Patents

•  J.C.M. Teo, J. Sapudom, B.C. Quartey, A. Garcia-Sabaté, Non-Invasive Tuning of Protein Alignment. (Application Number: PCT/B2024/051112, pending)
•  J.C.M. Teo, J. Sapudom, Improving Stem Cell Differentiation Potency Using Simulated Microgravity. (Provisional Application under 35 USC 111(b), Application number: 63/651,916)

Publications

* equally contributed      # corresponding author

Preprints

• J. Sapudom*, A. Alatoom*, P.S. Tipay, J. Teo, Matrix fibril alignment and density modulate YAP-mediated T-cell immune suppression. (BioArxiv)

2025

• C. Martkamjan, K. Lerdsudkanung, P.S. Tipay, R. Rezgui, J. Teo#, J. Sapudom#, Machine Learning-Based Label-Free Macrophage Phenotyping in Immune-Material Interactions, J Mater Chem B (2025)
• J.K. Wychowaniec, E.I.Bektas, , M. Mürner, J. Sapudom, M. Srejber, M. Airoldi, R. Schmidt, A.J. Vernengo, C.J.C. Edwards-Gayle, P.S. Tipay, ,M. Otyepka, J. Teo, D. Eglin, M. D'Este, Effect of Tyrosine-Containing Self-Assembling β-Sheet Peptides on Macrophage Polarization and Inflammatory Response, , ACS Appl Mater Interfaces (2025)
• B.C. Quartey*, J. Sapudom*, P.S. Tipay, Y. Hunashal, S. Alshehhi, M. Arnoux, T. Cardoso, J. Quilez, F. Piano, J. Teo, Hydrogel-based tumor tissue microarchitecture reshapes dendritic cell metabolic profile and functions, Adv Healthc Mater (2025)
• N. Hallfors, C. Lamprou, S. Luo, S. Alkhatib, J. Sapudom, C. Aubrey, J. Alhammadi, V. Chan, C. Stefanini, J. Teo, L. Hadjileontiadis, A. Pappa, Data-Driven Analysis for the Evaluation of Cortical Mechanics of Non-Adherent Cells, Sci Rep 15 (2025) 9700.
• J. Sapudom*, A. Alatoom*, P.S. Tipay, J.C. Teo, Matrix stiffening from collagen fibril density and alignment modulates YAP-mediated T-cell immune suppression, Biomaterials 315 (2025) 122900
•  J.K. Wychowaniec, E.I. Bektas, A.J. Vernengo, M. Muerner, M. Airoldi, P.S. Tipay, J. Sapudom, J. Teo, D. Eglin, M. D'Este, Effect of molecular weight of tyramine-modified hyaluronan on polarization state of THP-1 and peripheral blood mononuclear cells-derived macrophages, Biomater Adv 169 (2025) 214166.

2024

• J. Sapudom*, P. Riedl*, M. Schricker, K. Kroy, T. Pompe, Physical network regimes of 3D fibrillar collagen networks trigger invasive phenotypes of breast cancer cells, Biomater Adv 163 (2024) 213961. 
• B.C. Quartey, G. Torres, M. ElGindi, A. Alatoom, J. Sapudom, J.C.M. Teo, Tug of war: Understanding the dynamic interplay of tumor biomechanical environment on dendritic cell function, Mechanobiology in Medicine 2(3) (2024) 100068.
• A. Menon, K. Elkhoury, A. Zahraa, J. Sapudom, Z. Rahic, K.C. Gunsalus, J. Teo, N. Gupta, S. Vijayavenkataraman, Digital light processing 3D printing of dual crosslinked meniscal scaffolds with enhanced physical and biological properties, Advanced Composites and Hybrid Materials 8(1) (2024) 92.
• N. Prigyai, T. Bunchuay, A. Ruengsuk, N. Yoshinari, J. Manissorn, P. Pumirat, J. Sapudom, P. Kosiyachinda, P. Thongnuek, Photo-Controlled Reversible Uptake and Release of a Modified Sulfamethoxazole Antibiotic Drug from a Pillar[5]arene Cross-Linked Gelatin Hydrogel, ACS Appl Mater Interfaces  (2024).

2023

• J. Sapudom, S. Karaman, B.C. Quartey, W.K.E. Mohamed, N. Mahtani, A. Garcia‐Sabaté, J. Teo, Collagen Fibril Orientation Instructs Fibroblast Differentiation Via Cell Contractility, Advanced Science. 10 (2023) 2301353. 
• P. Riedl*, J. Sapudom*, C. Clemens, L. Orgus, A. Pröger, J.C.M. Teo, T. Pompe, Phenotype Switching of Breast Cancer Cells upon Matrix Interface Crossing, ACS Appl. Mater. Interfaces. 15 (2023) 24059–24070. 
• B.C. Quartey*, J. Sapudom*, M. ElGindi, A. Alatoom, J. Teo, Matrix-Bound Hyaluronan Molecular Weight as a Regulator of Dendritic Cell Immune Potency, Adv Healthc Mater  (2023) e2303125.
• M. ElGindi, J. Sapudom, A. Garcia Sabate, B.C. Quartey, A. Alatoom, M. Al-Sayegh, R. Li, W. Chen, J. Teo, Effects of an aged tissue niche on the immune potency of dendritic cells using simulated microgravity, Npj Aging. 9 (2023) 14. 
• J. Sapudom*,#, M. Kongsema*, A. Methachittipan, S. Damrongsakkul, S. Kanokpanont, J.C.M. Teo, M. Khongkow, K. Tonsomboon, P. Thongnuek, Degradation products of crosslinked silk fibroin scaffolds modulate the immune response but not cell toxicity, J. Mater. Chem. B. 11 (2023) 3607–3616.
• A. Alatoom, M. ElGindi, J. Sapudom, J.C.M. Teo, The T Cell Journey: A Tour de Force, Adv. Biol. 7 (2023) 2200173. 

2022

• M. ElGindi, J. Sapudom, P. Laws, A. Garcia-Sabaté, M.F. Daqaq, J. Teo, 3D microenvironment attenuates simulated microgravity-mediated changes in T cell transcriptome, Cell. Mol. Life Sci. 79 (2022) 508. 

2021

• Sapudom, J.; Karaman, S.; Mohamed, W.K.E.; Garcia-Sabaté, A.; Quartey, B.C.; Teo, J. 3D in vitro M2 macrophage model to mimic modulation of tissue repair, npj Regenerative Medicine 2021, 6,83 .
• Sapudom, J.*; Elgindi, M.*; Arnoux, M.; Drou, N.; Garcia-Sabaté, A.; Teo, J. Fibroblast Differentiation and Matrix Remodeling Impaired under Simulated Microgravity in 3D Cell Culture Model, Int. J. Mol. Sci. 2021, 22, 11911.
• ElGindi, M.; Sapudom, J.; Ibrahim, I.H.; Al-Sayegh, M.; Chen, W.; Garcia-Sabaté, A.; Teo, J.C.M. May the Force Be with You (Or Not): The Immune System under Microgravity. Cells 2021, 10, 1941.
• Elgindi, M.; Ibrahim I.H..; Sapudom, J.; Garcia-Sabaté, A.; Teo, J.. Engineered Microvessel for Cell Culture in Simulated Microgravity. Int. J. Mol. Sci. 2021, 22, 6331.
• Hallfors, N.; Shanti, A.; Sapudom, J.;  Teo, J.; Petroianu, G.; Lee, S.; Planelles, L.; Stefanini, C. Multi-Compartment Lymph-Node-On-A-Chip Enables Measurement of Immune Cell Motility in Response to Drugs. Bioengineering 2021, 8, 19.

2020

• Menachery, A.*; Sapudom, J.*; Vembadi, A.; Alatoom, A.; Teo, J.; Qasaimeh, M.A. Dielectrophoretic characterization of dendritic cell deformability upon maturation. BioTechniques. 2020, 70, 29-36.
• Bahmad, H.F.; Daouk, R.; Azar, J.; Sapudom, J.; Teo, J.C.M. ; Abou-Kheir, W.; Al-Sayegh, M. Modeling Adipogenesis: Current and Future Perspective. Cells. 2020, 9, 2326. 
• Sapudom, J.#; Müller, C.D.; Nguyen, K.T.; Martin, S.; Anderegg, U.; Pompe, T. Matrix Remodeling and Hyaluronan Production by Myofibroblasts and Cancer-Associated Fibroblasts in 3D Collagen Matrices. Gels 2020, 6, 33.
• Garcia-Sabaté, A.; Mohamed, W.K.E.; Sapudom, J.; Alatoom, A.; Al Safadi, L.; Teo, J.C.M. Biomimetic 3D models for investigating the role of monocytes and macrophages in atherosclerosis. Bioengineering. 2020, 7, 113.
• Sapudom, J.; Alatoom, A.; Mohamed, W.K.E.; Garcia-Sabaté, A.; McBain, I.; Nasser, R.; Teo, J.C.M. Dendritic cell immune potency on 2D and in 3D collagen matrices. Biomater. Sci. 2020, 8,  5106-5120.
• Shanti, A.; Samara, B.; Abdullah, A.; Hallfors, N.; Accoto, D.; Sapudom, J.; Alatoom, A.; Teo, J.; Danti, S.; Stefanini, C. Multi-Compartment 3D-Cultured Organ-on-a-Chip: Towards a Biomimetic Lymph Node for Drug Development. Pharmaceutics 2020, 12, 464.
• Seo, B.R.; Chen, X.; Song, Y.H.; Ling, L.; Choi, S.; Gonzalez, J.; Sapudom, J.; Wang, K.; Andresen Eguiluz, R.C.; Gourdon, D.; Shenoy V.B.; Fischbach C. Collagen Microarchitecture Mechanically Controls Myofibroblast Differentiation. Proc. Natl. Acad. Sci. 2020, 201919394.
• Sapudom, J.*; Mohamed, W.K.E.*; Garcia-Sabaté, A.; Alatoom, A.; Karaman, S.; Mahtani, N.; Teo, J.C.M. Collagen fibril density modulates macrophage activation and cellular functions during tissue repair. Bioengineering 2020, 7, 33.
• Sapudom, J.*; Nguyen, K.T.*; Martin, S.; Wippold, T.; Möller, S.; Schnabelrauch, M.; Anderegg, U.; Pompe, T. Biomimetic tissue models reveal the role of hyaluronan in melanoma proliferation and invasion. Biomater. Sci. 2020, 8, 1405–1417.
• Alatoom, A.*; Sapudom, J.*; Soni, P.; Mohamed, W.K.E.; Garcia‐Sabaté, A.; Teo, J. Artificial Biosystem for Modulation of Interactions between Antigen‐Presenting Cells and T Cells. Adv. Biosyst. 2020, 2000039

2019

• Sapudom, J.; Kalbitzer, L.; Wu, X.; Martin, S.; Kroy, K.; Pompe, T. Fibril bending stiffness of 3D collagen matrices instructs spreading and clustering of invasive and non-invasive breast cancer cells. Biomaterials 2019, 193, 47–57.
• Witzel, I.I.; Nasser, R.; Garcia-Sabaté, A.; Sapudom, J.; Ma, C.; Chen, W.; Teo, J.C.M. Deconstructing Immune Microenvironments of Lymphoid Tissues for Reverse Engineering. Adv. Healthc. Mater. 2019, 8, 1801126.

2018

• Sapudom, J.; Pompe, T. Biomimetic tumor microenvironments based on collagen matrices. Biomater. Sci. 2018, 6, 2009–2024.
• Kräter, M.*; Sapudom, J.*; Bilz, N.; Pompe, T.; Guck, J.; Claus, C. Alterations in Cell Mechanics by Actin Cytoskeletal Changes Correlate with Strain-Specific Rubella Virus Phenotypes for Cell Migration and Induction of Apoptosis. Cells 2018, 7, 136.

2017

• Sapudom, J.*; Waschke, J.*; Franke, K.; Hlawitschka, M.; Pompe, T. Quantitative label-free single cell tracking in 3D biomimetic matrices. Sci. Rep. 2017, 7, 14135.
• Ansorge, M.; Sapudom, J.; Chkolnikov, M.; Wilde, M.; Anderegg, U.; Möller, S.; Schnabelrauch, M.; Pompe, T. Mimicking Paracrine TGFβ1 Signals during Myofibroblast Differentiation in 3D Collagen Networks. Sci. Rep. 2017, 7, 5664.
• Sapudom, J.; Wu, X.; Chkolnikov, M.; Ansorge, M.; Anderegg, U.; Pompe, T. Fibroblast fate regulation by time dependent TGF-β1 and IL-10 stimulation in biomimetic 3D matrices. Biomater. Sci. 2017, 5, 1858–1867.
• Sapudom, J.*; Ullm, F.*; Martin, S.; Kalbitzer, L.; Naab, J.; Möller, S.; Schnabelrauch, M.; Anderegg, U.; Schmidt, S.; Pompe, T. Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. Acta Biomater. 2017, 50, 259–270.

2016

• Sapudom, J.; Rubner, S.; Martin, S.; Pompe, T. Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces. Adv. Healthc. Mater. 2016, 5, 1861–1867.

2015

• Sapudom, J.; Rubner, S.; Martin, S.; Kurth, T.; Riedel, S.; Mierke, C.T.; Pompe, T. The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks. Biomaterials 2015, 52, 367–375.
• Sapudom, J.; Rubner, S.; Martin, S.; Thoenes, S.; Anderegg, U.; Pompe, T. The interplay of fibronectin functionalization and TGF-β1 presence on fibroblast proliferation, differentiation and migration in 3D matrices. Biomater. Sci. 2015, 3, 1291–1301.

2014

• Franke, K.; Sapudom, J.; Kalbitzer, L.; Anderegg, U.; Pompe, T. Topologically defined composites of collagen types i and v as in vitro cell culture scaffolds. Acta Biomater. 2014, 10, 2693–2702.