2025
Jihyeon Yoon, Won-Il Choi, Won Hee Lee, Gwi Bin Lee, Byeong Wook Choi, Pyeongkeun Kim, Yerim Heo, Dong Gun Kim, Hyeon Ah Kim, Myung Ae Bae, Seong Soon Kim, Eun Young Lee, Chang-Myung Oh, Hyeok Jae Lee, Hyun Woo Kim, Wan Namkung, Hail Kim, and Jin Hee Ahn, Synthesis and Biological Evaluation of Peripheral 5HT2B Antagonists for Liver Fibrosis, Journal of Medicinal Chemistry 2025 68 (6), 6493-6506
Minhee Kim, Jihyeon Yoon, Jun Young Choi, Geumi Park, Jae-Eon Lee, Gwi Bin Lee, Byeong Wook Choi, Pyeongkeun Kim, Hail Kim, Chang-Myung Oh, Myung Ae Bae, Seong Soon Kim, Eun Young Lee, Hyeok Jae Lee, Yunmin Kim, Hyun Woo Kim, Hohjai Lee, Yong Hyun Jeon, and Jin Hee Ahn, Synthesis and Biological Evaluation of Peripheral HTR2A Antagonists for Colorectal Cancer, Journal of Medicinal Chemistry 2025 68 (2), 1716-1730
Hwang I, Nam JE, Choi W, Choi WG, Lee E, Kim H, Moon YA, Park JY, Kim H. Serotonin Regulates Lipogenesis and Endoplasmic Reticulum Stress in Alcoholic Liver Disease. Diabetes Metab J. 2025;49(4):798-811.
2024
Starkl, P., Jonsson, G., Artner, T., Turnes, B. L., Gail, L. M., Oliveira, T., Jain, A., Serhan, N., Stejskal, K., Lakovits, K., Hladik, A., An, M., Channon, K. M., Kim, H., Köcher, T., Weninger, W., Stary, G., Knapp, S., Klang, V. & Gaudenzio, N. & 5 others, Mast cell–derived BH4 and serotonin are critical mediators of postoperative pain. Sci. Immunol. 9, eadh0545 (2024)
Jeong BK, Choi WI, Choi W*, Moon J, Lee WH, Choi C, Choi IY, Lee SH, Kim JK, Ju YS, Kim P, Moon YA, Park JY*, Kim H*. A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma. Nat Commun. 2024 Aug 2;15(1):6506. (*cocorresponding author)
Ku B, Eisenbarth D, Baek S, Jeong TK, Kang JG, Hwang D, Noh MG, Choi C, Choi S, Seol T, Kim H, Kim YH, Woo SM, Kong SY, Lim DS. PRMT1 promotes pancreatic cancer development and resistance to chemotherapy. Cell Rep Med. 2024 Mar 19;5(3):101461
Pagire HS, Pagire SH, Jeong BK, Choi WI, Oh CJ, Lim CW, Kim M, Yoon J, Kim SS, Bae MA, Jeon JH, Song S, Lee HJ, Lee EY, Goughnour PC, Kim D, Lee IK, Loomba R, Kim H*, Ahn JH*. Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis. Nat Commun. 2024 Jan 20;15(1):645 (*cocorresponding author)
2023
JH Moon, J Lee, KH Kim, HJ Kim, H Kim, HN Cha, J Park, H Lee, So Park, HC Jang*, H Kim*. Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells. Exp Mol Med. 2023 Oct;55(10):2269-2280. (*cocorresponding author)
DS Lee, TH An, H Kim, E Jung, G Kim, SY Oh, JS Kim, HJ Chun, J Jung, EW Lee, BS Han, DH Han, Y Lee, TS Han, K Hur, CH Lee, DS Kim, WK Kim, JW Park, SH Koo, JK Seong, SC Lee, H Kim*, KH Bae*, KJ Oh*. Tcf7l2 in hepatocytes regulates de novo lipogenesis in diet-induced non-alcoholic fatty liver disease in mice. Diabetologia. 2023 May;66(5):931-954 (*cocorresponding author)
2022
Hong HJ, Joung KH, Kim YK, Choi MJ, Kang SG, Kim JT, Kang YE, Chang JY, Moon JH, Jun S, Ro HJ, Lee Y, Kim H, Park JH, Kang BE, Jo Y, Choi H, Ryu D, Lee CH, Kim H, Park KS, Kim HJ, Shong M. itoribosome insufficiency in β cells is associated with type 2 diabetes-like islet failure. Exp Mol Med. 2022 Jul;54(7):932- 945.
Moon JH, Oh CM, Kim H. Serotonin in the regulation of systemic energy metabolism. J Diabetes Investig. 2022 Oct;13(10):1639-1645.
Kim M, Choi W, Yoon J, Jeong BK, Pagire SH, Pagire HS, Park J, Nam JE, Oh CJ, Jeon JH, Kim SS, Lee BH, Song JS, Bae MA, Lee IK, Kim H*, Ahn JH*. Synthesis and biological evaluation of tyrosine derivatives as peripheral 5HT2Areceptor antagonists for nonalcoholic fatty liver disease. Eur J Med Chem. 2022 Sep 5;239:114517. (*cocorresponding author)
Pagire SH, Pagire HS, Park KY, Bae EJ, Kim KE, Kim M, Yoon J, Parameswaran S, Choi JH, Park S, Jeon JH, Song JS, Bae MA, Lee IK, Kim H, Suh JM, Ahn JH. Identification of New Non-BBB Permeable Tryptophan Hydroxylase Inhibitors for Treating Obesity and Fatty Liver Disease. Molecules. 2022 May 25;27(11):3417
Park K, Lim H, Kim J, Hwang Y, Lee YS, Bae SH, Kim H, Kim H, Kang SW, Kim JY, Lee MS. Lysosomal Ca2+-mediated TFEB activation modulates mitophagy and functional adaptation of pancreatic β-cells to metabolic stress. Nat Commun. 2022 Mar 14;13(1):1300. doi: 10.1038/s41467-022-28874-9.
Lee Y, Park YJ, Lee B, Park E, Kim H, Choi CW, Kim MS. Ribes fasciculatum Ameliorates High-Fat-DietInduced Obesity by Elevating Peripheral Thermogenic Signaling. Molecules. 2022 Mar 2;27(5):1649.
2021
Park J, Jeong W, Yun C, Kim H, Oh CM. Serotonergic Regulation of Hepatic Energy Metabolism. Endocrinol Metab (Seoul). 2021 Dec;36(6):1151-1160.
Won Gun Choi, Wonsuk Choi, Tae Jung Oh, Hye-Na Cha, Inseon Hwang, Yun Kyung Lee, Seung Yeon Lee, Hyemi Shin, Ajin Lim, Dongryeol Ryu, Jaemyoung Suh, So-Young Park*, Sung Hee Choi* and Hail Kim*. Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity related insulin resistance. J Clin Invest. 2021 Oct 7:e145331. (*cocorresponding author)
Sahar Waseem, Sudeep Kumar, Kanghoon Lee, Byoung-Ha Yoon, Mirang Kim, Hail Kim*, Keesook Lee*. Protein Arginine Methyltransferase 1 is Essential for the Meiosis of Male Germ Cells. In press, Int J Mol Sci. 2021 Jul 26;22(15):7951. (*cocorresponding author)
Choi WI, Yoon JH, Choi SH, Jeon BN, Kim H, Hur MW. Proto-oncoprotein Zbtb7c and SIRT1 repression: implications in high-fat diet-induced and age-dependent obesity. Exp Mol Med. 2021 May;53(5):917-932.
Kang SG, Choi MJ, Jung SB, Chung HK, Chang JY, Kim JT, Kang YE, Lee JH, Hong HJ, Jun SM, Ro HJ, Suh JM, Kim H, Auwerx J, Yi HS, Shong M. Differential roles of GDF15 and FGF21 in systemic metabolic adaptation to the mitochondrial integrated stress response. iScience. 2021 Feb 12;24(3):102181.
Park S, Kim Y, Lee J, Lee JY, Kim H, Lee S, Oh CM. A Systems Biology Approach to Investigating the Interaction between Serotonin Synthesis by Tryptophan Hydroxylase and the Metabolic Homeostasis. Int J Mol Sci. 2021 Feb 28;22(5):2452.
Bae EJ, Choi WG, Pagire HS, Pagire SH, Parameswaran S, Choi JH, Yoon J, Choi WI, Lee JH, Song JS, Bae MA, Kim M, Jeon JH, Lee IK, Kim H*, Ahn JH*. Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease. J Med Chem. 2021 Jan 28;64(2):1037-1-53 (*cocorresponding author)
2020
Park J, Eisenbarth D, Choi W, Kim H, Choi C, Lee D, Lim DS. YAP and AP-1 Cooperate to Initiate Pancreatic Cancer Development from Ductal Cells in Mice. Cancer Res. 2020 Nov 1;80(21):4768-4779.
Shong KE, Oh CM, Namkung J, Park S, Kim H. Serotonin Regulates De Novo Lipogenesis in Adipose Tissues through Serotonin Receptor 2A. Endocrinol Metab. 2020 Jun;35(2):470-479
Moon JH, Kim H, Kim H, Park J, Choi W, Choi W, Hong HJ, Ro H, Jun S, Choi SH, Banerjee RR, Shong M, Cho NH, Kim SK, German MS, Jang HC, Hail Kim. Lactation improves pancreatic β cell mass and function through serotonin production. Sci. Transl. Med. 2020 April 29; 12, eaay0455
Kim M, Hwang I, Pagire HS, Pagire SH, Choi W, Choi WG, Yoon J, Lee WM, Song JS, Yoo EK, Lee SM, Kim MJ, Bae MA, Kim D, Lee H, Lee EY, Jeon JH, Lee IK, Kim H*, Ahn JH*. Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease. J Med Chem. 2020 Apr 23;63(8):4171-4182. (*cocorresponding author)
Kim J, Kim H, Noh SH, Jang DG, Park SY, Min D, Kim H, Kweon HS, Kim H, Aum S, Seo S, Choi CS, Hail Kim, Kim JW, Moon SJ, Gee HY, Lee MG. Grasp55-/- mice display impaired fat absorption and resistance to high-fat diet-induced obesity. Nat Commun. 2020 Mar 17;11(1):1418.
Choi W, Moon JH, Hail Kim. Serotonergic regulation of energy metabolism in peripheral tissues. J Endocrinol. 2020 Apr;245(1):R1-R10.
Choi MJ, Jung SB, Lee SE, Kang SG, Lee JH, Ryu MJ, Chung HK, Chang JY, Kim YK, Hong HJ, Hail Kim, Kim HJ, Lee CH, Mardinoglu A, Yi HS, Shong M. An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models. Diabetologia. 2020 Apr;63(4):837-852.
H Kim, H Yoon, CM Oh, J Lee, K Lee, H Song, E Kim, K Y, MY Kim, H Kim, YK Kim, EH Seo, H Heo, HJ Kim, J Lee, JM Suh, SH Koo, JK Seong, S Kim, YS Ju, M Shong, M Kim, Kim H. PRMT1 is required for the maintenance of mature β cell identity. Diabetes. 2020 Mar;69(3):355-368
Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H. Serotonin Regulates Adult βCell Mass by Stimulating Perinatal β-Cell Proliferation. Diabetes. 2020 Feb;69(2):205-214.
2019
Lee K, Kim H, Lee J, Oh CM, Song H, Kim H, Koo SH, Lee J, Lim A, Kim H. Essential Role of Protein Arginine Methyltransferase 1 in Pancreas Development by Regulating Protein Stability of Neurogenin 3. Diabetes Metab J. 2019 Apr 8.
Park HS, Kim HZ, Park JS, Lee J, Lee SP, Kim H, Ahn CW, Nakaoka Y, Koh GY, Kang S. β-Cell-Derived Angiopoietin-1 Regulates Insulin Secretion and Glucose Homeostasis by Stabilizing the Islet Microenvironment. Diabetes. 2019 Apr;68(4):774-786.
2018
Kim H, Kim YG, Choi W, Moon JH, Hwang I, Kim K, Yadav VK, Karsenty G, Jeong JS, Kim H. Generation of a highly efficient and tissue-specific tryptophan hydroxylase 1 knockout mouse model. Sci Rep. 2018 Dec 5;8(1):17642.
Choi W, Namkung J, Hwang I, Kim H, Lim A, Park HJ, Lee HW, Han KH, Park S, Jeong JS, Bang G, Kim YH, Yadav V, Karsenty G, Ju JS, Choi C, Suh JM, Park JY, Park S, Kim H. Serotonin signals through a gut-liver axis to regulate hepatic steatosis. Nat Commun. 2018 Nov 16;9(1):4824
Namkung J, Shong KE, Kim H, Oh CM, Park S, Kim H. Inhibition of Serotonin Synthesis Induces Negative Hepatic Lipid Balance. Diabetes Metab J. 2018 Jun;42(3):233-243
Jung SB, Choi MJ, Ryu D, Yi HS, Lee SE, Chang JY, Chung HK, Kim YK, Kang SG, Lee JH, Kim KS, Kim HJ, Kim CS, Lee CH, Williams RW, Kim H, Lee HK, Auwerx J, Shong M. Reduced oxidative capacity in macrophages results in systemic insulin resistance. Nat Commun. 2018 Apr 19;9(1):1551.
Cui S, Park H, Park H, Mun D, Lee SH, Kim H, Yun N, Kim H, Kim M, Pak HN, Lee MH, Joung B. The Role of Serotonin in Ventricular Repolarization in Pregnant Mice. Yonsei Med J. 2018 Mar;59(2):279-286.
Kim H, Kim H, Kim K, German MS, Kim H. Ectopic serotonin production in β-cell specific transgenic mice. Biochem Biophys Res Commun. 2018 Jan 8;495(2):1986-1991.
2017
Kim YG, Moon JH, Kim K, Kim H, Kim J, Jeong JS, Lee J, Kang S, Park JS, Kim H. β-cell serotonin production is associated with female sex, old age, and diabetes-free condition.Biochem Biophys Res Commun. 2017 Nov 25;493(3):1197-120
Shen A, Kim HJ, Oh GS, Lee SB, Lee SH, Pandit A, Khadka D, Choe SK, Kwak SC, Yang SH, Cho EY, Kim HS, Kim H, Park R, Kwak TH, So HS. NAD+ augmentation ameliorates acute pancreatitis through regulation of inflammasome signalling. Sci Rep. 2017 Jun 7;7(1):3006
Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Ding L, Kim JW, Kim H, He Y, Adams RH, Koh GY. Plastic roles of pericytes in the blood-retinal barrier. Nat Commun. 2017 May 16;8:15296
Bae CY, Son J, Kim H, Park JK. Demonstration of Interposed Modular Hydrogel Sheet for Multicellular Analysis in a Microfluidic Assembly Platform. Sci Rep. 2017 May 2;7(1):1289
Chung HK, Ryu D, Kim KS, Chang JY, Kim YK, Yi HS, Kang SG, Choi MJ, Lee SE, Jung SB, Ryu MJ, Kim SJ, Kweon GR, Kim H, Hwang JH, Lee CH, Lee SJ, Wall CE, Downes M, Evans RM, Auwerx J, Shong M. Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis. J Cell Biol. 2017 Jan 2;216(1):149-165
2016
Kim Y, Kim H, Ko UH, Oh Y, Lim A, Sohn JW, Shin JH, Kim H#, Han YM#. Islet-like organoids derived from human pluripotent stem cells efficiently function in the glucose responsiveness in vitro and in vivo. Sci Rep. 2016 Oct 12;6:35145. (# cocorresponding author)
Doan KV, Kinyua AW, Yang DJ, Ko CM, Moh SH, Shong KE, Kim H, Park SK, Kim DH, Kim I, Paik JH, DePinho RA, Yoon SG, Kim IY, Seong JK, Choi YH, Kim KW. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016 Sep 29;7:12733.
Oh CM, Park S, Kim H. Serotonin as a New Therapeutic Target for Diabetes Mellitus and Obesity. Diabetes Metab J. 2016 Apr;40(2):89-98.
2015
Namkung J, Kim H#, Park S#. Peripheral Serotonin: a New Player in Systemic Energy Homeostasis. Mol Cells. 2015 Dec 31;38(12):1023-8. ( # cocorresponding author)
Hong KY, Bae H, Park I, Park DY, Kim KH, Kubota Y, Cho ES, Kim H, Adams RH, Yoo OJ, Koh GY. Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion. Development. 2015 Aug 1;142(15):2623-32.
Iida H, Ogihara T, Min MK, Hara A, Kim YG, Fujimaki K, Tamaki M, Fujitani Y, Kim H, Watada H. Expression mechanism of tryptophan hydroxylase 1 in mouse islets during pregnancy. J Mol Endocrinol. 2015 Aug;55(1):41-53
Park H, Oh CM, Park J, Park H, Cui S, Kim H, Namkung J, Park S, Pak HN, Lee MH, Kim H#, Joung B#. Deletion of the serotonin receptor type 3A in mice leads to sudden cardiac death during pregnancy. Circ J. 2015;79(8):1807-15. ( # cocorresponding author)
Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS. Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888- 93.
Oh CM, Namkung J, Go Y, Shong KE, Kim K, Kim H, Park BY, Lee HW, Jeon YH, Song J, Shong M, Yadav VK, Karsenty G, Kajimura S, Lee IK#, Park S#, Kim H#. Regulation of systemic energy homeostasis by serotonin in adipose tissues. Nat Commun. 2015 Apr 13;6:6794. (# cocorresponding author)
Kim YK, Joung KH, Ryu MJ, Kim SJ, Kim H, Chung HK, Lee MH, Lee SE, Choi MJ, Chang JY, Hong HJ, Kim KS, Lee SH, Kweon GR, Kim H, Lee CH, Kim HJ, Shong M. Disruption of CR6-interacting factor-1 (CRIF1) in mouse islet beta cells leads to mitochondrial diabetes with progressive beta cell failure. Diabetologia. 2015 Apr;58(4):771-80.
Kim K, Oh CM, Ohara-Imaizumi M, Park ,S Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty H, Nagamatsu S, German MS, Kim H. Functional role of serotoninin insulin secretion in a dietinduced insulin-resistant state. Endocrinology. 2015 Feb;156(2):444-452.
2014
Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS. Menin determines K-RAS proliferative outputs in endocrine cells. J Clin Invest. 2014 Sep 2;124(9):4093-101.
Bae CY, Min MK, Kim H#, Park JK#. Geometric effect of the hydrogel grid structure on in vitro formation of homogeneous MIN6 cell clusters. Lab Chip. 2014 Jul 7;14(13):2183-90 (# cocorresponding author)
2013
Mica Ohara-Imaizumia*, Hail Kim*, Masashi Yoshidad, Tomonori Fujiwarae, Kyota Aoyagia, Yukiko Toyofukuf, Yoko Nakamichia, Chiyono Nishiwakia, Tadashi Okamurag, Toyoyoshi Uchidaf, Yoshio Fujitanif, Kimio Akagawae, Masafumi Kakeid, Hirotaka Watadaf, Michael S. German# and Shinya Nagamatsua#. Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy. Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19420-5. (* cofirst author)
Lee HJ, Jeong SK, Na K, Lee MJ, Lee SH, Lim JS, Cha HJ, Cho JY, Kwon JY, Kim H, Song SY, Yoo JS, Park YM, Kim H, Hancock WS, Paik YK. Comprehensive Genome-Wide Proteomic Analysis of Human Placental Tissue for the Chromosome-Centric Human Proteome Project. J Proteome Res. 2013.
2012
Gregory M. Ku*, Hail Kim*, Ian Vaughn, Matthew Hangauer, Chang Myung Oh, Michael S. German, and Michael T. McManus. RNA-Seq Reveals Unique Features of the Pancreatic β-Cell Transcriptome. Molecular Endocrinolgoy, 2012 Oct;26(10):1783-92. (* cofirst author)
Kwak SH, Park BL, Kim H, German MS, Go MJ, Jung HS, Koo BK, Cho YM, Choi SH, Cho YS, Shin HD, Jang HC, Park KS: Association of Variations in TPH1 and HTR2B with Gestational Weight Gain and Measures of Obesity. Obesity. 2012 Jan;20(1):233-8
2011
Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS. Convergence of the Insulin and Serotonin Programs in the Pancreatic beta cell. Diabetes. 2011 Dec;60(12):3208-16.
Im SS, Kim MY, Kwon SK, Kim TH, Bae JS, Kim H, Kim KS, Oh GT, Ahn YH: Peroxisome proliferatoractivated receptor {alpha} is responsible for the up-regulation of hepatic glucose-6-phosphatase gene expression in fasting and db/db Mice. J Biol Chem. 286(2):1157-64, 2011
Miyatsuka T, Kosaka Y, Kim H, German MS: Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a. Proc Natl Acad Sci U S A. 108(1):185-90, 2011
2010
Hail Kim, Yukiko Toyofuku, Francis C. Lynn, Eric Chak, Toyoyoshi Uchida, Hiroki Mizukami, Yoshio Fujitani, Ryuzo Kawamori, Takeshi Miyatsuka, Yasuhiro Kosaka, Katherine Yang, Gerard Honig, Marieke van der Hart, Nina Kishimoto, Juehu Wang, Soroku Yagihashi, Laurence H. Tecott, Hirotaka Watada & Michael S. German: Serotonin regulates pancreatic beta-cell mass during pregnancy. Nat Med. 16(7):804-8, 2010
2009
Kim TH*, Kim H*, Park JM, Im SS, Bae JS, Kim MY, Yoon HG, Cha JY, Kim KS, Ahn YH: Interrelationship between LXRalsph, SREBP-1c, PPARgamma and SHP in the transcriptional regulation of glucokinase gene expression in liver. J Biol Chem, 284:15071-83, 2009 (* cofirst author)
2008
Choi KC, Oh SY, Kang HB, Lee YH, Haam S, Kim HI, Kim K, Ahn YH, Kim KS, Yoon HG: The functional relationship between co-repressor N-CoR and SMRT in mediating transcriptional repression by thyroid hormone receptor alpha. Biochem J 411:19-26, 2008
2007
Lee YH, Hong SW, Jun W, Cho HY, Kim HC, Jung MG, Wong J, Kim HI, Kim CH, Yoon HG: Anti-histone acetyltransferase activity from allspice extracts inhibits androgen receptor-dependent prostate cancer cell growth. Biosci Biotechnol Biochem 71:2712-2719, 2007
Im SS, Kwon SK, Kim TH, Kim HI, Ahn YH: Regulation of glucose transporter type 4 isoform gene expression in muscle and adipocytes. IUBMB Life 59:134-145, 2007
Kim HI, Koh YK, Kim TH, Kwon SK, Im SS, Choi HS, Kim KS, Ahn YH: Transcriptional activation of SHP by PPAR-gamma in liver. Biochem Biophys Res Commun 360:301-306, 2007
2006
Im SS, Kim SY, Kim HI, Ahn YH: Transcriptional Regulation of Glucose Sensors in Pancreatic β Cells and Liver. Current Diabetes Reviews 2(1): 11-18, 2006
Im SS, Kwon SK, Kang SY, Kim TH, Kim HI, Hur MW, Kim KS, Ahn YH: Regulation of GLUT4 gene expression by SREBP-1c in adipocytes. Biochem J 399:131-139, 2006
2005
Im SS, Kim JW, Kim TH, Song XL, Kim SY, Kim HI, Ahn YH: Identification and characterization of peroxisome proliferators response element in the mouse GLUT2 promoter. Exp Mol Med. 37(2):101-10, 2005
Im SS, Kang SY, Kim SY, Kim HI, Kim JW, Kim KS, Ahn YH: Glucose-Stimulated Upregulation of GLUT2 Gene Is Mediated by Sterol Response Element-Binding Protein-1c in the Hepatocytes. Diabetes 54(6):1684-91, 2005
2004
Kim SY*, Kim HI*, Park SK, Im SS, Li T, Cheon HG, Ahn YH: Liver glucokinase can be activated by peroxisome proliferator-activated receptor-g. Diabetes 53 Suppl 1:S66-70, 2004 (* cofirst author)
Kim SY*, Kim HI*, Kim TH, Im SS, Park SK, Lee IK, Kim KS, Ahn YH: SREBP-1c mediates the insulin dependent hepatic glucokinase expression. J Biol Chem 279: 30823-9, 2004 (* cofirst author)
Kim HI, Ahn YH: Role of peroxisome proliferator-activated receptor-gamma in the glucose-sensing apparatus of liver and beta-cells. Diabetes 53 Suppl 1:S60-65, 2004
Choi YH, Kim HI, Seong JK, Yu DY, Cho H, Lee MO, Lee JM, Ahn YH, Kim SJ, Park JH: Hepatitis B virus X protein modulates peroxisome proliferator-activated receptor g through protein-protein interaction. FEBS Lett 557:73-80, 2004
2002
Kim JA, Park KS, Kim HI, Oh SY, Ahn YH, Oh JW, Choi KY: Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells. Cancer Lett 179:185-195, 2002
Kim HI, Cha JY, Kim SY, Kim JW, Roh KJ, Seong JK, Lee NT, Choi KY, Kim KS, Ahn YH: Peroxisomal proliferator-activated receptor-g upregulates glucokinase gene expression in beta-cells. Diabetes 51:676-685, 2002.
Cha JY, Kim HS, Kim HI, Im SS, Kim SY, Kim JW, Yeh BI, Ahn YH: Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity. Ann Clin Lab Sci 32:114- 122, 2002
2001
Cha JY, Kim HI, Im SS, Li TZ, Ahn YH: HNF1 and/or HNF3 may contribute to the tissue specific expression of glucokinase gene. Exp Mol Med 33:59-63, 2001
2000
Kim HI, Kim JW, Kim SH, Cha JY, Kim KS, Ahn YH: Identification and functional characterization of the peroxisomal proliferator response element in rat GLUT2 promoter. Diabetes 49:1517-1524, 2000
Cha JY, Kim HI, Kim KS, Hur MW, Ahn YH: Identification of transacting factors responsible for the tissuespecific expression of human glucose transporter type 2 isoform gene. Cooperative role of hepatocyte nuclear factors 1a and 3b. J Biol Chem 275:18358-18365, 2000