No medication to date can cure or slow the progression of knee osteoarthritis, but they help fight pain. “Paracetamol is not very effective. Weak opioids (tramadol, lamaline, codeine), which are quite effective, are not always well tolerated. Anti-inflammatory drugs are sometimes against-indicated "list P r Richette. Topicals, anti-inflammatory gels on the painful area, especially at night, are effective and without side effects.
Another possibility, the infiltrations of cortisone or hyaluronic acid (which have been delisted) in the knee joint. Intra-articular injections of anti-TNF or anti-interleukin-1 antibodies, active in inflammatory rheumatism, have no effect in knee osteoarthritis. Those of PRP (platelet rich plasma) lack convincing evaluation. “Anti-NGF antibodies show promise against pain, but they do not affect the process. Other molecules currently being tested, such as Wnt inhibitors or sprifermin, could have a protective effect on cartilage, ”explains the rheumatologist.
Non-pharmacological management should first focus on the knee. "This can involve the prescription of a knee brace, which has analgesic properties, orthoses, cushioning insoles ... each time, we gain a little on the pain, explains Prof. Rannou, specialist in physical medicine and rehabilitation. at Cochin hospital and Inserm researcher. Physiotherapy will seek to strengthen the muscles that stabilize the joint, strengthen those that oppose the overpressure on the painful part of the knee and work on proprioception, the body diagram, to counterbalance the circuits of chronic pain. But there is no place for osteopathic manipulations! ”
Another major aspect of care is the fight against a sedentary lifestyle: “Walking, cycling, swimming… Physical activity, by improving general shape, reduces pain. But we must avoid pivotal sports such as tennis, handball, football, rugby, which are more traumatic, as well as running. ” With a particular aspect, the young seniors of 60 years who want to resume sport: “It is more and more possible. We are even currently testing a knee exoskeleton that would allow patients to ski again! ” indicates the doctor.
The policy to fight against obesity in France is "proactive but poorly coordinated" , and should involve "more restrictive regulation" towards the food industry, judges the Court of Auditors in a report on prevention and in charge of obesity released Wednesday . The Court of Auditors was seized on this subject last year by the Social Affairs Commission of the National Assembly.