CRISPR editing of genomic regulatory elements with the intention of direct exon/intron splicing is a hopeful means of everlastingly alleviating genetic diseases. Cas9-induced DNA double-stranded break, non-homologous end-joining repair pathways frequently introduce variable indel mutations at the cut site. Circadian rhythms control cell proliferation and differentiation, however circadian control of Human induced pluripotent stem cells (hiPSCs) remains study at the molecular level.

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