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The McAtamney Lab is primarily interested in studying natural products (NPs), otherwise known as specialized or secondary metabolites. NPs are classified as any molecule produced by a living organism, such as plants, bacteria, or fungi. The group sits on the interface of microbiology and analytical chemistry, combining tools from each to identify and isolate antibacterial compounds from microbial extracts. Due to nature’s ability to produce unique chemical scaffolds, NPs serve as a rich source of potential antibiotic compounds.
The McAtamney lab uses an interdisciplinary approach to identify microbially-produced antibiotics, including microbiology sterile techniques, liquid chromatography-tandem mass spectrometry (LC-MS/MS), and nuclear magnetic resonance (NMR).
Antibiotic discovery from soil and freshwater marine microbes
Antibiotic discovery from soil and freshwater marine microbes
Mount Holyoke College has a rich source of biodiversity situated right on campus at The Campus Living Laboratory. In collaboration with The Miller Worley Center for the Environment, we are collecting samples from the soil and upper and lower ponds, culturing them, and isolating bacteria that exhibit antibiotic activity. Mass spectrometry-based methods will be used to identify potential novel antibiotic compounds from microbial extracts.
We are looking for collaborations! Our expertise is in LC-MS/MS and untargeted metabolomics. If you have an interest in collaborating, please contact Allyson!
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