Molecular Systems Biophysics Lab: Bridging Scales

We are a budding group of theoretical physical chemists, fascinated to understand minute regulations in biological systems in diverse time and length scales. Blending molecular simulations with the formulations of statistical mechanics, we are currently aiming toward developing an understanding of entropy mediated subtle molecular recognition processes, dynamic autoinhibition by IDR conformational ensembles and functional disorder in molecular chaperones. In addition, with our mesoscale structure-based coarse-grained simulation approach, we will look at chromatin organization in cell nucleus at molecular length scales. Apart from finding the answers of fundamental problems at the interface of chemistry and biology, we even develop and employ new computational methods to study problems of our interest.