Off-Broadway - June 3, 2007 - MP3 (tracked) - Shaun Taylor-Corbett (u/s Usnavi), Mandy Gonzalez (Nina), Joshua Henry (u/s Benny), Karen Olivo (Vanessa), Olga Merediz (Abuela Claudia), John Herrera (Kevin), Priscilla Lopez (Camila), Robin de Jesús (Sonny), Andréa Burns (Daniela), Asmeret Ghebremichael (u/s Carla), Rickey Tripp (Grafitti Pete), Eliseo Roman (Piragua Guy)​

Off-Broadway - June 9, 2007 - Lin-Manuel Miranda (Usnavi), Mandy Gonzalez (Nina), Joshua Henry (u/s Benny), Karen Olivo (Vanessa), Olga Merediz (Abuela Claudia), John Herrera (Kevin), Priscilla Lopez (Camila), Robin de Jesús (Sonny), Andréa Burns (Daniela), Janet Dacal (Carla), Rickey Tripp (u/s Grafitti Pete), Eliseo Roman (Piragua Guy)

Broadway - November 1, 2010 - Jon Rua (u/s Usnavi), Jordin Sparks (Nina), Clifton Oliver (Benny), Gabrielle Ruiz (u/s Vanessa), Olga Merediz (Abuela Claudia), Rick Negron (Kevin), Priscilla Lopez (Camila), Noah Rivera (u/s Sonny), Andréa Burns (Daniela), Courtney Reed (Carla), Michael Balderrama (u/s Grafitti Pete)​

West End - May 10, 2016 - MP3 (tracked) - Cleve September (u/s Usnavi), Christine Allado (Vanessa), Gabriela Garcia (u/s Nina), Ryan Reid (u/s Benny), Jonny Bishop (u/s Sonny), Vas Constanti (u/s Kevin), Josie Benson (Camila), Philippa Stefani (Daniela), Sarah Naudi (Carla), Norma Atallah (Abuela), Reiss Hinds (u/s Graffiti Pete), Spin (u/s Piragua Guy).

West End - June 14, 2016 (Matinee) - Sam Mackay (Usnavi), Gabriela García (u/s Nina), Ryan Reid (u/s Benny), Christine Allado (Vanessa), Norma Atallah (Abuela Claudia), Vas Constanti (u/s Kevin), Josie Benson (Camila), Philippa Stefani (Daniela), Sarah Naudi (Carla), Michael Cortez (u/s Piragua Guy)

Kennedy Center, Washington D.C. - March 21, 2018 (Preview) (theatrecouple14's master) - Anthony Ramos (Usnavi), Ana Villafañe (Nina), J Quinton Johnson (Benny), Vanessa Hudgens (Vanessa), Saundra Santiago (Abuela Claudia), Rick Negron (Kevin), Blanca Camacho (Camila), Mateo Ferro (Sonny), Eden Espinosa (Daniela), Arianna Rosario (Carla), Virgil Gadson (Grafitti Pete), Eliseo Roman (Piragua Guy)

Australia - January 20, 2019 (revolution-trade's master) - Stevie Lopez (Usnavi), Luisa Scrofoni (Nina), Joe Kalou (Benny), Olivia Vazquez (Vanessa), Margi de Farranti (Abuela Claudia), Alexander Palacio (Kevin), Ana Maria Belo (Camila), Marty Alix (Sonny), Monique Montez (Daniela), Libby Asciak (Carla), Stephen Tannos (Grafitti Pete), Richard Valdez (Piragua Guy)