Embedded Files
Meek Lab at UNC
Meek Lab at UNC
25. "Stereoselective Synthesis of Alkenyl Fluorides and Alkynes by Defluoro Coupling of Trifluoromethyl Arenes" J. L. Rosario, C. Westlund, H. Keita, S. J. Meek
24. "Selective Synthesis of α,α-Difluoro- and α-Monofluoro Methylene Substituted Arenes by Defluoro C–C Bond Coupling" J. L. Rosario, H. Keita, M. Velo, S. J. Meek
DOI: 10.1021/acs.orglett.5c03667
23. "Synthesis of Quaternary and Tertiary Carbon-Substituted Arenes by Lewis Base Promoted Site-Selective Coupling with Allylic Nucleophiles" H. Keita, S. J. Meek
Angew. Chem. Int. Ed. 2023, 62, e202306277
DOI: 10.1002/anie.202306277
22. "A Catalytic Method for the Enantioselective Synthesis of α-Quaternary Ketones, α-Ketoesters and Aldehydes" E. Wheatley, J. M. Zanghi, M. M. Mason, S. J. Meek
Angew. Chem. Int. Ed. 2023, 62, e202215855
DOI: 10.1002/anie.202215855
21. "Efficient Enantio‑, Diastereo, E/Z‑, and Site-Selective NickelCatalyzed Fragment Couplings of Aldehydes, Dienes, and Organoborons" J. S. Marcum, and S. J. Meek
J. Am. Chem. Soc. 2022, 144, 19231
DOI: 10.1021/jacs.2c08742
20. "Diastereo-, Enantio-, and anti-Selective Formation of Secondary Alcohol and Quaternary Carbon Stereocenters by Cu-Catalyzed Additions of B-Substituted Allyl Nucleophiles to Carbonyls" E. Wheatley, J. M. Zanghi, S. J. Meek
19. "Synthesis of Quaternary Carbon Stereogenic Centers by Diastereoselective Conjugate Addition of Boron-Stabilized Allylic Nucleophiles to Enones" M. Z. Liang, S. J. Meek
J. Am. Chem. Soc. 2020, 142, 9925-9931
DOI: 10.1021/jacs.0c03900
18. "Enantioselective Synthesis of Functionalized Arenes by Nickel‐Catalyzed Siteselective Hydroarylation of 1,3‐Dienes with Aryl Boronates" J. S. Marcum, T. R.Taylor , S. J. Meek
Angew. Chem. Int. Ed. 2020, 59, 14070-14075
DOI: 10.1002/anie.202004982
17. "Cu-Catalyzed Diastereo-and Enantioselective Reactions of γ,γ-Disubstituted Allyldiborons with Ketones " J. M. Zanghi, S. J. Meek
Angew. Chem. Int. Ed. 2020, 59, 8451-8455
DOI: 10.1002/anie.202000675
Highlighted by Synfacts, April 2020
16. "Diastereo- and Enantioselective Synthesis of Homoallylic Amines Bearing Quaternary Carbon Centers" J. C. Green, J. M. Zanghi, S. J. Meek
J. Am. Chem. Soc. 2020, 142, 1704-1709
DOI: 10.1021/jacs.9b11529
15. "Catalytic Enantioselective Synthesis of 1,4-Keto-Alkenylboronate Esters and 1,4-Dicarbonyls" M. Z. Liang, S. J. Meek
Angew. Chem. Int. Ed. 2019, 58, 14234-14239
DOI: 10.1002/anie.201907757
14. "Enantio- and Diastereoselective Synthesis of Functionalized Carbocycles by Cu-Catalyzed Borylative Cyclization of Alkynes with Ketones" J. M. Zanghi, S. Liu, S. J. Meek
Org. Lett. 2019, 21 (13), 5172-5177
DOI: 10.1021/acs.orglett.9b01769
13. "(CDC)–Rhodium-Catalyzed Hydroallylation of Vinylarenes and 1,3-Dienes with AllylTrifluoroborates" J. S. Marcum, T. N. Cervarich, R. S. Manan, C. C. Roberts, S. J. Meek
ACS Catal. 2019, 9 (7), 5881-5889
DOI: 10.1021/acscatal.9b01579
Highlighted by Synfacts, September 2019
12. "Synthesis of Alkenyl Boronates from Epoxides with Di-[B(pin)]-methane via Pd-Catalyzed Dehydroboration" S. A. Murray, E. C. M. Luc, S. J. Meek
Org. Lett. 2018, 20 (2), pp 469–472
DOI: 10.1021/acs.orglett.7b03853
Highlighted by Synfacts, March 2018
11. "Chiral Pincer Carbodicarbene Ligands for Enantioselective Rhodium-Catalyzed Hydroarylation of Terminal and Internal 1,3-Dienes with Indoles" J. S. Marcum, C. C. Roberts, R. S. Manan, T. N. Cervarich, S. J. Meek
J. Am. Chem. Soc. 2017, 139 (44), pp 15580–15583
DOI: 10.1021/jacs.7b08575
10. "Stereoselective Tandem Bis-Electrophile Couplings of Diborylmethane" S. A. Murray, M. Z. Liang, S. J. Meek
J. Am. Chem. Soc. 2017, 139 (40), pp 14061–14064
DOI: 10.1021/jacs.7b09309
Highlighted by JACS, November 2017
Highlighted by OPRD, November 2017
Highlighted by JACS Young Investigators, August 2018
9. "Enantio- and Diastereoselective Synthesis of Hydroxy Bis(boronates) via Cu-Catalyzed Tandem Borylation/1,2-Addition" Green J. C., Joannou M. V., Murray S. A., Zanghi J. M., Meek S. J.
ACS Catal. 2017, 7, pp 4441–4445
DOI: 10.1021/acscatal.7b01123
Highlighted by Synfacts, September 2017
8. "Diastereoselective Synthesis of γ-Substituted 2-Butenolides via (CDC)-Rh-Catalyzed Intermolecular Hydroalkylation of Dienes with Silyloxyfurans" Goldfogel M. J., Roberts C. C., Manan R. S., Meek S. J.
Org. Lett. 2017, 19 (1), pp 90–93
DOI: 10.1021/acs.orglett.6b03369
Highlighted by Synfacts, February 2017
7. "Enantio- and Diastereoselective 1,2-Additions to a-Ketoesters with Diborylmethane and Substituted 1,1-Diborylalkanes" Murray S. A., Green J. C., Tailor S. B., Meek S. J.
Angew. Chem. Int. Ed. 2016, 55, 9065
DOI: 10.1002/anie.201603465
Highlighted by Synfacts, August 2016
6. "Diastereoselective synthesis of vicinal tertiary and N-substituted quaternary stereogenic centers by catalytic hydroalkylation of dienes" Goldfogel M. J., Meek S. J.
DOI: 10.1039/C5SC04908C
5. "Deducing Reaction Mechanism: A Guide for Students, Researchers, and Instructors" Meek S. J., Pitman C. L., Miller A. J. M.
J. Chem. Educ., 2016, 93 (2), pp 275–286
DOI: 10.1021/acs.jchemed.5b00160
4. "Silver(I)-Catalyzed Diastereoselective Synthesis of anti-1,2-Hydroxyboronates" Joannou M. V., Moyer B. S., Goldfogel M. J., Meek S. J.
Angew. Chem. Int. Ed. 2015, 54, 14141–14145.
DOI: 10.1002/anie.201507171
Highlighted by Synfacts, November 2015
3. "Lewis Acid Activation of Carbodicarbene Catalysts for Rh-Catalyzed Hydroarylation of Dienes" Roberts C. C., Matías D. M., Goldfogel M. J., Meek S. J.
J. Am. Chem. Soc. 2015, 137 (20), pp 6488–6491
DOI: 10.1021/jacs.5b03510
2. "Enantio- and Diastereoselective Synthesis of 1,2-Hydroxyboronates through Cu-Catalyzed Additions of Alkylboronates to Aldehydes" Joannou M. V., Moyer B. S., Meek S. J.
J. Am. Chem. Soc. 2015, 137 (19), pp 6176–6179
DOI: 10.1021/jacs.5b03477
Highlighted by Synfacts, July 2015
1. "Intermolecular Hydroamination of 1,3-Dienes Catalyzed by Bis(phosphine)carbodicarbene–Rhodium Complexes" Goldfogel M. J., Roberts C. C., Meek S. J.
J. Am. Chem. Soc. 2014, 136 (17), pp 6227–6230
DOI: 10.1021/ja502275w
Research Publications Prior to UNC
Research Publications Prior to UNC
11. "Synthesis of Z-(Pinacolato)allylboron and Z-(Pinacolato)alkenylboron Compounds through Stereoselective Catalytic Cross-Metathesis" Kiesewetter E. T.; O’Brien R. V.; Yu E. C.; Meek S. J.; Schrock R. R.; Hoveyda A. H. J. Am. Chem. Soc., 2013, 135 (16), pp 6026–6029 DOI: 10.1021/ja403188t
10. "Bipyridine Adducts of Molybdenum Imido Alkylidene and Imido Alkylidyne Complexes" Lichtscheidl A.G.; Ng V.W.L.; Müller P.; Takase M. K.; Schrock R. R.; Malcolmson S. J.; Meek S. J.; Li B.; Kiesewetter E. T.; Hoveyda A. H. Organometallics, 2012, 31 (12), pp 4558–4564 DOI: 10.1021/om300353e
9. “Catalytic Z-selective Olefin Cross-Metathesis for Natural Product Synthesis.” Meek, S. J.; O’Brien, R. V.; Llaveria, J.; Schrock, R. R.; Hoveyda, A. H. Nature 2011, 471, 461-466. DOI: 10.1038/nature09957
8. “Significance of Degenerate Metathesis Processes to Enantioselective Olefin Metathesis Promoted by Stereogenic-at-Mo Complexes,” Meek, S. J.; Malcolmson, S. J.; Li, B.; Schrock, R. R.; Hoveyda, A. H. J. Am. Chem. Soc. 2009, 131, 16407-16409. DOI: 10.1021/ja907805f
7. “Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine Oxides by Mo-Catalyzed Asymmetric Ring-Closing Metathesis,” Harvey, J. S; Malcolmson, S. J.; Dunne, K. S.; Meek, S. J.; Thompson, A. L.; Schrock, R. R.; Hoveyda, A. H.; Gouverneur, V. Angew. Chem., Int. Ed. 2009, 48, 762- 766. DOI: 10.1002/anie.200805066
6. “Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine. Catalyst Development Inspired by Natural Product Synthesis,” Sattely, E. S.; Meek, S. J.; Malcolmson, S. J.; Schrock, R. R.; Hoveyda, A. H. J. Am. Chem. Soc. 2009, 131, 943-953. DOI: 10.1021/ja8084934
5. “Highly Efficient Molybdenum-based Catalysts for Enantioselective Alkene Metathesis,” Malcolmson, S. J.; Meek, S. J.; Sattely, E. S.; Schrock, R. R.; Hoveyda, A. H. Nature 2008, 456, 933-937. DOI: 10.1038/nature07594
4. “Investigation of the Scope of an Enantioselective O→C Co-Mediated Rearrangement Reaction,” Meek, S. J.; Demont, E. H.; Harrity, J. P. A. Tetrahedron Lett. 2007, 48, 4165-4168. DOI: 10.1016/j.tetlet.2007.04.076
3. “Investigation of the Scope of a Co-Mediated O→C Ring-Contraction,” Meek, S. J.; Pradaux, F.; Carbery, D. R.; Demont, E. H.; Harrity, J. P. A. J. Org. Chem. 2007, 72, 3467-3477. DOI: 10.1021/jo0701132
2. “Development of a Stereoselective Co-Mediated Dihydropyran Ring Contraction,” Meek, S. J.; Pradaux, F.; Carbery, D. R.; Demont, E. H.; Harrity, J. P. A. Org. Lett. 2006, 8, 5597-5600. DOI: 10.1021/ol062329g
1. "Development of the Scope of a Co-Mediated O→C Rearrangement Reaction" Meek S. J.; Pradaux F.; Carbery D. R.; Demont E. H.; Harrity J. P. A. J. Org. Chem. 2005 70 (24), 10046-10056 DOI: 10.1021/jo0517895
Reviews and Book Chapters
Reviews and Book Chapters
5. "Catalytic Enantioselective Olefin Metathesis in Natural Product Synthesis. Chiral Metal-Based Complexes that Deliver High Enantioselectivity and More" Hoveyda A. H.; Malcolmson S. J.; Meek S. J.; Zhugralin A.R. Angew. Chem., Int. Ed. 2010, 49, 34-44. DOI: 10.1002/anie.200904491
4. “Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis,” Hoveyda, A. H.; Malcolmson, S. J.; Meek, S. J.; Zhugralin, A. R. in Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts; Cossy, Arseniyadis, Meyer, Eds.; VCH-Wiley, Weinheim, Germany; 2010.
3. “Catalytic Enantioselective Olefin Metathesis Reactions,” Hoveyda, A. H.; Malcolmson, S. J.; Meek, S. J.; Zhugralin, A. R. in Catalytic Asymmetric Synthesis, Third Edition; Ojima, I. Ed.; VCH-Wiley, Weinheim, Germany; 2010.
2. “O→C Rearrangements: A Powerful Strategy for the Synthesis of Functionalized Carbocycles,” Meek, S. J; Harrity, J. P. A. Tetrahedron 2007, 63, 3081–3092 DOI: 10.1016/j.tet.2007.01.004
1. "Cyclohexadienone Ketals and Quinols: Four Building Blocks Potentially Useful for Enantioselective Synthesis" Magdziak D.; Meek S. J.; Pettus T. R. R. Chem. Rev., 2004, 104 (3), pp 1383–1430 DOI: 10.1021/cr0306900
Patents
Patents
2. "Efficient Method for Z- or Cis-Selective Cross-Metathesis of Enol Ethers and Allylic Amines." Hoveyda, A. H.; Meek, S. J.; O'Brien, R. V.; Llaveria, J.; Schrock, R. R.; U.S. Provisional Patent Application No.: 61/302,412; Filing Date: 02-08-2010.
1. "Catalysts for Metathesis Reactions Including Enantioselective Olefin Metathesis, and Related Methods ," Hoveyda, A. H.; Malcolmson, S. J.; Meek, S. J.; Schrock, R. R.; International Filing Date: 23-01-2009; International Application No.: PCT/US2009/000465; Publication Date: 30-07-2009
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