Mitsuko Watabe-Uchida

Publications

Preprints

Liu, D., Rahman, M., Jonson, A., Tsutsui-Kimura, I., Pena, N., Talay, M., Logeman, B.L., Finkbeiner, S., Choi, S., Capo-Battaglia, A., Abdus-Saboor, I., Gonty, D.D., Uchida, N., Watabe-Uchida, M., Dulac, C. (2023) A hypothalamic circuit underlying the dynamic control of social homeostasis. bioRxiv 2023.05. 19.540391

Tsutsui-Kimura, Uchida, N., Watabe-Uchida, M. (2022) Dynamical management of potential threats regulated by dopamine and direct- and indirect- pathway neurons in the tail of the striatum. bioRxiv 2022.02, 05.479267

Originals

Amo, R., Uchida, N., Watabe-Uchida, M. (2024) Glutamate inputs send prediction error of reward but not negative value of aversive stimuli to dopamine neurons. Neuron 112, 1001-1019

Zhuo, Y., Luo, B., Yi, X., Dong, H., Wan, J., Cai, R., Williams, J.T., Qian, T., Cambell, M.G., Miao, X., Li, B., Wei, Y., Li, G., Wang, H., Zheng, Y., Watabe-Uchida, M., Li, Y. (2023) Improved dual-color GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods 21 (4), 680-691

Akiti, K., Tsutsui-Kimura, I., Xie, Y., Mathis, A., Markowitz, J., Anyoha, R., Datta, S.R., Weygandt Mathis, M., Uchida, N., Watabe-Uchida, M. (2022) Striatal dopamine explains novelty-induced behavioral dynamics and individual variability in threat prediction. Neuron 110 (22), 3789-3804, e9

Amo, R., Matias, S., Yamanaka, A., Tanaka, K.F., Uchida, N., Watabe-Uchida, M. (2022) A gradual temporal shift of dopamine responses mirrors the progression of temporal difference error in machine learning. Nature Neuroscience 25, 1082-1092

Tsutsui-Kimura, I., Matsumoto, H., Akiti, K., Yamada, M.M., Uchida, N., Watabe-Uchida, M. (2020) Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task. eLife 9, e62390

Kim, H., Malik, A.N., Mikhael, J.G., Bech, P., Tsutsui-Kimura, I., Sun, F., Zhang, Y., Li, Y., Watabe-Uchida, M., Gershman, S.J., and Uchida, N. (2020) A Unified Framework for Dopamine Signals across Timescales. Cell 183, 1600-1616

Menegas, W., Akiti, K., Amo, R., Uchida, N., Watabe-Uchida, M. (2018) Dopamine neurons projecting to the posterior striatum reinforce avoidance of threatening stimuli. Nature Neuroscience 21 (10), 1421

Menegas, W., Babayan, B.M., Uchida, N., Watabe-Uchida, M. (2017) Opposite initialization to novel cues in dopamine signaling in ventral and posterior striatum in mice. eLife, 6, e21886

Matsumoto, H., Tian, J., Uchida, N., Watabe-Uchida, M. (2016) Midbrain dopamine neurons signal aversion in a reward-context-dependent manner,eLife, 6 e17328

Tian, J., Huang, R., Cohen, J.Y., Osakada, F., Kodak, D., Machens, C.K., Callaway, E.M., Uchida, N., Watabe-Uchida, M. (2015) Distributed and mixed information in the monosynaptic inputs to dopamine neurons. Neuron 91, 1-16

Menegas, W., Bergan, J.F., Ogawa, S.K., Isogai, Y., Umadevi Venkataraju, K., Osten P., Uchida, N., Watabe-Uchida, M. (2015) Dopamine neurons projecting to the posterior striatum form an anatomically distinct subclass. eLife, 4, e10032

Ogawa, S.K., Cohen, J.Y., Hwang, D., Uchida, N., Watabe-Uchida, M. (2014) Organization of monosynaptic inputs to the serotonin and dopamine neuromodulatory systems. Cell Reports, 8: 1-14

Wu, Z., Autry, A.E., Nergan, J.F., Watabe-Uchida, M., Dulac, C.G. (2014) Galanin neurons in the medial preoptic area govern parental behavior. Nature 509: 325-330

Krashes, M.J., Shah, B.P., Madara, J.C., Olson, D.P., Strochlic, D.E., Garfield, A.S., Vong, L., Pei, Hongjuan, P., Watabe-Uchida, M., Uchida, N., Liberles, D., Lowell, B.B. (2014) An excitatory paraventricular nucleus to AgRP neuron circuit that drives hunger. Nature, 507: 238-242

Watabe-Uchida, M., Zhu, L., Ogawa, S. K., Vamanrao, A., Uchida, N. (2012) Whole-brain mapping of direct inputs to midbrain dopamine neurons.Neuron, 74: 858-873

Watabe-Uchida, M., John, K. A., Janas, J. A., Newey, S. E. and Van Aelst, L.  (2006).   The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18.  Neuron. 51:727-739.

Watabe-Uchida, M., Masuda, A., Shimada, N., Endo, M., Shimamura, K., Yasuda, K., and Sehara-Fujisawa, A. (2004).  Noval metalloprotease-disintegrin, meltrin e (ADAM35), expressed in epithelial tissues during chick embryogenesis.  Dev. Dyn. 230:557-568.

Watabe-Uchida, M., Uchida, N., Imamura, U., Nagafuchi, A., Fujimoto, K., Uemura, T., Vermeulen, S., van Roy, F., Adamson, E.D., and Takeichi, M. (1998).  a-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.  J. of Cell. Biol. 142:847-858.

Watabe, M. Nagafuchi, A., Tsukita, S., and Takeichi, M. (1994).  Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line.  J. of Cell. Biol. 127:247-256.

Watabe, M., Matsumoto, K., Nakamura, T., and Masatoshi, T. (1993).  Effect of hepatocyte growth factor on cadherin-mediated cell-cell adhesion.  Cell Structure and Function 18:117-124.

Reviews, Previews

Watabe-Uchida, M. (2019) The basal ganglia sensory system listens to prefrontal task needs. Neuron, 103, 353-355

Watabe-Uchida, M., Uchida, N. (2019) Multiple dopamine systems: weal and woe of dopamine. Cold Spring Harbor symposia on quantitative biology, 037648

Ogawa, S.K., Watabe-Uchida, M. (2018) Organization of dopamine and serotonin system: Anatomical and functional mapping of monosynaptic inputs using rabies virus. Pharmacology, Biochemistry and Behavior, 174, 9-22

Watabe-Uchida, M., Eshel, N., Uchida, N. (2017) Neural circuitry of reward prediction error. Annual Review of Neuroscience 40, 373-394

Menegas, W., Uchida, N., Watabe-Uchida, M. (2017) A self-killing rabies virus that leaves a trace on the DNA. Trends in Neuroscience, 40 (10), 589-591

Uchida, N., Eshel, N., Watabe-Uchida, M. (2013) Division of labor for division: inhibitory interneurons with different spatial landscapes in the olfactory system. Neuron, 80: 1106-1109

Watabe-Uchida, M., Govek, E.E., Van Aelst, L.  (2006).   Regulators of Rho GTPases in neuronal development.   J. Neurosci.  26:10633-10635.

Takeichi, M., Watabe, M., Shibamoto, S., and Ito, F. (1994).  Cadherin-dependent organization and disorganization of epithelial architecture.  The 24thInternational Symposium of the Princess Takamatsu Cancer Research Fund “Molecular and Cellular Basis for Cell Interaction: Its Significance in Cancer”, 28-37.

Takeichi, M., Watabe, M., Shibamoto, S., Ito, F., Oda, H., Uemura, T., and Shimamura, K. (1993).  Dynamic control of cell-cell adhesion for multicellular organization.  C.R. Acad. Sci. Paris 316:818-821.