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Exploring biocompatability of Mxene nanosheets
In collaboration with Prof. Vinod Verma's Research group at SGPGIMS, Lucknow, we are working to show the biocompatibility of Mxene nanosheets for stem cell growth.
For detailed understanding of our work, please read our recently published research article.
Singh, S. K., Paul, M., Singh, A., Sharma, A., Kumar, M., Gupta, J., ... & Verma, V. (2024). Development of MXene Composite Nanofiber-Based 3D Culture System for the Efficient Generation of MSC-Derived Functional Pancreatic β-Cells. ACS Applied Materials & Interfaces.
Fig. Graphical representation of our work: We have prepared Mxene-loaded PCL nanofibers using electrospinning technique. Onto these fibrous substrate, in presence of various bioactive factors, human Wharton's jelly Mesenchymal stem cells differentiated into mature insulin-secreting beta-cells.
Investigating to find the optimal 3D bioprinting conditions
In this study, we are working with Gelatin-Alginate based bioink formulations & using rheological studies, shape fidelity tests & bioprinting studies, we are trying find the optimal 3D printing conditions which ensures both- high shape fidelity & high cell viability.
Fig. Graphical representation of our work: Rheological studies, shape fidelity studies & 3D bioprinting studies will help us figure out the optimal bioprinting conditions.
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