Publications

[26] Positional Isomerism Tunes Molecular Reactivities and Mechanisms toward Pathological Targets in Dementia

Chanju Na, Jimin Lee, Jong-Min Suh, Jun Go, Jimin Kwak, Juri Lee, Kyoung-Shim Kim,* Chul-Ho Lee,* Mingeun Kim,* and Mi Hee Lim*

J. Am. Chem. Soc. 2026, 148, 461−473 (*Co-corresponding authors) [Full Article].

*Note: This paper was highlighted in multiple media.

[25] Spectroscopic Investigations on Metal Coordination to Amyloid-β

Mingeun Kim,* Mi Hee Lim*

Bull. Korean Chem. Soc. 2026, 46, 1066−1078 (*Co-corresponding authors) [Full Article].

*Note: This paper was featured for the KAIST Special Issue.

[24] Cobalt Complexes as Modulators against Amyloid-β Aggregation

Jeasang Yoo, Jong-Min Suh, Gunhee Kim, Hélène Bernard, Raphaël Tripier, Dongwook Kim, Mingeun Kim,* Mi Hee Lim*

J. Inorg. Biochem. 2025, 271, 112972 (*Co-corresponding authors) [Full Article].

*Note: This paper was featured for the Themed Issue on “Metal-Binding Peptides”.

[23] Interactions with Tau's Microtubule-Binding Repeats Modulate Amyloid-β Aggregation and Toxicity

Mingeun Kim, Yuxi Lin, Eunju Nam, Dong Min Kang, Sungsu Lim, Yun Kyung Kim, Young-Ho Lee, 

Mi Hee Lim 

Nat. Chem. Biol. 2025, 21, 1709-1718 [Full Article].

*Note: This paper was highlighted in multiple media.

[22] Zn(II)-Driven Impact of Monomeric Transthyretin on Amyloid-β Amyloidogenesis

Yelim Yi, Bokyung Kim, Mingeun Kim, Young Ho Ko, Jin Hae Kim, Mi Hee Lim

Chem. Sci. 2025, 16, 4366-4373 [Full Article].

[21] Distinct Aggregation Behavior of N-Terminally Truncated Aβ4-42 over Aβ1-42 in the Presence of Zn(II)

Chanju Na,† Mingeun Kim,† Gunhee Kim, Yuxi Lin, Young-Ho Lee, Wojciech Bal, Eunju Nam, Mi Hee Lim

ACS Chem. Neurosci. 2025, 16, 732-744 (†Co-first authors) [Full Article].

[20] Metal-BODIPY Complexes: Versatile Photosensitizers for Oxidizing Amyloid-β Peptides and Modulating Their Aggregation Profiles

Mingeun Kim, Gajendra Gupta, Junseong Lee, Chanju Na, Jimin Kwak, Yuxi Lin, Young-Ho Lee, Mi Hee Lim, Chang Yeon Lee 

Inorg. Chem. Front. 2024, 11, 1966-1977 [Full Article].

*Note: This paper was selected as the Journal Front Cover.

[19] APP-C31: An Intracellular Promoter of Both Metal-Free and Metal-Bound Amyloid-β40 Aggregation and Toxicity in Alzheimer's Disease

Eunju Nam, Yuxi Lin, Jiyong Park, Hyunsu Do, Jiyeon Han, Bohyeon Jeong, Subin Park, Da Yong Lee, Mingeun Kim, Jinju Han, Mu-Hyun Baik, Young-Ho Lee, Mi Hee Lim 

Adv. Sci. 2024, 11, 2307182 [Full Article].

*Note: This paper was highlighted in multiple media and appears in Hot Topic “Amyloids”.

[18] Designing Multi-Target-Directed Flavonoids: A Strategic Approach to Alzheimer's Disease

Seongmin Park,† Mingeun Kim,† Yuxi Lin, Mannkyu Hong, Geewoo Nam, Adam Mieczkowski, József Kardos, Young-Ho Lee, Mi Hee Lim

Chem. Sci. 2023, 14, 9293-9305 (†Co-first authors) [Full Article].

*Note: This paper was featured for the Themed Collection on “Celebrating the Scientific Accomplishments of RSC Fellows”, “2023 Chemical Science Hot Article Collection”, “2023 ChemSci Pick of the Week Collection”, and “2023 Chemical Science Covers”.

[17] Intercommunication between Metal Ions and Amyloidogenic Peptides or Proteins in Protein Misfolding Disorders

Jong-Min Suh,† Mingeun Kim,† Jeasang Yoo, Jiyeon Han, Cinthya Paulina, Mi Hee Lim

Coord. Chem. Rev. 2023, 478, 214978 (†Co-first authors) [Full Article].

[16] Excited-State Intramolecular Hydrogen Transfer of Compact Molecules Controls Amyloid Aggregation Profiles

Mannkyu Hong,† Mingeun Kim,† Jiwon Yoon, Seung-Hee Lee, Mu-Hyun Baik, Mi Hee Lim

JACS Au 2022, 2, 2001-2012 (†Co-first authors) [Full Article].

*Note: This paper was featured as the Supplementary Journal Cover.

[15] Redox Properties of Small Molecules Essential for Multiple Reactivities with Pathological Factors in Alzheimer's Disease

Mingeun Kim, Mi Hee Lim

Bull. Korean. Chem. Soc. 2021, 42, 1272-1280 [Full Article].

*Note: This paper was contributed to the Special Issue of “Bioinorganic Chemistry: Diverse Approaches for Elucidating the Roles of Metal Ions in Biology”.

[14] A Multi-Functional Picolinohydrazide-Based Chemosensor for Colorimetric Detection of Iron and Dual Responsive Detection of Hypochlorite

Minuk Yang, Su Chan Lee, Mingeun Kim, Mi Hee Lim, Cheal Kim

Spectrochim. Acta A Mol. Biomol. Spectrosc. 2021, 245, 118899 [Full Article].

[13] A Glycosylated Prodrug to Attenuate Neuroinflammation and Improve Cognitive Deficits in Alzheimer's Disease Transgenic Mice

Mingeun Kim,† Min Hee Park,† Geewoo Nam, Misun Lee, Juhye Kang, Im-Sook Song, Min-Koo Choi, Hee Kyung Jin, Jae-sung Bae, Mi Hee Lim

Mol. Pharmaceutics 2021, 18, 101-112 (†Co-first authors) [Full Article].

[12] A Thiourea-Based Fluorescent Chemosensor for Bioimaging Hypochlorite

Haeri So, Hangyul Lee, Gyu Dong Lee, Mingeun Kim, Mi Hee Lim, Ki-Tae Kim, Cheal Kim

J. Ind. Eng. Chem. 2020, 89, 436-441 [Full Article].

[11] Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia

Mingeun Kim,† Juhye Kang,† Misun Lee,† Jiyeon Han, Geewoo Nam, Eunyoung Tak, Min Sun Kim, Hyuck Jin Lee, Eunju Nam, Jiyong Park, Soo Jin Oh, Ji-Yoon Lee, Joo-Yong Lee,* Mu-Hyun Baik,* Mi Hee Lim* 

J. Am. Chem. Soc. 2020, 142, 8183-8193 (†Co-first authors) [Full Article].

*Note: This paper was selected as an “ACS Editors’ Choice”, highlighted in multiple media, and awarded as the “2020 Domestic Bio-field Research Achievement and News Top 5 (BRIC)”. 

[10] A Novel Thiophene-Based Fluorescent Chemosensor for the Detection of Zn2+  and CN-: Imaging Applications in Live Cells and Zebrafish 

Min Seon Kim, Dongju Yun, Ju Chae, Haeri So, Hyojin Lee, Ki-Tae Kim, Mingeun Kim, Mi Hee Lim, Cheal Kim

Sensors 2019, 19, 5458 [Full Article].

[9] N,N'-Diacetyl-p-Phenylenediamine Restores Microglial Phagocytosis and Improves Cognitive Defects in Alzheimer's Disease Transgenic Mice

Min Hee Park, Misun Lee, Geewoo Nam, Mingeun Kim, Juhye Kang, Byung Jo Choi, Min Seock Jeong, Kang Ho Park, Wan Hui Han, Eunyoung Tak, Min Sun Kim, Juri Lee, Yuxi Lin, Young-Ho Lee, Im-Sook Song, Min-Koo Choi, Joo-Young Lee, Hee Kyung Jin, Jae-sung Bae, Mi Hee Lim 

Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 23426-23436 [Full Article].

*Note: This paper was highlighted in EurekAlert and ALZFORUM.

[8] Orobol: An Isoflavone with Regulatory Multifunctionality against Four Pathological Factors of Alzheimer's Disease

Geewoo Nam, Yonghwan Ji, Hyuck Jin Lee, Juhye Kang, Yelim Yi, Mingeun Kim, Yuxi Lin, Young-Ho Lee, Mi Hee Lim

ACS Chem. Neurosci. 2019, 10, 3386-3390 [Full Article].

[7] Fluorescent Determination of Zinc by a Quinoline-Based Chemosensor in Aqueous Media and Zebrafish

Ju Byeong Chae, Dongju Yun, Sehoon Kim, Hyojin Lee, Mingeun Kim, Mi Hee Lim, Ki-Tae Kim, Cheal Kim

Spectrochim. Acta A Mol. Biomol. Spectrosc. 2019, 219, 74-82 [Full Article].

[6] Relay Detection of Zn2+ and S2- by a Quinoline-Based Fluorescent Chemosensor in Aqueous Media and Zebrafish 

Suh Mi Hwang, Dongju Yun, Hyojin Lee, Mingeun Kim, Mi Hee Lim, Ki-Tae Kim, Cheal Kim

Dyes Pigment. 2019, 165, 264-272 [Full Article].

[5] A Dual-Response Sensor Based on NBD for the Highly Selective Determination of Sulfide in Living Cells and Zebrafish

Jin Hye Kang, Minuk Yang, Dongju Yun, Mingeun Kim, Hyojin Lee, Ki-Tae Kim, Mi Hee, Lim, Cheal Kim

New J. Chem. 2019, 43, 4029-4035 [Full Article].

[4] A Near-Infrared Fluorescent Probe for Amyloid-β Aggregates 

Misun Lee,† Mingeun Kim,† Anjong Florence Tikum,† Hyuck Jin Lee, Vijayan Thamilarasan, Mi Hee Lim, Jinheung Kim

Dyes Pigment. 2019, 162, 97-103 (†Co-first authors) [Full Article].

[3] A Multiple Target Chemosensor: Fluorescent Detection of Al(III) and Colorimetric Detection of Fe(II) and Cu(II)

Dongju Yun, Ji Hye Kang, Min Seon Kim, Mingeun Kim, Mi Hee Lim, Cheal Kim

Sensor Lett. 2019, 17, 87-103 [Full Article].

[2] A Multiple Target Chemosensor for the Sequential Fluorescence Detection of Zn2+ and S2- and the Colorimetric Detection of Fe3+/2+ in Aqueous Media and Living Cells 

Jin Yeong Yun, Ju Byeong Chae, Mingeun Kim, Mi Hee, Lim, Cheal Kim

Photochem. Photobiol. Sci. 2019, 18, 166-176 [Full Article].

[1] Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease

Michael W. Beck, Jeffrey S. Derrick, Jong-Min Suh, Mingeun Kim, Kyle J. Korshavn, Richard A. Kerr, Woo Jong Cho, Scott D. Larsen, Brandon T. Ruotolo, Ayyalusamy Ramamoorthy, Mi Hee Lim

ChemMedChem 2017, 12, 1828-1838 [Full Article].

*Note: This paper was featured as the Front Cover.