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Enzymatic synthesis of hybrid biopolymers
Enzymatic synthesis of hybrid biopolymers
We are exploiting the potential of natural enzymes to design chimeric enzymes that efficiently synthesize novel linkages between biopolymers like peptides, oligonucleotides etc.
Assembly of nanomachines for novel bioproduct synthesis
Assembly of nanomachines for novel bioproduct synthesis
DNA-mediated assembly of unnatural enzyme complexes can bring about novel reactions. We are interested in achieving reactions difficult to accomplish with conventional organic synthesis.
Secondary-structure based strategy for protein humanization
Secondary-structure based strategy for protein humanization
Many protein biotherapeutics of non-human sources are rejected because of immunogenicity concerns. Drawing inspiration from the "antibody humanization" approach, we are developing a pipeline that will allow the deimmunization of any protein of choice.
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