PN-III-P1-1.1-TE-2016-0919
Nanoparticulate Systems for the Identification of Oncogenes and Delivery of Tumor Inhibitors:
New Strategies for Individualized Treatment of B-lineage Leukemias
The ongoing efforts made in the medical and pharmacological research for the development of new effective anti-cancer drug delivery agents represent enough evidence regarding the importance of this field of research and its strong growing potential.
Lately, nanotechnology demonstrated to be a promising area for the development of such novel materials and this is due to the unique characteristics of nano-objects. With a strong interdisciplinary character (oncomedicine and nanotechnology), the proposed project aims to extend the very recent results obtained by the project leader and his team on the design of innovative nanosystems for the treatment of leukemias.
This project is focused on the development of nanomedicine based nanoparticulate systems that possess multi-functionalities: are capable of identifying specific oncogenes and altogether are able to serve as efficient vehicles for the delivery of tumor inhibitors against B-lineage leukemias.
Specifically, we aim to bring an alternative, nanotechnology-based approach for the targeted delivery of tyrosine kinase inhibitor drugs that are currently used in B-cell acute lymphoblastic leukemia (ALL) treatment and to evaluate the efficacy of functional gold nanoparticles as diagnostic agents by tracking specific oncogenes through the follow-up of the optical response of the particles, in vitro.
Lately, nanotechnology demonstrated to be a promising area for the development of such novel materials and this is due to the unique characteristics of nano-objects. With a strong interdisciplinary character (oncomedicine and nanotechnology), the proposed project aims to extend the very recent results obtained by the project leader and his team on the design of innovative nanosystems for the treatment of leukemias.
This project is focused on the development of nanomedicine based nanoparticulate systems that possess multi-functionalities: are capable of identifying specific oncogenes and altogether are able to serve as efficient vehicles for the delivery of tumor inhibitors against B-lineage leukemias.
Specifically, we aim to bring an alternative, nanotechnology-based approach for the targeted delivery of tyrosine kinase inhibitor drugs that are currently used in B-cell acute lymphoblastic leukemia (ALL) treatment and to evaluate the efficacy of functional gold nanoparticles as diagnostic agents by tracking specific oncogenes through the follow-up of the optical response of the particles, in vitro.
Project Code: PN-III-P1-1.1-TE-2016-0919
Project Nr: 100 - 02/05/2018
Funding Agency: Romanian National Authority for Scientific Research, UEFISCDI
Budget: 450.000 lei
Institution: Babes-Bolyai University, Institute for Interdisciplinary Research in Nano-Bio-Sciences (ICIBNS), Nanobiophotonics and Laser Microspectroscopy Center
Project implementation period: Jan 2020 - Dec 2021
-TEAM-
-TEAM-
Project Leader: CSI Dr. Sanda Boca-Farcau
Team Member: ACS Dr. Andra-Sorina Tatar (PostDoc)
Team Member: CSIII M.D. Ciprian Tomuleasa
Team Member: ACS Dr. Maria-Ancuta Jurj (PostDoc)
Team Member: ACS Iuliana-Madalina Handrea-Dragan (Doc)
Objectives
Objectives
Results
Results