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Investigating the dynamicity of Cell-Mitochondria associations
What we do !
What we do !
Mitochondria are bioenergetic, biosynthetic and signaling organelles that are integral in stress sensing to allow for cellular adaptation to the environment. Cellular transformation is supported by different aspects of mitochondria biology which includes biogenesis and turnover, fission and fusion dynamics, cell death susceptibility, oxidative stress regulation, metabolism, and signaling. The goal of our lab is to elucidate the hardwiring of mitochondria with the biochemical networks controlling cell proliferation, differentiation and cell-fate decisions. Using human cell line models of breast cancer and Drosophila melanogaster, coupled with classical and next-gen technologies we try to uncover how mitochondria metabolism, dynamics and biogenesis influences the signal patterns and cell-cell communication to promote redox homeostasis, adaption to stress and xenobiotics.
Core areas of Investigation
Core areas of Investigation
Mitochondria biogenesis and dynamics
Mitochondria biogenesis and dynamics
How unbalanced mitochondrial fusion and fission causes activation of oncogenic pathways leading to cancer cell survival, adaptation to energy stress and how these process in turn, control the biogenesis of the organelle.
Redox signaling
Redox signaling
We focus on the Redox signals originating from mitochondria, their mechanisms and how they are relayed to extramitochondrial targets to influence physiological processes.
Mitochondria associated pathophysiologies
Mitochondria associated pathophysiologies
Our focus is to isolate the driver mutations which are responsible for failure of mitochondrial quality control and clinical manifestations associated with cardiac diseases such as atherosclerosis, ischemia-reperfusion injury, hypertension, cardiac hypertrophy and heart failure
Artificial regulation of redox homeostasis
Artificial regulation of redox homeostasis
Uncontrolled production of reactive oxygen species is associated with several degenerative, metabolic diseases, genome instability and physiologic process of aging. Our aim of future research is to design molecules which selectively target mitochondrial dysfunction and restore the capacity or supplement the activity of cellular antioxidant enzymes.
Recent Updates
Recent Updates
A Fantastic 2024 for the lab. Multiple laurels by mitoSig Lab members. Check details in Lab News!!
Congratulations!! Priyadarshika Pradhan for successfully defending her thesis. Good Luck for the future!!
Congratulations!! Priyadarshika Pradhan, Olivia Majhi and Tanvi Chaudhary for being awarded EMBO Travel Grant for attending EMBO conferences.
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