Publications

Full list of publications: Google Scholar l Pubmed

* equally contributed      # corresponding author

2024


J. Sapudom*, A. Alatoom*, P.S. Tipay, J. Teo, Matrix fibril alignment and density modulate YAP-mediated T-cell immune suppression. (BioArxiv)
N. Prigyai, T. Bunchuay, A. Ruengsuk, N. Yoshinari, J. Manissorn, P. Pumirat, J. Sapudom, P. Kosiyachinda, P. Thongnuek, Photo-Controlled Reversible Uptake and Release of a Modified Sulfamethoxazole Antibiotic Drug from a Pillar[5]arene Cross-Linked Gelatin Hydrogel, ACS Appl Mater Interfaces  (2024).

2023


J. Sapudom, S. Karaman, B.C. Quartey, W.K.E. Mohamed, N. Mahtani, A. Garcia‐Sabaté, J. Teo, Collagen Fibril Orientation Instructs Fibroblast Differentiation Via Cell Contractility, Advanced Science. 10 (2023) 2301353. 
P. Riedl*, J. Sapudom*, C. Clemens, L. Orgus, A. Pröger, J.C.M. Teo, T. Pompe, Phenotype Switching of Breast Cancer Cells upon Matrix Interface Crossing, ACS Appl. Mater. Interfaces. 15 (2023) 24059–24070. 
B.C. Quartey*, J. Sapudom*, M. ElGindi, A. Alatoom, J. Teo, Matrix-Bound Hyaluronan Molecular Weight as a Regulator of Dendritic Cell Immune Potency, Adv Healthc Mater  (2023) e2303125.
M. ElGindi, J. Sapudom, A. Garcia Sabate, B.C. Quartey, A. Alatoom, M. Al-Sayegh, R. Li, W. Chen, J. Teo, Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity, Npj Aging. 9 (2023) 14. 
J. Sapudom*,#, M. Kongsema*, A. Methachittipan, S. Damrongsakkul, S. Kanokpanont, J.C.M. Teo, M. Khongkow, K. Tonsomboon, P. Thongnuek, Degradation products of crosslinked silk fibroin scaffolds modulate the immune response but not cell toxicity, J. Mater. Chem. B. 11 (2023) 3607–3616.
A. Alatoom, M. ElGindi, J. Sapudom, J.C.M. Teo, The T Cell Journey: A Tour de Force, Adv. Biol. 7 (2023) 2200173. 

2022


M. ElGindi, J. Sapudom, P. Laws, A. Garcia-Sabaté, M.F. Daqaq, J. Teo, 3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome, Cell. Mol. Life Sci. 79 (2022) 508. 

2021


Sapudom, J.; Karaman, S.; Mohamed, W.K.E.; Garcia-Sabaté, A.; Quartey, B.C.; Teo, J. 3D in vitro M2 macrophage model to mimic modulation of tissue repair, npj Regenerative Medicine 2021, 6,83 .
Sapudom, J.*; Elgindi, M.*; Arnoux, M.; Drou, N.; Garcia-Sabaté, A.; Teo, J. Fibroblast Differentiation and Matrix Remodeling Impaired under Simulated Microgravity in 3D Cell Culture Model, Int. J. Mol. Sci. 2021, 22, 11911.
ElGindi, M.; Sapudom, J.; Ibrahim, I.H.; Al-Sayegh, M.; Chen, W.; Garcia-Sabaté, A.; Teo, J.C.M. May the Force Be with You (Or Not): The Immune System under Microgravity. Cells 2021, 10, 1941.
Elgindi, M.; Ibrahim I.H..; Sapudom, J.; Garcia-Sabaté, A.; Teo, J.. Engineered Microvessel for Cell Culture in Simulated Microgravity. Int. J. Mol. Sci. 2021, 22, 6331.
Hallfors, N.; Shanti, A.; Sapudom, J.;  Teo, J.; Petroianu, G.; Lee, S.; Planelles, L.; Stefanini, C. Multi-Compartment Lymph-Node-On-A-Chip Enables Measurement of Immune Cell Motility in Response to Drugs. Bioengineering 2021, 8, 19.

2020


Menachery, A.*; Sapudom, J.*; Vembadi, A.; Alatoom, A.; Teo, J.; Qasaimeh, M.A. Dielectrophoretic characterization of dendritic cell deformability upon maturation. BioTechniques. 2020, 70, 29-36.
Bahmad, H.F.; Daouk, R.; Azar, J.; Sapudom, J.; Teo, J.C.M. ; Abou-Kheir, W.; Al-Sayegh, M. Modeling Adipogenesis: Current and Future Perspective. Cells. 2020, 9, 2326. 
Sapudom, J.#; Müller, C.D.; Nguyen, K.T.; Martin, S.; Anderegg, U.; Pompe, T. Matrix Remodeling and Hyaluronan Production by Myofibroblasts and Cancer-Associated Fibroblasts in 3D Collagen Matrices. Gels 2020, 6, 33.
Garcia-Sabaté, A.; Mohamed, W.K.E.; Sapudom, J.; Alatoom, A.; Al Safadi, L.; Teo, J.C.M. Biomimetic 3D models for investigating the role of monocytes and macrophages in atherosclerosis. Bioengineering. 2020, 7, 113.
Sapudom, J.; Alatoom, A.; Mohamed, W.K.E.; Garcia-Sabaté, A.; McBain, I.; Nasser, R.; Teo, J.C.M. Dendritic cell immune potency on 2D and in 3D collagen matrices. Biomater. Sci. 2020, 8,  5106-5120.
Shanti, A.; Samara, B.; Abdullah, A.; Hallfors, N.; Accoto, D.; Sapudom, J.; Alatoom, A.; Teo, J.; Danti, S.; Stefanini, C. Multi-Compartment 3D-Cultured Organ-on-a-Chip: Towards a Biomimetic Lymph Node for Drug Development. Pharmaceutics 2020, 12, 464.
Seo, B.R.; Chen, X.; Song, Y.H.; Ling, L.; Choi, S.; Gonzalez, J.; Sapudom, J.; Wang, K.; Andresen Eguiluz, R.C.; Gourdon, D.; Shenoy V.B.; Fischbach C. Collagen Microarchitecture Mechanically Controls Myofibroblast Differentiation. Proc. Natl. Acad. Sci. 2020, 201919394.
Sapudom, J.*; Mohamed, W.K.E.*; Garcia-Sabaté, A.; Alatoom, A.; Karaman, S.; Mahtani, N.; Teo, J.C.M. Collagen fibril density modulates macrophage activation and cellular functions during tissue repair. Bioengineering 2020, 7, 33.
Sapudom, J.*; Nguyen, K.T.*; Martin, S.; Wippold, T.; Möller, S.; Schnabelrauch, M.; Anderegg, U.; Pompe, T. Biomimetic tissue models reveal the role of hyaluronan in melanoma proliferation and invasion. Biomater. Sci. 2020, 8, 1405–1417.
Alatoom, A.*; Sapudom, J.*; Soni, P.; Mohamed, W.K.E.; Garcia‐Sabaté, A.; Teo, J. Artificial Biosystem for Modulation of Interactions between Antigen‐Presenting Cells and T Cells. Adv. Biosyst. 2020, 2000039

2019


Sapudom, J.; Kalbitzer, L.; Wu, X.; Martin, S.; Kroy, K.; Pompe, T. Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells. Biomaterials 2019, 193, 47–57.
Witzel, I.I.; Nasser, R.; Garcia-Sabaté, A.; Sapudom, J.; Ma, C.; Chen, W.; Teo, J.C.M. Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering. Adv. Healthc. Mater. 2019, 8, 1801126.

2018


Sapudom, J.; Pompe, T. Biomimetic tumor microenvironments based on collagen matrices. Biomater. Sci. 2018, 6, 2009–2024.
Kräter, M.*; Sapudom, J.*; Bilz, N.; Pompe, T.; Guck, J.; Claus, C. Alterations in Cell Mechanics by Actin Cytoskeletal Changes Correlate with Strain-Specific Rubella Virus Phenotypes for Cell Migration and Induction of Apoptosis. Cells 2018, 7, 136.

2017


Sapudom, J.*; Waschke, J.*; Franke, K.; Hlawitschka, M.; Pompe, T. Quantitative label-free single cell tracking in 3D biomimetic matrices. Sci. Rep. 2017, 7, 14135.
Ansorge, M.; Sapudom, J.; Chkolnikov, M.; Wilde, M.; Anderegg, U.; Möller, S.; Schnabelrauch, M.; Pompe, T. Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks. Sci. Rep. 2017, 7, 5664.
Sapudom, J.; Wu, X.; Chkolnikov, M.; Ansorge, M.; Anderegg, U.; Pompe, T. Fibroblast fate regulation by time dependent TGF-β1 and IL-10 stimulation in biomimetic 3D matrices. Biomater. Sci. 2017, 5, 1858–1867.
Sapudom, J.*; Ullm, F.*; Martin, S.; Kalbitzer, L.; Naab, J.; Möller, S.; Schnabelrauch, M.; Anderegg, U.; Schmidt, S.; Pompe, T. Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. Acta Biomater. 2017, 50, 259–270.

2016


Sapudom, J.; Rubner, S.; Martin, S.; Pompe, T. Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces. Adv. Healthc. Mater. 2016, 5, 1861–1867.

2015


Sapudom, J.; Rubner, S.; Martin, S.; Kurth, T.; Riedel, S.; Mierke, C.T.; Pompe, T. The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks. Biomaterials 2015, 52, 367–375.
Sapudom, J.; Rubner, S.; Martin, S.; Thoenes, S.; Anderegg, U.; Pompe, T. The interplay of fibronectin functionalization and TGF-β1 presence on fibroblast proliferation, differentiation and migration in 3D matrices. Biomater. Sci. 2015, 3, 1291–1301.

2014


Franke, K.; Sapudom, J.; Kalbitzer, L.; Anderegg, U.; Pompe, T. Topologically defined composites of collagen types i and v as in vitro cell culture scaffolds. Acta Biomater. 2014, 10, 2693–2702.

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