Current Research
Current Research
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Generation of a Comprehensive Lineage Tree Utilizing Mutation Profile and RNA Information
Generation of a Comprehensive Lineage Tree Utilizing Mutation Profile and RNA Information
*Work in Progress
Publications
Publications
Anirudh Nanduri^, Musale Krushna Pavan^, Kushagra Pandey, Hamim Zafar
*Under Submission
^equally contributed
Simran Singh*, Musale Krushna Pavan*, Luzi F. Barella* , Jayesh Telang , Ajita Shree , Hamim Zafar, Jurgen Wess, Sai Prasad Pydi
*equally contributed
Faster Amylin Aggregation on Fibrillar Collagen I Hastens Diabetic Progression through β-Cell Death and Loss of Function
Faster Amylin Aggregation on Fibrillar Collagen I Hastens Diabetic Progression through β-Cell Death and Loss of Function
Md Asrafuddoza Hazari, Gautam Kannan, Subrata Dasgupta, Musale Krushna Pavan, Akash Kumar Jha, Farhin Sultana, Soumya Ranjan Pujahari, Simran Singh, Sarbajeet Dutta, Sai Prasad Pydi, Sankhadeep Dutta, Hamim Zafar, Prasenjit Bhaumik, Ashutosh Kumar, and Shamik Sen
Journal of the American Chemical Society (JACS)
Mirazul Islam, Yilin Yang, Alan Simmons, Vishal Shah, Musale Krushna Pavan, Yanwen Xu, Naila Tasneem, Zhengyi Chen, Linh Trinh, Paola Molina, Marisol Ramirez, Iannish Sadien, Jinzhuang Dou, Ken Chen, Mark Magnuson, Jeffrey Rathmell, Ian Macara, Douglas Winton, Qi Liu, Hamim Zafar, Reza Kalhor, George Church, Martha Shrubsole, Robert Coffey
Nature volume 634, pages1187–1195 (2024)
Ajita Shree*, Musale Krushna Pavan* & Hamim Zafar*equally contributed
Nature Communications 14 (1), 7781
Future Plans
Future Plans
Computational methods for reconstructing cell lineage,invariant and variable lineage maps, and joint celltype embeddings by integrating single-cell multiomics datasets
Computational methods for reconstructing cell lineage,invariant and variable lineage maps, and joint celltype embeddings by integrating single-cell multiomics datasets
It is critical to reconstruct a complete map that integrates cell lineage with cell-fate decisions in order to fully understand the function of cellular dynamics in normal and pathological development. The aggregate pattern of cell divisions that gives rise to a completely developed tissue or a complete organism from a founding cell is referred to as ’cell lineage’
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