Plant health, productivity, and soil fertility are determined by the plant-microbial interaction in the rhizosphere. The plant growth is enhanced because of the plant growth-promoting bacteria, these bacteria can protect plants from several diseases, infection, and also from abiotic stress. Endophytes are the best known suitable examples of plant growth-promoting bacteria, they help in the promotion of plant growth. They also play key roles in diverse ecosystems, including atmospheric nitrogen fixation, water uptake, solubilization, and transport of minerals from the soil to the plant. Few growth-promoting bacteria are projected as biofertilizers, biostimulants, and/or biocontrol agents to improve plant growth and productivity and thereby contribute to agricultural sustainability and food security. Nanotechnology helps to improve agricultural production by increasing the efficiency of inputs and minimizing relevant losses. Nanomaterials offer a wider specific surface area to fertilizers and pesticides. In our lab, we also emphasize searching for such endophytes which can be utilized for the improvement of crops.