NanoPD

INternational Research Groups

Team Members

NANO DRUG GROUP


Prof. Jen-Shiung JanNational Cheng Kung University

Jen-Shiung Jan (Coordinator)

Prof. Jan focuses on the synthesis and self-assembly of amphiphilic polypeptides and glycopeptides. These self-assembled structures can have potential applications in biomedical field such as drug delivery and encapsulation. They possess essential structures and functions of proteins that can mimic the biological activities and supramolecular structures of natural proteins. He is also interested in the biomimetic or bio-inspired synthesis of inorganic nanomaterials.

STEM CELL GROUP



Prof. Jens Christian SchwambornUniversité du Luxembourg

Jens Christian Schwamborn

Prof. Schwamborn focuses to understand, model and treat Parkinson's disease (PD). Particularly, he is interested in elucidating how developmental processes contribute to the susceptibility to suffer from PD. He uses human stem cells to generate advanced in vitro disease models, including three-dimensional brain organoids (so called “mini-brains”), which shall help us to understand the cellular and molecular processes underlying disease onset and progression. By further developing these models, he will at least partially be able to replace animal experiments and to take an additional step in the direction of personalised medicine. Concerning the molecular processes we are particularly interested in linking the molecular function of PD-associated proteins with cell cycle progression, protein aggregation and mitochondrial / lysosomal function. Additionally to PD, we are also working on Battens disease / Neuronal Ceroid-Lipofuscinosis (NCL), which is a childhood neurodegenerative disease. Multiple projects are funded by the FNR.



Prof. Peter ErtlVienna University of Technology

Peter Ertl

Prof. Ertl has been developing miniaturized analysis systems for a number of years, including lab-on-a-chip systems containing integrated electro- analytical (AMP, ECIS), magnetic (GMR) and optical (OPD) detection methods to continuously monitor blood glucose concentrations, viral contaminations, stem cell fitness, cancer interactions with tissue and immune cells, as well as nanoparticle uptake rates by various tissue types. Another focus of my research group for some years has been the combination of liquid handling systems, electronic components and sensory systems to develop next generation diagnostic devices for biomedical applications. Our latest cell chip system, for instance, consists of computer controlled and pneumatically-activated pumps and valves, degassers and a biochip containing embedded sensor arrays as well as electronic read out. This diagnostic platform can perform a variety of tasks including sample loading, rinsing and washing steps, reagent addition at specific concentrations and gradients, as well as multilevel cell analysis.

Dr. Silvia BologninUniversité du Luxembourg


Silvia Bolognin

Dr. Bolognin has long standing experience in the field of neurodegeneration and tissue engineering. In particular, in her career she has been working on Alzheimer's and Parkinson's disease.

BIOSENSOR GROUP

Prof. Hung-Yin LinNational University of Kaohsiung
http://cme.nuk.edu.tw/files/15-1031-17376,c1987-1.php?Lang=en

Hung-Yin Lin

Prof. Lin focuses to use molecularly imprinted polymers (MIPs) as recognition elements in sensing applications, or for the controlled delivery of small molecule drugs. He uses MIPs in the binding and immobilization of active enzymes. Recently, he synthesizes magnetic/optical MIPs by using phase inversion of poly(ethylene-co-vinyl alcohol) or chitosan. He demonstrates that magnetic molecularly imprinted nanoparticles have the advantages of high surface area, suspension, easy removal from reaction and rapid reload of bioactive molecules (e.g. Cas9).

Prof. Danny O'HareImperial College London
http://www.imperial.ac.uk/people/d.ohare


Danny O'Hare

Prof. O'Hare focuses to develop electrochemical sensors and biosensors for biomedical applications; lab-on-a-chip; signal processing; biofuel cells. Target analytes of their developed sensors include: nitric oxide, dissolved oxygen, serotonin, dopamine, pH, tissue perfusion.


Prof. Shyh-Chyang Luo National Taiwan University

Shyh-Chyang Luo

Prof. Luo's research interest is the behaviors of organic and polymeric materials in aqueous environment. Research targets include conductive organic materials, conducting polymers, and stimuli-responsive materials. We start from the design of building blocks, synthesis, characterization to device assembly. In addition to investigating the nature of between the structures and properties of materials, we focus on how molecules and materials response to the environmental change in aqueous solutions. These materials are used for bioanalysis, bioelectronics and other bioengineering applications.

BIO-ROBOTIC GROUP

Prof. Bradley J. NelsonETH Zurich

Bradley J. Nelson

Prof. Nelson has over thirty years of experience in the field of robotics and has received a number of awards for his work in robotics, nanotechnology, and biomedicine. His research focuses on microrobotics and nanorobotics. Fundamentally, he is interested in how to make tiny intelligent machines that are millimeters to nanometers in size.


Dr. Daniel AhmedETH Zurich


Dainel Ahmed

Dr. Ahmed utilizes acoustics to pursue interdisciplinary research with a strong link to fundamentals in micro/nanorobotics and micro/nanosystems for applications in biomedical engineering, diagnostics, and medicine.


BBB MODEL GROUP

Prof. Maria A. DeliVienna University of Technology

Maria A. Deli

Prof. Deli is a research professor and group leader at the Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences. Mária does research in Toxicology, Pharmacy and Cell Biology fields with special focus on biological barriers. Her team investigates new methods to increase drug delivery across the gut, nasal, respiratory and blood-brain barriers by targeted nanoparticles and also with modulation of the intercellular junctions. Another major research field of the group is barrier dysfunction in diseases, and barrier protection as a therapeutical target. The

Prof. András Dér Hungarian Academy of Sciences

András Dér

Prof. Dér is the leader of the lab of Biomolecular Electronics in the Institute of Biophysics, Hungarian Academy of Sciences. His expertise covers electric and optical phenomena in biological objects on various hierarchical levels of organization, as well as protein dynamics. Recently, he is dealing with the development of lab-on-a-chip measuring platforms for the investigation of the active and passive electric properties of living cells and endothelial tissues.


MICROFLUIDIC GROUP


Prof. Yechezkel (Chezy) Barenholz The Hebrew University-Hadassah Medical School
https://medicine.ekmd.huji.ac.il/en/publications/researchersPages/pages/chezyb.aspx

Yechezkel (Chezy) Barenholz

The Barenholz's Lab focuses on research and application of liposomes based drugs from basic aspects of design of the drug carriers through animal studies and clinical trials, on the way to, FDA-approved drugs. The lab is involved in broad spectrum of projects divided in two main categories. One, Local delivery based on various kinds of large multi-lamellar liposomal vesicles to treat osteoarthritis and large multivesicular vesicles having high trapped volume for local delivery of low and high molecular weight active pharmaceutical ingredients. The second category is based on the use of nano-liposomes for systemic treatments. They also developed novel injectable nano-drug delivery systems, based on pegylated long circulating nano-sterically stabilized liposomes.

Dr. Danny BavliThe Hebrew University-Hadassah Medical School


Danny Bavli

Dr. Bavli is the expert in assay development utilizing microfluidic techniques applied to biological systems. These systems include ‘organ-on chip’ models for cosmetic and pharmaceutical compounds safety evaluation, bioreactor design, nanoparticle synthesis and droplet-based single cell RNA/ChIP sequencing using polymer-based DNA barcoding synthesis and next-generation sequencing.

Dr. Keren TurjemanThe Hebrew University-Hadassah Medical School


Keren Turjeman

Dr. Turjeman is the expert of the liposome-based drug carriers. She focuses on the liposomal nano-drugs based on amphipathic weak acid steroid prodrugs for treatment of inflammatory diseases. Currently, She also develops a anti‐inflammatory agents which is the steroidal nanodrugs based on pegylated nanoliposomes remote loaded with amphipathic weak acids steroid prodrugs.

BIOPHYSICAL GROUP

Dr. David F. SargentETH Zurich
https://www.researchgate.net/profile/David_Sargent

David F. Sargent

Prof. Sargent is developing a system aimed at the selection and manipulation of objects in the micrometer to millimeter range in liquids. As a particular application he's looking into the use of microrobots for the automatic mounting of protein crystals, with the aim of making this process faster and more robust. Progress in this field will contribute to high-throughput structure determination of biological macromolecules by x-ray crystallography, with corresponding benefits to both basic science and medicine.