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蔡明道 Ming-Daw Tsai

IBC

IBS

Academia Sinica

Taiwan Cryo-EM

Dynamic Enzymology and Enzyme Cinematography

Complete CV

中文簡歷

Publications

Current Projects:

• Time-resolved XFEL and Cryo-EM

• DNA Polymerase and Photolyase

• Taiwan Cryo-EM Consortium

Recent Projects:

• Taiwan Protein Project (2016-2023)

• Academia Sinica Cryo-EM (2017-2020)


Past Research Projects:

• FHA Signaling and Phosphoproteomics

• Tumor Suppressors and Cancer Proteins

• Histone Demethylases and RBP2

• Drug Discovery against Influenza Virus

• Capsular Polysaccharide Biosynthesis of K. pneumoniae (2005-2012)

• PI-specific Phospholipase C (1992-2005)

• Phospholipase A2 (PLA2) (1988-2004)

• Adenylate Kinase (1985-96)

• Phospholipids Chiral at Phosphorus (1982-92)

• Quadrupolar NMR in Biology (1982-89)

• Chiral Phosphates (1979-84)

Dr. Ming-Daw Tsai

蔡明道 

mdtsai@gate.sinica.edu.tw

+886-2-2785-5696 #3070

Recent Publication 近年主要著作

A unified view on enzyme catalysis

[Commun Chem (2024)]

Cryo-EM of KtrAB

[Nature Commun (2024)]

Visualizing the DNA repair process by a photolyase at atomic resolution 

[Science (2023)]

A novel ATP site

[Nature Metabolism (2023)]

Temp-resolved Cryo-EM

[JACS (2019)]

Cryo-EM of DMC1

[Nat Commun (2021)]

Cryo-EM review

[Annu. Rev. Biophys. (2022)]

Photolyase by XFEL

[Nature Chemistry (2022)]

How DNA polymerases catalyze

replication and repair with

contrasting fidelity (2017)

TIFA and leukemia

[Cancer Research (2017)]

Mn2+ specificity of Pol μ

[JACS (2019)]

Cryo-EM in enzymology

[JACS (2019)]

 What Others Say About Our Work

Mol Cell 2008

Nat. Rev. Chem. 2017

Science 2022

Science 2023

C & E News 2001

C & E News 2002

ACS Symposium 2008

Science 2008

Science 1984

Angew. Chem. Int. Ed. 1999

Nat. Stru. Biol. 2001

Popular Science in Chinese 科普

一瞬之光 XFEL 顯微術:人類首次捕捉酵素修復 DNA 損傷的動態過程!

中央研究院 - 研之有物 2024   Link

把生物分子看得更清楚!:結構生物學最新神器 – 冷凍電子顯微鏡

中央研究院 - 研之有物 2019   Link

從化學到生物-解構蛋白質動態網絡

中研院生化所所長蔡明道專訪

科學月刊五十年大全 2009 Link

蛋白質的微觀世界 - 看見分子結構與生命的運作

科學月刊 2024-1 Link

『微小卻關鍵的補碳幫手』- 可調控固碳的藍綠箘

科學月刊 2024-4 Link

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