The research activities in Stage I (2021) of the project were carried out according to the plan of implementation, leading to the achievement of all the objectives.

• We have created the official web page of the project

• We have synthesized five classes of colloidal dispersions of plasmonic nanoparticles (PNPs) with well-defined optical properties 

• We have fabricated stable colloidal suspensions based on Raman encoded plasmonic nanoparticles (Raman-PNPs)

• We have prepared stable colloidal suspensions based on aptamer-functionalized, Raman encoded plasmonic nanoparticles (apta-Raman-PNPs) - part 1

• The colloidal suspensions (PNPs, Raman-PNPs and apta-Raman-PNPs) were optically and morphologically characterized

• We have evaluated and optimized the colorimetric/SERS/thermoplasmonic properties of Raman-PNPs in saline solutions

The research activities in Stage II (2022) of the project were carried out according to the plan of implementation, leading to the achievement of all the objectives.

• The official web page of the project was updated

• We have prepared stable colloidal suspensions based on aptamer-functionalized, Raman encoded plasmonic nanoparticles (apta-Raman-PNPs) - part 2

• The colloidal suspensions of apta-Raman-PNPs) were optically characterized -part 2

• We have optimized the analytical parameters for colorimetric/SERS/thermoplasmonic detection of CRP via target-triggered aggregation of PNPs

• We evaluated the sensibility of the colorimetric/SERS/thermoplasmonic assay for CRP detection via target-triggered aggregation of PNPs - part 1

• We evaluated the selectivity of the colorimetric/SERS/thermoplasmonic assay for CRP detection via target-triggered aggregation of PNPs - part 1

The research activities in Stage III (2023) of the project were carried out according to the plan of implementation, leading to the achievement of all the objectives.

• The official web page of the project was updated

• We have optimized the analytical parameters for colorimetric/SERS/thermoplasmonic detection of CRP via target-triggered etching of PNPs

• We evaluated the sensibility of the colorimetric/SERS/thermoplasmonic assay for CRP detection via target-triggered aggregation of PNPs - part 2

• We evaluated the selectivity of the colorimetric/SERS/thermoplasmonic assay for CRP detection via target-triggered aggregation of PNPs - part 2

• We evaluated the sensibility of the colorimetric/SERS/thermoplasmonic assay for CRP detection via target-triggered etching of PNPs

• We evaluated the selectivity of the colorimetric/SERS/thermoplasmonic assay for CRP detection via target-triggered etching of PNPs