News!

Submitted Article! July-2025

1.  Hazra*, M.K. and Levy, Y*, Binding mechanism of highly charged disordered proteins: Interplay between conformational and counter-ion entropies (Under Review (As Corresponding Author))

2. Hazra*, M. K., Differential Sequence Charge-clustering and Mixing-ratio Affect Stability and Dynamics of Heterotypic Peptide Condensates 

(Under Review (As Corresponding Author))

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=5371756

DOI:https://doi.org/10.1101/2025.07.25.666616

Publication Alert!

1. Bhagat, S., Hazra*, M.K., Pal*, S., Solute rearrangement in dimethyl sulfoxide-water mixture: An integrative solvent detected NMR and MD approach, J. Mol. Liq., vol. 434,2025, 128010, pp-1-14 (As Corresponding Author)

DOI:https://doi.org/10.1016/j.molliq.2025.128010

2. Agarwala, P., Pal, A., Hazra*, M. K., Sasmal*, D. K., Differential Mg2+ Deposition on DNA Holliday Junctions Dictates the Rate and Stability of Conformational Exchange, Nanoscale, vol. 17 (1),2025, pp-520-532 (As Corresponding Author).

DOI: https://doi.org/10.1039/D4NR02411G

June 2025--We earnestly thank ANRF for Prime Minister Early Career Research Grant. We have an open position for a JRF! Please write to me if you are fascinated to understand minute biological rhythm applying fundamental physics in-silico! 

Project Title: Understanding context-dependent functional importance of sequence-specific chemical modifications in structure-assembly-dynamics of disordered protein-RNA heterotypic network mesh in biomolecular condensates

The selected candidate is supposed to work on the following objectives: 

1. To design all-atom and derived coarse-grained force field for various time-dependent reversible post-translational and post-transcriptional modifications to decode their effect on the structural ensemble of disordered proteins and RNAs respectively at diverse functional contexts. 

2. Our approaches will unravel insights into the tunability of molecular recognition mechanism and selectivity of one molecule over another one through different compositional control of such PTMs/PRMs in proteins and RNA. 

3. Impact of the extent of mixing different PRMs/PTMs on condensate stability and its intrinsic dynamics will be elucidated.

Duration (In Month): 12 (Given progress of the project is satisfactory extendable up to maximum 24 months)

January 2024--We have received Seed fund from IIT Jodhpur to initiate our research!