PUBLICATIONS

Research Articles at Case Western

1. Chen X, Wang YJ, Mu TW (2025) Missense variants in GABAA receptor beta2 subunit disrupt receptor biogenesis and cause loss of function. bioRxiv, doi: 10.1101/2025.03.09.642292.

2. Benske TM, Williams MP, Zhang PP, Palumbo AJ, Mu TW (2025) A GluN2B disease-associated variant promotes degradation of NMDA receptors via autophagy. bioRxiv, doi: 10.1101/2025.01.12.632651.

3. Williams MP, Wang YJ, Kang JQ, Perryman JH, Mu TW (2025) GABRA1 frameshift variants impair GABAA receptor proteostasis. bioRxiv, doi: 10.1101/2024.11.28.625971. PMID: 39651292.

4. Srivastava V, Liu Z, Wei W, Zhang Y, Paton JC, Paton AW, Mu T, Zhang B (2025) Cell-based small-molecule screening identifying proteostasis regulators enhancing Factor VIII missense mutant secretion. Biomolecules. 15(4):458. https://doi.org/10.3390/biom15040458.

5. Wang YJ, Seibert H, Ahn LY, Schaffer AE, Mu TW (2024) Pharmacological chaperones restore proteostasis of epilepsy-associated GABAA receptor variants. Pharmacological Research, doi: 10.1016/j.phrs.2024.107356. PMID: 39216838

6. Wang YJ, Di XJ, Zhang PP, Chen X, Williams MP, Han DY, Nashmi R, Henderson BJ, Moss FJ, Mu TW (2024) Hsp47 Promotes Biogenesis of Multi-subunit Neuroreceptors in the Endoplasmic Reticulum. bioRxiv, doi: https://doi.org/10.1101/2022.10.24.513629. eLife, doi: 10.7554/eLife.84798.PMID: 38963323.

7. Wang YJ, Vu GH, Mu TW (2024) Pathogenicity Prediction of GABAA Receptor Missense Variants. bioRxiv, doi: https://doi.org/10.1101/2023.11.14.567135. PMID: 38014242. Israel Journal of Chemistry, doi: 10.1002/ijch.202300161.

8. Zhang PP, Benske TM, Paton JC, Paton AW, Mu  TW, Wang YJ (2023) Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants. Acta Pharmacologica Sinica, doi: 10.1038/s41401-023-01172-w. PMID: 37803141

9. Wang YJ, Di XJ, Mu TW (2022) Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors. Journal of Biological Chemistry, https://doi.org/10.1016/j.jbc.2022.102423. PMID: 36030824

10. Wang M, Cotter E, Wang YJ, Fu X, Whittsette AL, Lynch JW, Wiseman RL, Kelly JW, Keramidas A, Mu TW (2022). Pharmacologic ATF6 Activation Remodels the Proteostasis Network to Rescue Pathogenic GABAA Receptors. Cell & Bioscience. 12, 48. https://doi.org/10.1186/s13578-022-00783-w. PMID: 35477478

11. Whittsette AL, Wang YJ, Mu TW (2022) The Endoplasmic Reticulum Membrane Complex Promotes Proteostasis of GABAA Receptors. iScience, https://doi.org/10.1016/j.isci.2022.104754. PMID: 35938049  

12. Kuanyshbek AB, Wang M, Anderson Å, Tuifua M, Palmer EE, Sachdev RK, Mu TW, Vetter I, Keramidas A (2022). Anti-seizure mechanisms of midazolam and valproate at the β2(L51M) variant of the GABAA receptor. Neuropharmacology. doi: 10.1016/j.neuropharm.2022.109295. PMID: 36257447

13. Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, et al. Mu TW, et al. Topisirovic I, Larsson O, Hatzoglou M (2022) Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR. Cell Reports, 40:111092. https://doi.org/10.1016/j.celrep.2022.111092. PMID: 35858571

14. Di XJ, Wang YJ, Cotter E, Wang M, Whittsette AL, Han DY, Sangwung P, Brown R, Lynch JW, Keramidas A, Mu TW (2021) Proteostasis regulators restore function of epilepsy-associated GABAA receptors, Cell Chem Biol. 28 (1), 46-59. e7 https://doi.org/10.1016/j.chembiol.2020.08.012 PMID: 32888501.

15. Yan-Lin Fu, Bin Zhang, and Ting-Wei Mu (2019) LMAN1 (ERGIC-53) promotes the trafficking of neuroreceptors. Biochemical and Biophysical Research Communications. 511(2):356-362. PMID: 30791981.

16. Yan-Lin Fu, Dong-Yun Han, Ya-Juan Wang, Xiao-Jing Di, Hai-Bo Yu, and Ting-Wei Mu (2018) Remodeling the Endoplasmic Reticulum Proteostasis Network Restores Proteostasis of Pathogenic GABAA Receptors. PLoS ONE, 13(11):e0207948. PMID: 30481215.

17. Dawid Krokowski, Bo-Jhih Guan, Jing Wu, Yuke Zheng, Padmanabhan Pattabiraman, Raul Jobava, Xiao-Jing Di, Martin Snider, Ting-Wei Mu, Eric Pearlman, Anna Blumental-Perry, and Maria Hatzoglou (2017) GADD34 promotes Golgi apparatus integrity and osmoadaptation of human corneal cells. Cell Reports, 21(10):2895-2910. PMCID: PMC5720379.

18. Di, XJ, Wang, YJ, Han, DY, Fu, YL, Duerfeldt, AS, Blagg, BSJ, Mu, TW (2016) Grp94 protein delivers g-aminobutyric acid (GABAA) Receptors to Hrd1 protein-mediated Endoplasmic Reticulum-Associated Degradation. Journal of Biological Chemistry, 291:9526-9539. PMID: 26945068.

19. Han DY, Guan BJ, Wang YJ, Hatzoglou M, Mu TW (2015) L-type calcium channel blockers enhance trafficking and function of epilepsy-associated a1(D219N) subunits of GABAA receptors. ACS Chemical Biology, 10:2135-2148. PMID: 2616828.

20. Han DY, Di XJ, Fu YL, Mu TW (2015) Combining valosin-containing protein (VCP) inhibition and suberanilohydroxamic Acid (SAHA) treatment additively enhances the folding, trafficking, and function of epilepsy-associated γ-aminobutyric acid, type A (GABAA) receptors. Journal of Biological Chemistry, 290:325-337. PMCID: PMC4281735.

21. Wang YJ, Tayo BO, Bandyopadhyay A, Wang H, Feng T, Franceschini N, Tang H, Gao J, COGENT consortium, Williams SM, Elston RC, Cooper RS, Mu TW, Zhu X (2014) The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic-reticulum-associated degradation and loss of function. PLoS Genetics, 10(9):e1004641. PMCID: PMC4169380

22. Di XJ, Han DY, Wang YJ, Chance MR, Mu TW (2013) SAHA enhances proteostasis of epilepsy-associated α1(A322D)β2γ2 GABAA receptors. Chemistry & Biology, 20: 1456-1468. doi: 10.1016/j.chembiol.2013.09.020. PubMed PMID: 24211135; PubMed Central PMCID: PMC3872227.

23. Wang YJ, Han DY, Tabib T, Yates JR, Mu TW (2013) Identification of GABAC receptor protein homeostasis network components from three tandem mass spectrometry proteomics approaches. Journal of Proteome Research, 12: 5570-5586. doi: 10.1021/pr400535z. PubMed PMID: 24079818; PubMed Central PMCID: PMC3864119.

Research Articles before Case Western

24. Ong DS, Wang YJ, Tan YL, Yates JR,* Mu TW,* Kelly JW* (2013) FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher’s disease fibroblasts. Chemistry & Biology, 20: 403-415. doi: 10.1016/j.chembiol.2012.11.014. PubMed PMID: 23434032; PubMed Central PMCID: PMC3624024. * corresponding author

25. Ong DS, Mu TW, Palmer AE, Kelly JW (2010) Endoplasmic reticulum Ca2+ increases enhance glucocerebrosidase folding, trafficking and function. Nature Chemical Biology, 6:424-432.

26. Mu TW, Ong DS, Wang YJ, Balch WE, Yates JR, Segatori L, Kelly JW (2008) Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell, 134:769-791. Highlighted in Science.

27. Mu TW, Fowler DM, Kelly JW (2008) Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biology, 6: e26. Highlighted in ACS Chemical Biology.

28. Mu TW, Lester HA, Dougherty DA (2003) Different binding orientations for the same agonist at homologous receptors: A lock and key or a simple wedge? J Am Chem Soc, 125: 6850-6851.

29. Feng Y, Liu L, Mu TW, Guo QX (2002) Influence of a hydrophobic enviromment on the structure of arginine-carboxylate salt bridge. Chin J Chem 20: 958-962.

30. Mu TW, Liu L, Li XS, Guo QX (2001) A theoretical study on the inclusion complexation of cyclodextrins with radical cations and anions. J Phys Org Chem 14: 559-565.

31. Zhang KC, Mu TW, Liu L, Guo QX (2001) A theoretical study on cucurbit[7]uril and its inclusion complexation. Chin J Chem 19: 558-561.

32. Mu TW, Liu L, Zhang KC, Guo QX (2001) A theoretical study on the stereoisomerism in the complex of cucurbit[8]uril with 2,6-bis(4, 5-dihydro-1H-imidazol-2-yl)naphthalene. Chin Chem Lett 12: 783-786.

33. Zhang KC, Liu L, Mu TW, Guo QX (2001) Ab initio calculations on the inclusion complexation of cyclobis(paraquat-p-phenylene). Chem Phys Lett 333: 195-198.

34. Zhang KC, Liu L, Mu TW, Guo QX (2001) Molecular modeling on the complexation of cyclobis(paraquat-p-phenylene) with tetrathiafulvalenes. J Incl Phenom Macrocycl Chem 40: 189-191.

35. Yang C, Liu L, Mu TW, Guo QX (2001) Improved accuracy and efficiency in the determination of association constants with the spectrophotometric method. J Incl Phenom Macrocycl Chem 39: 97-101.

36. Mu TW, Feng Y, Liu L, Guo QX (2001) On the structure of the arginine-carboxylate salt bridge: A density functional theory study. Chin Chem Lett 12: 219-222.

37. Liu L, Yang C, Mu TW, Guo QX (2001) A statistical examination on the compensation between the enthalpies and entropies obtained from the calorimetric methods. Chin Chem Lett 12: 167-170.

38. Zhang KC, Liu L, Mu TW, Guo QX (2000) A molecular modeling for the complexation of cyclobis(paraquat-p-phenylene) with substituted benzenes and biphenyls. Chin Chem Lett 11: 985-988.

39. Yang C, Liu L, Mu TW, Guo QX (2000) The performance of the Benesi-Hildebrand method in measuring the binding constants of the cyclodextrin complexation. Anal Sci 16: 537-539.

40. Liu L, Li XS, Mu TW, Guo QX, Liu YC (2000) Interplay between molecular recognition and redox properties: A theoretical study of the inclusion complexation of beta-cyclodextrin with phenothiazine and its radical cation. J Incl Phenom Macrocycl Chem 38: 199-206.

41. Li XS, Liu L, Mu TW, Guo QX, Liu YC (2000) A theoretical study on the structure and properties of phenothiazine derivatives and their radical cations. Res Chem Intermed 26: 375-384.

42. Li XS, Liu L, Mu TW, Guo QX (2000) A systematic quantum chemistry study on cyclodextrins. Mon Chem 131: 849-855.

Reviews, Book Chapters

43. Chen X, Wang YJ, Mu TW (2025) Proteostasis regulation of GABAA receptors in neuronal function and disease, Biomedicine & Pharmacotherapy, https://doi.org/10.1016/j.biopha.2025.117992. PMID: 40112516.

44. Chen X, Mu TW, Wang YJ (2023) Application of Proteostasis Regulators in GABAA Receptor Misfolding Diseases. J Biomed Res Environ Sci. 2023 Nov 28; 4(11): 1640-1644. doi: 10.37871/jbres1843, Article ID: JBRES1843, Available at: https://www.jelsciences.com/articles/jbres1843.pdf

45. Benske T, Mu TW, Wang YJ (2022) Protein Quality Control of N-methyl-D-aspartate Receptors. Front. Cell. Neurosci. - Cellular Neurophysiology, DOI: 10.3389/fncel.2022.907560. PMID: 35936491. 

46. Fu X, Wang YJ, Kang JQ, Mu TW (2022) GABAA Receptor Variants in Epilepsy, in Epilepsy, Exon Publications, Doi: https://doi.org/10.36255/exon-publications-epilepsy-gaba-receptor. PMID: 35605087.

47. Wang YJ, Mu TW (2019) Interactome Changes Quantified to Identify the ER Proteostasis Network to Fight Amyloid Diseases. Cell Chem Biol 26:909-910. PMID: 31323219.

48. Fu YL, Wang YJ, Mu TW (2016) Proteostasis maintenance of Cys-loop receptors. Advances in Protein Chemistry and Structural Biology. 103:1-23. PMID: 26920686.

49. Wang YJ, Di XJ, Mu TW (2014) Using pharmacological chaperones to restore proteostasis (Review). Pharmacological Research, 83: 3-9. PMCID: PMC4070435.