSR20171087. Corresponding author.
Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. (2017) Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA and Periasamy M. Journal of Biological Chemistry. 292(40):16616-16625. Corresponding Author.
Role of SERCA pump in muscle thermogenesis and metabolism. Periasamy M, Maurya SK, Sahoo SK, Singh S, Reis FCG and Bal NC. (2017) Comprehensive Physiology. 7(3):879-890.
Stress-responsive HILPDA is necessary for thermoregulation during fasting. VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia AJ, Denko NC, Papandreou I. (2017) Journal of Endocrinology. 235(1):27-38.
Sarcolipin: key thermogenic and metabolic regulator in skeletal muscle. Pant M, Bal NC and Periasamy M. (2016) Trends in Endocrinology & Metabolism. 27(12):881-892.
Increased reliance on muscle based thermogenesis upon acute minimization of brown adipose tissue function. (2016) Bal NC, Maurya SK, Singh S, Wehrens XH, and Periasamy M. Journal of Biological Chemistry. 291(33): 17247-57. Corresponding Author.
Sarcolipin and Uncoupling Protein 1 play distinct roles in diet induced thermogenesis and do not compensate for one another. (2016) Rowland LA, Maurya SK, Bal NC, Kozak LP and Periasamy M. Obesity. 24(7):1430-3.
The N Terminus of Sarcolipin Plays an Important Role in Uncoupling Sarco-endoplasmic Reticulum Ca2+-ATPase (SERCA) ATP Hydrolysis from Ca2+ Transport. Sahoo SK, Shaikh SA, Sopariwala DH, Bal NC, Bruhn DS, Kopec W, Khandelia H, and Periasamy M. (2015) Journal of Biological Chemistry. 290(22): 14057-67.
Uncoupling Protein 1 and Sarcolipin are required to maintain optimal thermogenesis and loss of both systems compromises survival of mice under cold stress. Rowland LA, Bal NC, Kozak LP and Periasamy M. (2015) Journal of Biological Chemistry. 290(19): 12282-9.
Sarcolipin is a key determinant of basal metabolic rate and its overexpression enhances energy expenditure and resistance against diet induced obesity. Maurya SK, Bal NC, Saporiwala DH, Pant M, Rowland LA, Shaikh SA and Periasamy M. (2015) Journal of Biological Chemistry. 290(17): 10840-9.
Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy. Pant M, Sopariwala DH, Bal NC, Lowe J, Delfín DA, Rafael-Fortney J, Periasamy M. (2015) PLoS One. 10(4):e0123875.
The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrin. Bal NC, Jena N, Chakravarty H, Kumar A, Chi M, Balaraju T, Rawale SV, Rawale JS, Sharon A, and Periasamy M. (2015) Biopolymers. 103(1): 15-22. Corresponding Author
The role of skeletal muscle-based thermogenic mechanisms in vertebrate endothermy. Rowland LA, Bal NC, and Periasamy M. (2015) Biological Reviews. 90(4):1279-97. Corresponding Author
Malignant hyperthermia: to buffer or not to buffer. Pant M, Sopariwala DH, Bal NC. (2014) Journal of Physiology. 592(5):827-8
Functional interaction between calsequestrin and ryanodine receptor in the heart. Gaburjakova M*, Bal NC*, Gaburjakova J, and Periasamy M. (2013) Cellular & Molecular Life Sciences. 70(16): 2935-45. *Equal contribution.
Identification of calcium binding sites on calsequestrin 1 and their implications for polymerization. Kumar A, Chakravarty H, Bal NC, Balaraju T, Bal C, Ernico P, Periasamy M, and Sharon A. (2013) Molecular Biosystems. 9(7): 1949-1957. Corresponding Author.
Sarcolipin trumps β-adrenergic receptor signaling as the favored mechanism for muscle-based diet-induced thermogenesis. Bombardier E, Smith IC, Gamu D, Fajardo VA, Vigna C, Sayer RA, Gupta SC, Bal NC, Periasamy M, Tupling AR. (2013) FASEB Journal. 27(9):3871-8.
Aromatic interaction profile to understand the molecular basis of raltegravir resistance. T Balaraju, A Kumar, C Bal, D Chattopadhyay, N Jena, NC Bal, A Sharon (2013) Structural Chemistry 24 (5), 1499-1512
Targeting peroxisome proliferator-activated receptor gamma for generation of antidiabetic drug. Karak M, Bal NC, Bal C, Sharon A. (2013) Current Diabetes Reviews. 9(4):275-85.
Sarcolipin interaction with SERCA is distinct from Phospholamban; only sarcolipin can promote uncoupling of the SERCA pump. Sahoo SK, Saporiwala DH, Shaikh SA, Bal NC, and Periasamy M. (2013) Journal of Biological Chemistry. 288(10): 6881-9.
High gender specific susceptibility to curare- a neuro muscular blocking agent. Maurya SK, Periasamy M and Bal NC. (2013) Biological Research. 46: 85-88. Corresponding Author.
Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals. Bal NC, Maurya SK, Saporiwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Bombardier E, Goonasekera SA, Tupling AR, Molkentin JD and Periasamy M. (2012) Nature Medicine. 18(10):1575-9.
Increased incidence of heatstroke in India: Is there a genetic predisposition? NC Bal, M Pant, SK Maurya, M Periasamy. (2012) GERF Bulletin of Biosciences. 3(1): 7-17. Corresponding Author.
Protein kinase Cbeta deficiency attenuates obesity syndrome of ob/ob mice by promoting white adipose tissue remodeling. Huang W, Bansode RR, Bal NC, Mehta M and Mehta KD. (2012) Journal of Lipid Research. 53(3):368-78.
IKKα and Alternative NF-κB Directly Regulate PGC-1β to Promote Oxidative Muscle. Bakkar N, Ladner K, Canan BD, Liyanarachchi S, Bal NC, Pant M, Periasamy M, Li Q, Janssen PML and Guttridge DC. (2012) Journal of Cell Biology. 196(4):497-511.
Probing cationic selectivity of Cardiac Calsequestrin and its CPVT mutants. Bal NC, Jena N, Saporiwala D, Balaraju T, Shaikh S, Bal C, Sharon A, Gyorke S and Periasamy M. (2011) Biochemical Journal. 435(2): 391-399. (Corresponding Author)
The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerization. Bal NC, Sharon A, Gupta SC, Jena N, Shaikh S, Gyorke S and Periasamy M. (2010) Journal of Biological Chemistry. 285(22): 17188-17196.
The calsequestrin mutation CASQ2D307H does not affect protein stability and targeting to the jSR but compromises its dynamic regulation of calcium buffering. Kalyanasundaram A, Bal NC, Franzini-Armstrong C, Knollmann BC and Periasamy M. (2010) Journal of Biological Chemistry. 285(5): 3076-3083.
Indian diet: Implications in recent explosion in insulin resistance and metabolic syndromes in India. Maurya SK and Bal NC. (2010) GERF Bulletin of Biosciences. 1(1): 25-36.
Pulmonary artery banding alters the expression of Ca2+ transport proteins in the right atrium in rabbits. Gupta SC, Varian KD, Bal NC, Abraham JL, Periasamy M, Janssen PM. (2009) Am J Physiol Heart Circ Physiol. 296(6): H1933-1939.
Characterization of peptidyl-tRNA hydrolase coded by open reading frame Rv1014c of Mycobacterium tuberculosis H37Rv. Bal NC, Agarwal H, Meher AK and Arora A. (2007) Biological Chemistry. 388(5): 467-479.
Ligand based Virtual Screening and Biological Evaluation of Potent and Selective Inhibitors of Chorismate Mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv. Agrawal H, Kumar A, Bal NC, Siddiqi MI and Arora A. (2007) Bioorg Med Chem Lett. 17(11): 3053-3058.
Mycobacterium tuberculosis H37Rv ESAT-6-CFP-10 complex formation confers thermodynamic and biochemical stability. Meher AK, Bal NC, Chary KVR and Arora A. (2006) FEBS Journal. 273: 1445–1462.
NMR assignment of peptidyl t-RNA hydrolase from Mycobacterium tuberculosis H37Rv. Bal NC, Agarwal H, Meher AK, Pulavarti SVSRK, Jain A, Kelly G, Frenkiel TA, Pastore A and Arora A. (2006) Journal of Biomol NMR. 36 (5): 53.
Sarcolipin: A potential novel target to counter aging related sarcopenia. Association of Gerontology (INDIA). August 2019. AIIMS, New Delhi India.
2. Non-shivering thermogenesis in the muscle: A cold story. National Conference on Recent Advances in Biological Sciences. April 2019. Sambalpur University, Burla, INDIA.
3. Brown fat vs. the muscle as a target to treat metabolic syndrome. Indian Society of Chemists and Biologists. February 2019. Lucknow, INDIA.
4. Searching a target to treat metabolic syndrome: Brown fat or the muscle? Trends in Biochemical and Biomedical Research: Advances and Challenges. February 2018. Banaras Hindu University (BHU), Varanasi, INDIA.
5. Skeletal muscle as a target for metabolic disorders. 2nd International Conference on Translational Research. October 2016. Bhubaneswar, India.
6. Mammalian thermoregulation: Interplay between the Skeletal Muscle and the Brown Adipose Tissue. June 2016. University of Alaska, Fairbank, AK USA.
7. Skeletal Muscle Compensates for Loss of Brown Adipose Tissue During Cold-Induced Thermogenesis. Advances in Skeletal Muscle Biology in Health and Disease Conference. January 2016. Gainesville, FL, USA.
8. The Role of SR Ca2+-handling in Skeletal Muscle-based Thermogenesis. November 2015. College of Medicine, University of Cincinnati, Cincinnati, OH, USA.
9. The Role of SR Ca2+-handling in Skeletal Muscle-based Thermogenesis. September 2015. School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
10. Understanding the role of skeletal muscle beyond contraction. March 2014. AIIMS, Bhubaneswar, India.
11. Understanding the role of skeletal muscle beyond contraction. March 2014. Regional Centre for Biotechnology, New Delhi, India.
12. Understanding the role of skeletal muscle beyond contraction. March 2014. Institute of Life Sciences, Bhubaneswar, India.
13. Role of two muscle Ca2+-handling proteins in health and disease. June 2013. National Centre For Cell Science (NCCS), Pune, India.
14. Sarcolipin is a missing-link in muscle-based thermogenesis and metabolism. June 2012. The Dorothy M. Davis Heart & Lung Research Institute. The Ohio State University, Columbus, USA.
15. Sarcolipin is a Novel Regulator of Metabolism and Obesity. The Obesity Society. 27th Annual Scientific Meeting. October 2009. Washington, DC, USA.
Role of mitochondrial dynamics in muscle-based nonshivering thermogenesis. Bal NC, Singh S, Maurya SK and Periasamy M. Keystone Symposia on Mitochondrial Dynamics (D2). April 2016. Steamboat Springs, Colorado USA.
2. Understanding the role of sarcolipin in physiology and metabolism. Bal NC and Periasamy M. Advances in Skeletal Muscle Biology in Health and Disease. March 2014. Gainsville, Florida.
3. Two intrinsically disordered motifs fold differently upon Ca2+-binding. Bal NC, Jena N, Kumar A, Sharon A and Periasamy M. 27th Annual Symposium of The Protein Society, 2013. Boston.
4. Sarcolipin is a novel regulator of muscle based thermogenesis and metabolism in mammals. Bal NC, Maurya SK, Saporiwala DH, Sahoo SK, Shaikh SA, Pant M, Rowland LA, and Periasamy M. Experimental Biology, 2013. Boston USA.
5. Skeletal calsequestrin-calcium interaction: Role of acidic C-terminus. Bal NC, Kumar A, Chakravarty H, Balaraju T, Bal C, Jena N, Sharon A and Periasamy M. 57th Annual Meeting of The Biophysical Society, 2013. Philadelphia. USA.
6. The structural basis for the functional differences in CASQ1 and 2 isoforms. Bal NC, Balaraju T, Jena N, Bal C, Sharon A, and Periasamy M. Spring 2012 National Meeting & Exposition, The American Chemical Society, San Diego, California, USA
7. CPVT related mutations alter ionic selectivity and cation-induced molecular folding of the cardiac calsequestrin. Bal NC, Jena N, Sharon A, and Periasamy M. 7th International Biometals Symposium, 2010. Tucson, Arizona, USA
1. Singh S, and Bal NC. Chapter Title: Membrane biophysics. In the book titled Introduction to Biomolecular Structure and Biophysics: Basics of Biophysics. ISBN No. 978-981-10-4967-5. Publisher: Springer Nature Singapore Pte Ltd.
2. Pani S, and Bal NC. Chapter Title: Muscle and aging. In the book titled Models, Molecules and Mechanisms in Biogerontology. Publisher: Springer.