Publications

2025

Cho YY*, Kim S*, Kim P, Jo MJ, Park SE, Choi Y, Jung SM#, Kang HJ#.  G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential
Biomolecules (2025) PMID: 40001594 (*Co-first author; #Corresponding author)

Kim M*, Kim SH*, Kim J, Jin EJ, Wei S, Jo Y, Oh CM, Ha KT, Roh JH, Kim WG, Cho D, Choi YJ, Jung SM#, Ryu D#.  Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism
Journal of Gineseng Research (2025) PMID: 39872286 (#Corresponding author)

2024

Ha J, Kim M, Park JS, Lee Y, Lee JY, Shin JC, Seo D, Park SS, You J, Jung SM, Kim HY, Mizuno S, Takahashi S, Kim SJ, Park SH.  SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination
Cell Reports (2024) PMID: 38347852

Cho YR*, Lee S*, Kim H*, Kim H, Roh YJ, Kim W, Jung SM#, Kim KH#.  Pinuseldarone, a Clerodane-Type Diterpene from Pinus eldarica Needles and Phytochemicals as Novel Agents for Regulating Brown Adipogenesis and Thermogenesis
Journal of Natural Products (2024) PMID: 38159296 (*Co-first author; #Corresponding author)

2023

Lee S*, Lim G*, Kim S*, Kim H, Roh YJ, Kim W, Choi DW#, Jung SM#.  Arteriovenous  Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue.
Journal of Visualized Experiments (2023) PMID: 37870308 (*Co-first author; #Corresponding author)

Park G*, Haley JA*, Le J*, Jung SM*, Fitzgibbons TP, Korobkina ED, Li H, Fluharty SM, Chen Q, Spinelli JB, Trivedi CM, Jang C, Guertin DA.  Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis.
Nature Metabolism (2023) PMID: 37337122 (*Co-first author)

Lee J, Ha J, Kim JH, Seo D, Kim M, Lee Y, Park SS, Choi D, Park JS, Lee YJ, Yang S, Yang KM, Jung SM, Hong S, Koo SH, Bae YS, Kim SJ, Park SH.  Peli3 ablation ameliorates acetaminophen-induced liver injury through inhibition of GSK3β phosphorylation and mitochondrial translocation.
Experimental and Molecular Medicine (2023) PMID: 37258579

2022

Jung SM*, Le J*, Doxsey WG*, Haley JA*, Park G, Jang C, Guertin DA.  Stable Isotope Tracing and Metabolomics to Study in vivo Brown Adipose Tissue Metabolic Fluxes.
Methods in Molecular Biology (2022) PMID: 35167094 (*Co-first author) 

Luciano AK, Korobkina E, Lyons SP, Haley JA, Fluharty S, Jung SM, Kettenbach AN, Guertin DA.  Proximity labeling of endogenous RICTOR identifies mTOR Complex 2 regulation by ADP ribosylation factor ARF1.
Journal of Biological Chemistry (2022) PMID: 35973513

Structural mechanism for regulation of Rab7 by site-specific monoubiquitination. Jung J, Baek J, Tae K, Shin D, Han S, Yang W, Yu W, Jung SM, Park SH, Choi CY, Lee S.
Int. J. Biol. Macromol (2022) PMID: 34801583 

2021

Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK, Li H, Jang C, Guertin DA.  In vivo Isotope Tracing Reveals the Versatility of Glucose as a Brown Adipose Tissue Substrate
Cell Reports (2021) Jul. PMID: 34320357 

2020

Hsiao WY, Jung SM, Tang Y, Haley JA, Li R, Li H, Martinez Calejman C, Sanchez-Gurmaches J, Hung CM, Luciano AK, DeMambro V, Wellen KE, Rosen CJ, Zhu LJ, Guertin DA.  The lipid handling capacity of subcutaneous fat is programmed by mTORC2 during development.
Cell Reports (2020) Oct. PMID: 33027655 

Martinez Calejman C, Trefely S, Entwisle SW, Luciano A, Jung SM, Hsiao W, Torres A, Hung CM, Li H, Snyder NW, Villén J, Wellen KE, Guertin DA.  mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis.
Nature Communications (2020) Jan. PMID: 31996678 

2019

Jung SM*, Hung CM*, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, Wallace M, Mukhopadhyay D, Martinez Calejman C, Luciano AK, Hsiao WY, Tang Y, Li H, Daniels DL, Mostoslavsky R, Metallo CM, Guertin DA.  Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1.
Molecular Cell (2019) Aug. PMID: 31442424 (*Co-first author) 

Seo D*, Jung SM*, Park JS, Lee J, Ha J, Kim M, Park SH.  The deubiquitinating enzyme PSMD14 facilitates tumor growth and chemoresistance through stabilizing the ALK2 receptor in the initiation of BMP6 signaling pathway.
EBioMedicine (2019) Nov. PMID: 31685442 (*Co-first author) 

Jung SM, Sanchez-Gurmaches J, Guertin DA.  Brown Adipose Tissue Development and Metabolism.
Handbook of Experimental Pharmacology (2019) PMID: 30203328 

Park JS, Kim M, Song NJ, Kim JH, Seo D, Lee JH, Jung SM, Lee JY, Lee J, Lee YS, Park KW, Park SH.  A Reciprocal Role of the Smad4-Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells.
Stem Cells. (2019) Mar. PMID: 30444564 

2018

Jung SM and Guertin DA.  Insulin PACS a Punch in SIRT1 Activity.
Molecular Cell (2018) Dec. PMID: 30576653 

Kim JH, Seo D, Kim SJ, Choi DW, Park JS, Ha J, Choi J, Lee JH, Jung SM, Seo KW, Lee EW, Lee YS, Cheong H, Choi CY, Park SH.  The deubiquitinating enzyme USP20 stabilizes ULK1 and promotes autophagy initiation.
EMBO Reports. (2018) Apr. PMID: 29487085 

2017

Lee JH *, Jung SM*, Bae E, Yang KM, Park JS, Ahn SG, Ooshima A, Park J, Shin D, Lee Y, Lee S, van Loo G, Kim SJ, Park SH.  A20 promotes metastasis of aggressive basal-like breast cancers through multi-monoubiquitylation of Snail1.
Nature Cell Biology (2017) Oct. PMID: 28892081 (*Co-first author) 

Lee P.L*, Jung SM* and Guertin D.A.  The Complex Roles of mTOR in Adipocytes and Beyond
Trends in Endocrinology and Metabolism (2017) May. PMID: 28237819 (*Co-first author) 

Lee JY, Seo D, You J, Chung S, Park JS, Lee JH, Jung SM, Lee YS, Park SH.  The deubiquitinating enzyme, ubiquitin-specific peptidase 50, regulates inflammasome activation by targeting the ASC adaptor protein.
FEBS Letters (2017) Feb. PMID: 28094437 

2015

Lee YS, Park JS, Jung SM, Kim SD, Kim JH, Lee JY, Jung KC, Mamura M, Lee SH, Kim SJ, Bae YS, Park SH.  Inhibition of lethal inflammatory responses through the targeting of membrane-associated Toll-like receptor 4 signaling complexes with a Smad6-derived peptide.
EMBO Molecular Medicine (2015) May. PMID: 25766838 

2013

Jung SM, Lee JH, Park J, Oh YS, Lee SK, Park JS, Lee YS, Kim JH, Lee JY, Bae YS, Koo SH, Kim SJ, Park SH.  Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6.
Nature Communications (2013) Oct. PMID: 24096742

Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK, Mamura M.  Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes.
EMBO Molecular Medicine (2013) Nov. PMID: 24127404

2011

Lee YS, Park JS, Kim JH, Jung SM, Lee JY, Kim SJ, Park SH.  Smad6-specific recruitment of Smurf E3 ligases mediates TGF-β1-induced degradation of MyD88 in TLR4 signalling.
Nature Communications (2011) Sep. PMID: 21897371 

Kim JH, Sung KS, Jung SM, Lee YS, Kwon JY, Choi CY, Park SH.  Pellino-1, an adaptor protein of interleukin-1 receptor/toll-like receptor signaling, is sumoylated by Ubc9.

Molecules and Cells (2011) Jan. PMID: 21120624