2025
Jeong Y, Oh AR, Jung YH, Jung KH, Lee S, Carrer M, Lee SB, Valenti L, Pajvani UB, Kim K*. Hepatocyte KCTD17-mediated SERPINA3 inhibition determines liver fibrosis in metabolic dysfunction-associated steatohepatitis. Experimental & Molecular Medicine. 2025 Aug 1. In press. (*Corresponding author)
Bouska A, Zhang W, Sharma S, Holte H, Shah RA, Lone WG, Soma MA, Yang R, Liu X, Mehmood S, Chawla RS, Cappelli LV, Fiore D, Gong Q, Heavican-Foral TB, Cannatella JJ, Amador C, Arif A, Smith LM, Lim ST, Ong CK, Feldman AL, Du MQ, Perry AM, de Leval L, Greiner TC, Fu K, Trøen G, Vodák D, Nakken S, Delabie J, Weinstock D, Pileri S, Laginestra A, Kim K, Pajvani UB, Vose JM, Weisenburger DD, Horwitz SM, Dave S, Khoury J, Inghirami G, Chan WC, Iqbal J. Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T-Cell Lymphoma. American Journal of Hematology. 2025 Jun 13. doi: 10.1002/ajh.27736 .
Choi YU#, Kim YU#, Gi H#, Kim DW#, Lee SB*, Kim K*. SERPINA3 as a modulator of skin cell functionality in human dermal fibroblasts. BMB Reports. 2025 Jun;58(6):264-268 (#Co-first author; *Corresponding author)
Lee SB, Kim K*. Correspondence to editorial on "KCTD17-mediated Ras stabilization promotes hepatocellular carinoma progression". Clinical and Molecular Hepatology. 2025 Jan; 31(1):e78-e80 (*Corresponding author)
2024
Jung YH#, Lee YJ#, Dao T, Jung KH, Yu J, Oh AR, Jeong Y, Gi H, Kim YU, Ryu D, Carrer M, Pajvani UB, Lee SB*, Hong SS*, Kim K*. KCTD17-mediated Ras stabilization promotes hepatocellular carcinoma progression. Clinical and Molecular Hepatology. 2024 Oct; 30(4): 895-913 (#Co-first author; *Corresponding author)
Kim YU#, Gi H#, Jeong EK#, Han S, Seo WY, Kim YJ*, Lee SB*, Kim K*. Development of a highly effective recombinant protein from Human Collagen Type III Alpha 1 (COL3A1) to enhance human skin cell functionality. BMB Reports. 2024 Sep;57(9):424-429 (#Co-first author; *Corresponding author)
Baek S#, Seo DS#, Kang J, Ahmad Y, Park S, Joo S, Kim K, Jang Y. ChREBP plays a pivotal role in the nutrient-mediated regulation of metabolic gene expression in brown adipose tissue. Life Sciences. 2024 Jun 15;351:122843
Kang D, Hwang HJ, Baek Y, Sung JY, Kim K, Park HJ, Ko YG, Kim YN, Lee JS. TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma. Cell Death Dis. 2024 Jan 10;15(1):26
2023
Kim K*, Lee SB*. Regulation of CMGC kinases by hypoxia. BMB Reports. 2023 11;56(11):584-593 (*Corresponding author)
Jeong Y#, Oh AR#, Jung YH#, Gi H, Kim YU, Kim K*. Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy for metabolic diseases. Experimental & Molecular Medicine. 2023;55(10):2097-2104 (#Co-first author; *Corresponding author)
Jiang Y, Wei S, Koo JM, Kim HJ, Park W, Zhang Y, Guo H, Ha KT, Oh CM, Kang JS, Jeong JH, ,Ryu D, Kim K*, Jo Y*. Integrative evaluation of the clinical significance underlying protein arginine methyltransferases in hepatocellular carcinoma. Cancers. 2023;15(16):4183 (*Corresponding author)
Shin MC#, Jung YH#, Jeong Y, Oh AR, Lee SB, Kim K*. Kctd17-mediated Chop degradation promotes adipogenic differentiation. Biochem Biophys Res Commun. 2023 Apr; 653:126-132 (#Co-first author; *Corresponding author)
Oh AR#, Jeong Y#, Yu J, Tam DHM, Kang JK, Jung YH, Im SS, Lee SB, Ryu D, Pajvani UB*, Kim K*. Hepatocyte Kctd17 inhibition ameliorates glucose intolerance and hepatic steatosis caused by obesity-induced Chrebp stabilization. Gastroenterology. 2023 Mar;164(3):439-453 (#Co-first author; *Corresponding author)
Kang J, Postigo-Fernandez J, Kim K, Zhu C, Yu J, Meroni M, Mayfield B, Bartolome A, Dapito DH, Ferrante A, Dongiovanni P, Valenti L, Creusot RJ, Pajvani UB. Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis. JCI Insight. 2023 Feb 8;8(3):e165369
2022
Lee SB, Garofano L, Ko A, D’Angelo F, Frangaj B, Sommer D, Gan Q, Kim K, Cardozo T, Iavarone A, Lasorella A. Regulated interaction of ID2 with the anaphase-promoting complex links progression through mitosis with reactivation of cell-type-specific transcription. Nature Communications. 2022 Apr 19;13(1):2089
2021
Cha JH#, Jeong Y#, Oh AR#, Lee SB, Hong SS, Kim K*. Emerging roles of PHLPP phosphatases in metabolism. BMB Reports. 2021 Aug 6:5412 (#Co-first author; *Corresponding author)
Yu J, Zhu C, Wang X, Kim K, Bartolome A, Dongiovanni P, Yates KP, Valenti L, Carrer M, Sadowski T, Qiang L, Tabas I, Lavine JE, Pajvani UB. Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch1 signaling to determine NASH-induced fibrosis. Science Translational Medicine. 2021 Jun 23;13(599):eabe1692
Hwang SJ, Kim SH, Seo WY, Jeong Y, Shin M, Ryu D, Lee SB, Choi YJ*, Kim K*. Effects of human collagen a-1 type I-derived proteins on collagen synthesis and elastin production in human dermal fibroblasts. BMB Reports. 2021 Jun;54(6):329-334 (*Corresponding author)
Kim K*, Kang JK, Jung YH, Lee SB, Rametta R, Dongiovanni P, Valenti L, Pajvani UB. Adipocyte PHLPP2 inhibition prevents obesity-induced fatty liver. Nature Communications. 2021 Mar 23;12(1):1822 (*Corresponding author)
2020
Hwang SJ, HA GH, Seo WY, Kim CK, Kim K*, Lee SB*. Human collagen alpha-2 type I stimulates collagen synthesis, wound healing, and elastin production in normal human dermal fibroblasts (HDFs). BMB Reports. 2020 Nov;53(10):539-544 (*Corresponding author)
Kim K, Yang WH, Jung YS, Cha JH. A new aspect of an old friend: the beneficial effect of metformin on anti-tumor immunity. BMB Reports. 2020 Nov;53(10):512-520
Kim K*, Yu J, Kang JK, Morrow JP, Pajvani UB*. Liver-selective g-secretase inhibition ameliorates diet-induced hepatic steatosis, dyslipidemia and atherosclerosis. Biochem Biophys Res Commun. 2020 Jul 5;527(4):979-984 (*Corresponding author)
Kim K*, Kim KH*. Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH). Int J Mol Sci. 2020 Mar 26;21(7):2296 (*Corresponding author)
2018
Zhu C, Kim K, Wang X, Bartolome A, Salomao M, Dongiovanni P, Meroni M, Graham MJ, Yates KP, Diehl AM, Schwabe RF, Tabas I, Valenti L, Lavine JE, Pajvani UB. Hepatocyte Notch activation induces liver fibrosis in NASH. Science Translational Medicine 2018 Nov 21; 10(468). pii: eaa0344
Son NH, Basu D, Samovski D, Pietka TA, Peche VS, Willecke F, Fang X, Yu SQ, Scerbo D, Chang HR, Sun F, Bagdasarov S, Drosatos K, Yeh ST, Mullick AE, Shoghi KI, Gumaste N, Kim K, Huggins LA, Lhakhang T, Abumrad NA, Goldberg IJ. Endothelial cell CD36 optimizes tissue fatty acid uptake. Journal of Clinical Investigation 2018 Oct 1; 128(10): 4329-4342
Kim K, Goldberg IJ, Graham MJ, Sundaram M, Bertaggia E, Lee SX, Qiang L, Haeusler RA, Metzger D, Chambon P, Yao Z, Ginsberg HN, Pajvani UB. Gamma-secretase inhibition lowers plasma triglyceride-rich lipoproteins by stabilizing the LDL receptor. Cell Metabolism 2018 Apr 3; 27(4): 816-827.e4
2017
Kim K, Ryu D, Dongiovanni P, Ozcan L, Nayak S, Ueberheide B, Valenti L, Auwerx J, Pajvani UB. Degradation of PHLPP2 by KCTD17, via a Glucagon-dependent Pathway, Promotes Hepatic Steatosis. Gastroenterology 2017. Dec;153(6):1568-1580.e10
2016
Kim K, Pajvani UB. “Free” Raptor – a novel regulator of metabolism. Cell Cycle 2016. May 2;15(9):1174-5
Kim K, Qiang L, Hayden MS, Sparling D, Purcell N, Pajvani UB. mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2. Nature Communications 2016. Jan 8;7:10255
2015
Sparling DP, Yu J, Kim K, Zhu C, Brachs S, Birkenfeld AL, Pajvani UB. Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity. Molecular Metabolism 2015. Dec 2;5(2):113-21
2012
Kim K, Pyo S, Um SH. S6K2 deficiency enhances ketone body production and increases PPARalpha activity in the liver. Hepatology 2012 Jun;55(6):1727-37
2010
Kim K*, Kim KH*, Cho HK, Kim HY, Kim HH, Cheong J. The small heterodimeric partner suppresses the transcriptional activities and nuclear translocation of hedgehog signaling protein Gli1. Biochemical Journal 2010. Apr 14;427(3):413-22
Kim K, Kim HY, Cho HK, Kim KH, Cheong J. The SDF-1{alpha}/CXCR4 axis induces the expression of fatty acid synthase via sterol regulatory element binding protein-1 activation in cancer cells. Carcinogenesis 2010. Apr 31;4:679-86
Kim K, Kim KH, Cheong J. Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3. PLoS One 2010. Mar 23;5;3:e8649
Kim K, Kim KH, Kim HY, Cho HK, Sakamoto N, Cheong J. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS Letters 2010. Feb 19;584(4):707-12
2009
Kim K, Kim HY, Son EJ, Heo J, Cheong J. Oleic acid inhibits hepatic insulin signaling through deregulation of STAT3 activation and C/EBPalpha expression. Cellular Signalling 2009. Aug;21(8):1269-76
Kim K, Choi YH, Kim HH, Cheong J. The orphan nuclear receptor SHP inhibits apoptosis during the monocytic differentiation by inducing p21WAF1. Experimental and Molecular Medicine 2009. Jun 30;41(6):429-39
Park MJ, Kim HY, Kim K, Cheong J. Homeodomain transcription factor CDX1 is required for the transcriptional induction of PPARgamma in intestinal cell differentiation. FEBS Letters 2009. Jan 5;583(1):29-35
2008
Kim K, Kim KH, Kim HH, Cheong J. Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRalpha. Biochemical Journal 2008. Dec 1;416(2):219-30
Park MJ, Kim KH, Kim HY, Kim K, Cheong J. Bile acid induces expression of COX-2 through the homeodomain transcription factor CDX1 and orphan nuclear receptor SHP in human gastric cancer cells. Carcinogenesis 2008. Dec;29(12):2385-93
2007
Kim K, Kim HH, Kim JH, Choi YH, Kim YH, Cheong JH. Chemokine stromal cell-derived factor-1 induction by C/EBPbeta activation is associated with all-trans-retinoic acid-induced leukemic cell differentiation. Journal of Leukocyte Biology 2007. Nov;82(5):1332-9
Kim KH*, Shin HJ*, Kim K, Choi HM, Rhee SH, Moon HB, Kim HH, Yang US, Yu DY, Cheong J. Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma. Gastroenterology 2007 May;132(5):1955-67
Kim KH, Hong SP, Kim K, Park MJ, Kim KJ, Cheong J. HCV core protein induces hepatic lipid accumulation by activating SREBP1 and PPARgamma. Biochemical and biophysical research communications 2007. Apr 20;355(4):883-8
Metabolic Disease Network Laboratory
Department of Biomedical Sciences, College of Medicine, Inha University
Room 310B, 60th Anniversary Hall, 100 Inha-ro, Incheon 22212, Republic of Korea