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Day 1
25 September 2026
25 September 2026
1.30 p.m.–2.00 p.m.
Registration
Registration
2.00 p.m.–2.15 p.m.
Opening Remarks
Opening Remarks
Gianni Sorarù, Maria Pennuto, Manuela Basso, Matteo Zanovello
2.15 p.m.–3.00 p.m.
Keynote Lecture
Keynote Lecture
Pathophysiology of muscle weakness during disease
Pathophysiology of muscle weakness during disease
Marco Sandri - University of Padova
Session 1 — Decoding Muscle Involvement in MNDs: Pathology, Models, and Omics
Session 1 — Decoding Muscle Involvement in MNDs: Pathology, Models, and Omics
Chairs: Corrado Angelini - Manuela Basso
3.00 p.m.–3.15 p.m.
Muscle biopsy in neurogenic atrophy
Muscle biopsy in neurogenic atrophy
Elena Pegoraro - University of Padova
3.15 p.m.–3.30 p.m.
Beyond the Motor Neuron: Skeletal Muscle in the Pathogenesis of Neuromuscular Diseases
Beyond the Motor Neuron: Skeletal Muscle in the Pathogenesis of Neuromuscular Diseases
Helen Miranda - Case Western Reserve University
3.30 p.m.–3.45 p.m.
Unlocking organoids to unravel human neuromuscular function and disease
Unlocking organoids to unravel human neuromuscular function and disease
Anna Urciuolo - University of Padova
3.45 p.m.–4.00 p.m.
The role of energy consumption of resting skeletal muscle on hypermetabolism in ALS patients
The role of energy consumption of resting skeletal muscle on hypermetabolism in ALS patients
Bert Blaauw - University of Padova
4.00 p.m.–4.15 p.m.
The Muscle–Nerve Dialogue: miR-206 as a Regulator of Sympathetic Innervation
The Muscle–Nerve Dialogue: miR-206 as a Regulator of Sympathetic Innervation
Tania Zaglia - University of Padova
4.15 p.m.–4.45 p.m.
Coffee Break & Poster Viewing
Coffee Break & Poster Viewing
4.45 p.m.–5.30 p.m.
Short talks selected from abstracts
Short talks selected from abstracts
Session 2 — Muscle and NMJ Pathophysiology in ALS
Session 2 — Muscle and NMJ Pathophysiology in ALS
Chairs: Antonio Musarò - Maria Pennuto
5.30 p.m.–5.45 p.m.
The RNA-binding protein HuD at the crossroads of oxidative stress and NMJ defects in sporadic ALS
The RNA-binding protein HuD at the crossroads of oxidative stress and NMJ defects in sporadic ALS
Alessandro Rosa - University "La Sapienza" Rome
5.45 p.m.–6.00 p.m.
Motor neuron vulnerability and plasticity: insights from C9orf72 DPR knock-in mouse models
Motor neuron vulnerability and plasticity: insights from C9orf72 DPR knock-in mouse models
Carmelo Milioto - University of Milan
6.00 p.m.–6.15 p.m.
Local translation defects in the ALS lower motor neuron circuitry
Local translation defects in the ALS lower motor neuron circuitry
Diana Piol - University of Padova
6.15 p.m.–6.30 p.m.
Molecular Insights into the Muscle–NMJ Axis in ALS
Molecular Insights into the Muscle–NMJ Axis in ALS
Udai Pandey - University of Pittsburgh
6.30 p.m.–6.45 p.m.
From the Peripheral Nerve to Muscle: a PNS Perspective on ALS
From the Peripheral Nerve to Muscle: a PNS Perspective on ALS
Nilo Riva - IRCSS Carlo Besta
6.45 p.m.–7.00 p.m.
Day 1 Wrap-up
Day 1 Wrap-up
Gianni Sorarù, Maria Pennuto, Manuela Basso, Matteo Zanovello
Day 2
26 September 2026
26 September 2026
9.00 a.m.–9.45 a.m.
Keynote Lecture
Keynote Lecture
Muscle as a Window and Target in ALS: Insights from MRI and TDP-43 Pathology
Muscle as a Window and Target in ALS: Insights from MRI and TDP-43 Pathology
Pietro Fratta - UCL
Session 3 — Muscle Biomarkers in ALS
Session 3 — Muscle Biomarkers in ALS
Chairs: Federico Verde - Matteo Zanovello
9.45 a.m.–10.00 a.m.
Which part might a muscle biomarker play among neurochemical ALS biomarkers?
Which part might a muscle biomarker play among neurochemical ALS biomarkers?
Albert Ludolph - University of Ulm
10.00 a.m.–10.15 a.m.
Teaching an old dog new tricks: repurposing cardiac Troponin T as a biomarker for ALS
Teaching an old dog new tricks: repurposing cardiac Troponin T as a biomarker for ALS
Patrick Weydt - University of Bonn
10.15 a.m.–10.30 a.m.
Biomarkers of Motoneuronal dysfunction in health and disease
Biomarkers of Motoneuronal dysfunction in health and disease
Giuseppe De Vito - University of Padova
10.30 a.m.–10.45 a.m.
Lessons from sporadic inclusion body myositis (sIBM)
Lessons from sporadic inclusion body myositis (sIBM)
Gaetano Vattemi - University of Verona
10.45 a.m.–11.00 a.m.
Toward reliable and responsible ALS progression prediction: development and external validation of clinical models
Toward reliable and responsible ALS progression prediction: development and external validation of clinical models
Barbara Di Camillo - University of Padova
11.00 a.m.–11.30 a.m.
Coffee Break & Poster Viewing
Coffee Break & Poster Viewing
Session 4 — Therapeutic Strategies Targeting the Skeletal Muscle
Session 4 — Therapeutic Strategies Targeting the Skeletal Muscle
Chairs: Adriano Chiò - Gianni Sorarù
11.30 a.m.–11.45 a.m.
Leveraging three-dimensional patient-specific in vitro models to test therapeutic strategies in ALS
Leveraging three-dimensional patient-specific in vitro models to test therapeutic strategies in ALS
Delia Gagliardi - University of Milan
11.45 a.m.–12.00 p.m.
Targeting neuromuscular junction regeneration as a therapeutic strategy in ALS
Targeting neuromuscular junction regeneration as a therapeutic strategy in ALS
Michela Rigoni - University of Padova
12.00 p.m.–12.15 p.m.
miRNA-Mediated Crosstalk Between Skeletal Muscle and Motor Neurons in ALS: Implications for NMJ Formation and Regeneration
miRNA-Mediated Crosstalk Between Skeletal Muscle and Motor Neurons in ALS: Implications for NMJ Formation and Regeneration
Stefano Cagnin - University of Padova
12.15 p.m.–12.30 p.m.
Safety and efficacy considerations in muscle-directed AAV gene therapy
Safety and efficacy considerations in muscle-directed AAV gene therapy
Giuseppe Ronzitti - Genethon
12.30 p.m.–12.45 p.m.
Targeted IL-10 Delivery to Remodel Immune-Driven Skeletal Muscle Pathology in ALS
Targeted IL-10 Delivery to Remodel Immune-Driven Skeletal Muscle Pathology in ALS
Giovanni Nardo - IRCSS Mario Negri
12.45 p.m.–1.00 p.m.
Closing Remarks & Future Directions
Closing Remarks & Future Directions
Gianni Sorarù, Maria Pennuto, Manuela Basso, Matteo Zanovello
1.00 p.m.–2.30 p.m.
Light Lunch & Poster Viewing
Light Lunch & Poster Viewing
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