Research

Development and characterization of conventional and novel drug-in-adhesive transdermal delivery systems

Solution and suspension systems, ranging from daily delivery to week-long delivery profiles prepared

Effect of change in adhesives, additives and methods evaluated

Novel transdermal delivery systems for contraception, HIV prophylaxis, ADHD and other mental health disorders successfully developed

Equipments: Casting knives and automated film casting machine; peel, shear and tack testers

Fabrication of drug-loaded dissolving microneedles using various polymers

Non-dissolving microneedles fabricated for rapid and sustained delivery of actives into and across skin

Microneedle and microchannel characterization including histology studies, confocal laser microscopy, dye-binding studies, evaluation of mechanical properties of needles formed, scanning electron microscopy, etc

Pore-closure studies performed in vivo

Enhanced percutaneous delivery of charged and uncharged actives using iontophoresis

Development of conductive formulations to facilitate iontophoresis-mediated delivery

Several peer-reviewed studies published and one of the few research labs having the capability to employ this effective enhancement technique

Ability to enhance percutaneous delivery of hydrophillic active, macromelcules and proteins using various physical enhancement techniques, alone and in combination with formulation strategies

Iontophoresis-mediated delivery as proof of concept and use of microcurrent generating devices

Ablative and non-ablative laser pre-treatment of skin

Microdermabrasion, microneedle devices, radiofrequency, and other cosmetic techniques repurposed for delivery of actives

Sonophoresis, magnetophoresis