Vaccine & Cancer Therapy Innovations
| Lai Lab

Publications:

1. Cha, I, Yamada, Y, Kim, D, Kang S, Yang WS, Shih WJ, Ryder A, Lewis M, Chung C, Cho NH, Choi YK, Li J, Lai CJ#, Jung JU. A viral codon usage strategy enhances antigen production and protection in SFTSV mRNA vaccination. NPJ VACCINES. 2025 Nov 24;10(1):248. #(co-corresponding author) 

2. Lee CY, Fu YK, Yeh CC, Kuo LK, Kuo YY, Huo C, Lee SW, Huang YC, Shih LJ, Li CY, Huang SP, Lai CJ#, Chuu CP. Combined Treatment of Cisplatin With Caffeic Acid Phenethyl Ester Demonstrates Additive Growth Inhibition on Non-small Cell Lung Cancer Cells. ANTICANCER RES. 2025 Nov;45(11):4971-4986. #(co-corresponding author) 

3. Wang YP, Wang BJ, Lu HY, Muller CJF, Kuo YY, Huo C, Lai CJ, Huang SH, Joubert E, Chuu CP. Aspalathin-Rich Unfermented Aspalathus linearsis Extract Mitigates Vascular Endothelial Inflammation by Inhibiting the TNF-α/Hexokinase 2/NF-κB Signaling Pathway. J AGR FOOD RES. 2025 Apr 101882

4. Yang WS, Kim D, Kang S, Lai CJ, Cha I, Chang PC, Jung JU. Development of KSHV vaccine platforms and chimeric MHV68-K-K8. 1 glycoprotein for evaluating the in vivo immunogenicity and efficacy of KSHV vaccine candidates. mBio. 2024, Oct: e02913-24. 

5. Kim D, Lai CJ, Cha I, Jung JU. Current Progress of Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) Vaccine Development. Viruses. 2024, 16(1), 128 

6. Lai CJ, Kim D, Kang SM, Li K, Cha I, Sasaki A, Porras J, Xia T, Jung JU. Viral codon optimization on SARS-CoV-2 Spike boosts immunity in the development of COVID-19 mRNA vaccines. J Med Virol. 2023 Jan;95(10): e29183. 

7. Kim D, Lai CJ#, Cha I, Kang S, Yang WS, Choi Y, Jung JU. SFTSV Gn-Head mRNA vaccine confers efficient protection against lethal viral challenge. J Med Virol. 2023 Nov;95(11): e29203. # (co-first author)

8. Kim D, Kim E, Kim S, Chung Y, Lai CJ, Cha I, Cho SD, Choi Y, Dai X, Kim S, Kang S, Kwak MJ, Liu Z, Choi Y, Park SH, Choi YK, Jung JU. Self-assembling Gn head ferritin nanoparticle vaccine provides full protection from lethal challenge of Dabie bandavirus in aged ferrets. mBio. 2023 Sep 15;14(5): e0186823

9. Song J, Jeong BS, Kim SW, Im SB, Kim S, Lai CJ, Cho W, Jung JU, Ahn MJ, Oh BH. Noncovalent antibody catenation on a target surface greatly increases the antigen-binding avidity. Elife. 2023 May 30;12: e81646 

10. Xia T, Wu X, Hong E, Jung K, Lai CJ, Kwak MJ, Seo HD, Kim S, Jiang ZY, Cha I, Jung JU. Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion. PLoS Pathog. 2023 Mar; 19(3): e1011232 

11. Jeong BS, Jeon JY, Lai CJ, Yun HY, Jung JU, Oh BH. Structural basis for the broad and potent cross-reactivity of an N501Ycentric antibody against sarbecoviruses. Front Immunol. 2022 Nov 17; 13:1049867 

12. Ho CH, Chen ML, Huang HL, Lai CJ, Liu CH, Chuu CP, Lin YH. Active Targeting of P-Selectin by Fucoidan Modulates the Molecular Profiling of Metastasis in Docetaxel-Resistant Prostate Cancer. Mar Drugs. 2022 Sep 20 (9), 542. 

13. Choi UY, Lee JJ, Park A, Jung KL, Lee SA, Choi YJ, Lee HR, Lai CJ, Eoh H, Jung JU. Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance. Cell Rep 2022 Aug 16;40(7):111234. 

14. Kim YI, Kim D, Yu KM, Seo HD, Lee SA, Casel MAB, Jang SG, Kim S, Jung W, Lai CJ, Choi YK, Jung JU. Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets. mBio. 2021 Mar 2;12(2)

15. Chen ML, Lai CJ, Lin YN, Huang CM, Lin YH. Multifunctional nanoparticles for targeting the tumor microenvironment to improve synergistic drug combinations and cancer treatment effects. J Mater Chem B. 2020 Dec 7;8(45):10416-10427. 

16. Lai CJ, Lin CY, Liao WY, Hour TC, Wang HD, Chuu CP. CD44 Promotes Migration and Invasion of Docetaxel-Resistant Prostate Cancer Cells Likely via Induction of Hippo-Yap Signaling. Cells. 2019 Mar 30;8(4). 

17. Lai CJ, Cheng HC, Lin CY, Huang SH, Chen TH, Chung CJ, Chang CH, Wang HD, Chuu CP. Activation of liver X receptor suppresses angiogenesis via induction of ApoD. FASEB J. 2017 Dec;31 (12):5568-5576.

18. Kuo YY, Jim WT, Su LC, Chung CJ, Lin CY, Huo C, Tseng JC, Huang SH, Lai CJ, Chen BC, Wang BJ, Chan TM, Lin HP, Chang WS, Chang CR, Chuu CP. Caffeic Acid phenethyl ester is a potential therapeutic agent for oral cancer. Int J Mol Sci. May 2015