HMB

Adolescent HMB

Keypoints

  1. anovulatory cycles mostly

  2. Mild + Hb normal = reassurance + non-hormonal treatments + observation

  3. R/O Pregnacy dx, Bleeding dx

  4. Hormonal therapy aims to stabilise the endometrium

Definitions

  • Normal menstrual blood loss:

    • pads/tampon changes at ≥3 hour intervals

    • seldom overnight

    • < 21 pads(or tampoons) per cycle

  • Excessive menstrual flow:

    • >7 days duration or >80 mL

    • necessitating changing a super pad/tampon more than every 2 hours

    • causing symptomatic anaemia

    • causing lifestyle disturbance

  • Menstrual cycles

    • often irregular and anovulatory in the first few years after menarche.

    • The time to establish regular ovulatory cycles increases with increasing age of menarche

  • Anovulatory uterine bleeding

    • Excessive noncyclic uterine bleeding related to immaturity of the hypothalamic-pituitary-ovarian axis (in the absence of structural uterine lesions or systemic disease)

Causes

  • Pregnancy: miscarriage, ectopic pregnancy, gestational trophoblastic disease

  • Endocrine: anovulatory, thyroid dysfunction, polycystic ovarian syndrome (PCOS)

  • Haematological: von Willebrand Disease, platelet function disorder, thrombocytopenia, other bleeding disorder

  • Medication: hormonal contraception, anticoagulants

  • Other: trauma, infection, malignancy, structural causes (uncommon in adolescence), gastrointestinal bleeding

Step 1. Rapid assessment

  1. Haemodynamic stability ie shock index

  2. Hb

Step 2. History

  • Menstrual history

    • menarche

    • last menstrual period

    • frequency (cycle length) eg every 30 days

    • duration

    • flow ?

    • pain

    • flooding

    • large clots (>2cm in diameter)

    • frequency of pad/tampon changes)

  • Impact on daily life: missing school, sports, social activities

  • Sexual history and contraception

  • Symptoms of

    • Anaemia: dizziness, shortness of breath, fatigue

    • Bleeding disorders: epistaxis, bleeding gums, easy bruising

  • Past medical history including: coagulopathy, platelet function disorders, recurrent haemorrhagic cysts, chronic medical conditions

  • Adolescent assessment (HEADSS screen)


Step 3. Examination

  • Vital signs: hypotension, tachycardia

  • Skin: pallor, petechiae, bruising

  • Abdominal examination: tenderness or pelvic mass

  • Secondary signs of PCOS: acne, excess facial or body hair, weight gain

Vaginal examination is rarely indicated in an adolescent. It should be discussed with a senior clinician, and if needed should only be performed once

Step 4. Severity

  • Mild: Flow:slight q4wkly + Haemodynamic:stable + Hb:normal

  • Mod: Flow:moderate q1-3wkly + Haemodyn: ? + Hb: >100

  • Severe: Flow:heavy OR Haemody: unstable OR Hb:<100

Step 5. Investigations

  • FBE

  • Blood group and antibody screen for severe bleeding

  • Ferritin

  • Coagulation screen

  • TSH

  • Urine or blood ßhCG (with consent)

  • Consider pelvic ultrasound if bleeding accompanied by pain or palpable mass

  • If a bleeding disorder is suspected, consider Platelet function assay (PFA) 100 and von Willebrand screen. These tests should not be done during acute bleeding or with recent NSAID use

Step 6. Management options

  • Mild & no desire for contraception

    1. Reassurance

    2. Observation

    3. NSAIDS & TXA during menses to be considered

  • Moderate

    1. TXA during menses

    2. Hormonal Rx

      • COCP if no contraindications (uncontrolled HTN, CVD, migraine with focal neuro signs, thrombosis risk)

      • POP

  • Severe

    1. Resuscitation

    2. TXA

    3. High dose NET

    4. Iron infusion as required or PRBC transfusion if still unstable despite fluid resus

    5. Specialist gyn review, consider admission

Medication details : https://www.rch.org.au/clinicalguide/guideline_index/Adolescent_Gynaecology_Menorrhagia/