Current Research
Generation of a Comprehensive Lineage Tree Utilizing Diverse Mutation Profiles of mitochondrial mutations and Homing mutations and RNA Information
*Work in Progress
multiHIVE: Hierarchical Deep Generative Modeling of Single-cell Multiomics
Anirudh Nanduri, Musale Krushna Pavan, Kushagra Pandey, Hamim Zafar
*Work in Progress
Publications
Ajita Shree*, Musale Krushna Pavan* & Hamim Zafar*equally contributed
Nature Communications 14 (1), 7781
Mirazul Islam, Yilin Yang, Alan Simmons, Vishal Shah, Musale Krushna Pavan, Yanwen Xu, Naila Tasneem, Zhengyi Chen, Linh Trinh, Paola Molina, Marisol Ramirez, Iannish Sadien, Jinzhuang Dou, Ken Chen, Mark Magnuson, Jeffrey Rathmell, Ian Macara, Douglas Winton, Qi Liu, Hamim Zafar, Reza Kalhor, George Church, Martha Shrubsole, Robert Coffey
*under Submission
Temporal Multiomics Atlas of Pancreatic Islets in Euglycemic and Hyperglycemic States
Simran Singh*, Musale Krushna Pavan*, Luzi F. Barella* , Jayesh Telang , Ajita Shree , Hamim Zafar, Jurgen Wess, Sai Prasad Pydi
*equally contributed*manscript under preperation
Future Plans
Computational methods for reconstructing cell lineage,invariant and variable lineage maps, and joint celltype embeddings by integrating single-cell multiomics datasets
It is critical to reconstruct a complete map that integrates cell lineage with cell-fate decisions in order to fully understand the function of cellular dynamics in normal and pathological development. The aggregate pattern of cell divisions that gives rise to a completely developed tissue or a complete organism from a founding cell is referred to as ’cell lineage’