General Sources & Summaries
Hot Research News (MGFA)
American Journal of Managed Care (AJMC) (search for "myasthenia gravis")
Vol. 4 No. 3 (2023): Proceedings of the MGFA International Conference
Overview of MG Research and Clinical Trials (Conquer MG)
MG Research (NIH via PubMed)
Complement
Newly discovered mechanisms of action by Soliris (Eculizumab) may improve treatment outcomes
Myasthenia gravis: the role of complement at the neuromuscular junction (New York Academy of Sciences)
Complement and its role in innate and adaptive immune responses (Cell Research)
CAR-T
Povetacicept
Quality of Care and Patient Support
UK Study: Most Patients With MG Require Hospitalization, Driving Health Care Resource Use (AJMC)
Real world study on prevalence, treatment and economic burden of myasthenia gravis in Italy (Heliyon)
How physicians with poor knowledge of MG might affect care of MG patients
Healthcare resource use in myasthenia gravis: a US health claims analysis (PubMed)
An innovative partnership between Alexion, AstraZeneca Rare Disease and patients
Mental Health
Depression: A Contributing Factor to the Clinical Course in Myasthenia Gravis Patients - Abstract - Full Journal Article
Mental Health Toll Reported in Patients With Myasthenia Gravis
Patients With MG Have High Levels of Neuroticism, Study Finds
Personality factors in patients with myasthenia gravis: A prospective study
Personality traits in MG patients may underlie depression, anxiety (similar to previous link)
Others
Real-world experience with eculizumab and switching to ravulizumab for generalized myasthenia gravis (Wiley)
Abnormalities of Otoacoustic Emissions in Myasthenia Gravis: Association With Serological and Electrophysiological Features (Frontiers in Neurology) Results of this research that suggest a test for the ears that might improve the "diagnostic certainty of MG and help to monitor its severity".
Taste disorders and alopecia in myasthenia gravis (BMC Neurology)
Patient perceptions of disease burden and treatment of myasthenia gravis based on sentiment analysis of digital conversations (Nature) - An analysis of "...public domain digital conversations about MG..." from online sources such as MG forums and social media.
What's on the Horizon for Myasthenia Gravis (MedPage Today)
Antigenic mimicry of ubiquitin by the gut bacterium Bacteroides fragilis: a potential link with autoimmune disease (Clinical and Experimental Immunology)
MicroRNAs in blood may help diagnose ocular MG, study suggests (here is the original study article)
Diagnosis and Management of Seronegative Myasthenia Gravis: Lights and Shadows
The challenge of managing respiratory failure in MG patients
In Myasthenia Gravis, Antibodies Pass Open-Label Tests (rozanolixizumab (Rystiggo) and efgartigimod PH20 (Vyvgart))
GRO Biosciences’ ProGly platform shows promise in MG animal model
The ME&MG Digital Solution for Autonomous Assessment of Myasthenia Gravis
FLEX Study (to test the effectiveness and safety of batoclimab, the investigational injectable medication)
Myasthenic crisis in thymoma-associated myasthenia gravis: a multicenter retrospective cohort study
Addressing Outcome Measure Variability in Myasthenia Gravis Clinical Trials
Research and Studies to Keep an Eye On
Accuracy of Repetitive Ocular Vestibular–Evoked Myogenic Potentials to Diagnose Myasthenia Gravis in Patients With Ptosis or Diplopia (Neurology)
Immune Checkpoint Discovery Has Implications for Treating Cancer and Autoimmune Diseases (NIH)
Satralizumab (from Neuromuscular Disorders)
Results of Phase III Study of Enspryng (Satralizumab) in Patients with Generalized Myasthenia Gravis (Synapse) Also, Satralizumab Fails to Reach Expected Clinical Benefit in LUMINESCE Study of Myasthenia Gravis (NeurologyLive)
The Intricate Dance of Non-Coding RNAs in Myasthenia Gravis Pathogenesis and Treatment (Frontiers in Immunology) "Research highlights aberrant ncRNAs in MG pathogenesis, suggesting their potential as biomarkers"
FDA Greenlights NMD670 Phase 2b Trial in US Myasthenia Gravis Patients (Synapse)
$105M raised to support clinical trial of CNP-106 in gMG patients (Myasthenia Gravis News)
TOL2 tolerated well in preclinical study (Myasthenia Gravis News)
Kyverna to conduct Phase 2 trial of cell therapy KYV-101 in MG (Myasthenia Gravis News)
CABA-201 to be tested in patients with, without antibodies targeting AChR (Myasthenia Gravis News)
A biomarker for Late-Onset Myasthenia Gravis (LOMG) (Unbound Medicine)
Remission of severe myasthenia gravis after autologous stem cell transplantation (Unbound Medicine)
‘Inverse vaccine’ may reverse symptoms in autoimmune diseases... (Medical News Today)