Dynamic Enzymology and Enzyme Cinematography
Current Projects:
• Time-resolved XFEL and Cryo-EM
• DNA Polymerase and Photolyase
• Taiwan Cryo-EM Consortium
Recent Projects:
• Taiwan Protein Project (2016-2023)
• Academia Sinica Cryo-EM (2017-2020)
Past Research Projects:
• FHA Signaling and Phosphoproteomics
• Tumor Suppressors and Cancer Proteins
• Histone Demethylases and RBP2
• Drug Discovery against Influenza Virus
• Capsular Polysaccharide Biosynthesis of K. pneumoniae (2005-2012)
• PI-specific Phospholipase C (1992-2005)
• Phospholipase A2 (PLA2) (1988-2004)
• Adenylate Kinase (1985-96)
• Phospholipids Chiral at Phosphorus (1982-92)
• Quadrupolar NMR in Biology (1982-89)
• Chiral Phosphates (1979-84)
Recent Publication 近年主要著作
Visualizing the DNA repair process by a photolyase at atomic resolution
A novel ATP site
Temp-resolved Cryo-EM
Cryo-EM of DMC1
Cryo-EM review
Photolyase by XFEL
TIFA and leukemia
Mn2+ specificity of Pol μ
Cryo-EM in enzymology
What Others Say About Our Work