Present Projects

• Project-1
  Title: Comprehensive analysis of fetal nuchal edema in mice.

Description: Fetal nuchal edema, characterized by subcutaneous fluid accumulation in the fetal neck, is a critical condition associated with chromosomal anomalies and developmental abnormalities in humans. Despite its clinical significance, the underlying genetic causes and pathogenesis remain unclear in many cases. Our project focuses on leveraging mouse models to investigate the genetic and molecular mechanisms driving fetal nuchal edema. Mouse models provide a powerful tool to replicate the condition and analyze its implications for fetal prognosis and potential adult-onset diseases. Using advanced technologies, including next-generation sequencing and the CRISPR/Cas9 system, we aim to identify novel causative genes and unravel the complex pathways involved. This research will contribute to improving diagnostic accuracy and broadening our understanding of the genetic factors underlying fetal nuchal edema, with potential implications for human medicine.

• Project-2
  Title: Advanced Drug Design (CADD) against different human diseases with In-silico screening.

Description: Neurodegenerative illnesses, including Alzheimer's Disease (AD) and Parkinson's Disease (PD), present substantial worldwide health issues, requiring the creation of innovative therapeutic strategies. This study examines the efficacy of natural phytocompounds, such as Baicalein, Vincarubine, Rutin, and Luteolin, as prospective treatments for Alzheimer's disease and Parkinson's disease. Molecular docking and dynamics simulations demonstrated their enhanced binding affinities and stability with critical proteins associated with these illnesses, including Leucine-Rich Repeat Kinase 2 (LRRK2), Amyloid-beta precursor protein (APP), and Human Tau Protein Kinase. Rutin exhibited superior stability in simulations, establishing robust hydrogen bonds and sustaining low Root Mean Square Deviation (RMSD) values. Vincarubine had significant binding affinities while exhibiting increased conformational flexibility, indicating possibilities for further structural optimization. Pharmacokinetic research revealed that the majority of compounds conformed to Lipinski’s Rule of Five; nevertheless, Rutin and Vincarubine posed difficulties with molecular weight and blood-brain barrier permeability, underscoring the necessity for sophisticated delivery mechanisms. Toxicity evaluations highlighted the safety of these phytocompounds, with Rutin and Baicalein exhibiting neither neurotoxicity nor carcinogenicity, in contrast to some reference medications. 

• Project-3

Title: Postmortem and laboratory based prevalence of Bovine Tuberculosis in slaughter markets of Bangladesh.

Description: Bovine tuberculosis (bTB) is a chronic infectious disease that poses significant health and economic challenges in livestock production and zoonotic transmission to humans. This project aims to determine the prevalence of bTB in cattle at slaughter markets across Bangladesh through postmortem examinations and laboratory diagnostics. By combining field-based observations with advanced laboratory techniques, the study seeks to identify infection rates, risk factors, and potential hotspots for disease transmission. The findings will contribute to improving bTB control strategies, safeguarding public health, and enhancing livestock productivity in Bangladesh. 

• Project-4

Title: Bovine mastitis in Bangladesh.

Description: Bovine mastitis, a significant disease affecting dairy cattle, poses serious challenges to livestock productivity and farmer livelihoods in Bangladesh. This project is dedicated to investigating the prevalence, risk factors, and antibiogram patterns of major pathogens associated with mastitis in cattle. By identifying the causative agents and their antibiotic resistance profiles, we aim to provide actionable insights for effective disease management and treatment strategies.

Additionally, this research focuses on assessing the financial and economic impact of mastitis on dairy farms, including losses in milk production, veterinary costs, and the broader implications for the dairy industry. By combining epidemiological and economic analyses, this project seeks to provide a holistic understanding of bovine mastitis, ultimately contributing to improved animal health, farm profitability, and sustainable dairy farming in Bangladesh.

• Project-5

Title: Protozoal diseases in Bangladesh.

Description: This project focuses on understanding the impact of protozoal infections, particularly Toxoplasma gondii and Neospora caninum, in livestock across Bangladesh. By investigating their prevalence and identifying key risk factors, the project aims to shed light on the epidemiological aspects of these protozoal diseases. Advanced molecular detection techniques are employed to provide accurate diagnostics, which will help in formulating effective control and prevention strategies. This study holds significant importance for safeguarding livestock health and mitigating the economic losses associated with protozoal infections. 

• Project-6 (New)

Title: Development and Characterization of Co-crystals Assisted with In-silico Screening of plant herbs like Harmala, Curcumin.

Description: Continued soon................