Research Interests
To understand the role of blood flow in the development and progression of cardiovascular disease conditions (Atherosclerosis, Aneurysms) and simplifying controlled drug release through complex tumour vasculature by addressing Interstitial Fluid Pressure(IFP) challenges and its metastasis, recurrence using Biological heat transport principles. The ultimate goal is to improve treatment efficacy by designing novel medical devices that helps to plan, develop, and optimize protocols in clinical hyperthermia, hypothermia thereby improve the state of the cardiovascular and cancer healthcare and increasing survival prognosis of patients.
Applied Cardiovascular Biomechanics, Image Based Computational Models, Biological Heat Transport, Organ-Specific Tissue Cooling, Nanoparticles in Cancer Treatment.
Doctorate in Mechanical Engineering
[January, 2018-August, 2022]
GPA: 3.62/4.0 [U.S. Equivalent]
PhD Research Scholar
Bioheat Transfer Laboratory,
University of Maryland, Baltimore County, MD-21250, USA.
Interdisciplinary Research Project:
To evaluate the effects of whole body and local mild hyperthermia on the deposition of gold nanoparticles and see deposition after micro-CT scan.
To measure tumour blood perfusion rates, tumour temperatures, tumour interstitial fluid pressure.
To develop a theoretical model to quantify nanoparticle transport across tumour capillaries as well as nanoparticle diffusion and advection in the tumour interstitial space.
Masters in Engineering in Thermal Engineering with Distinction
[July, 2014-September, 2016]
*GPA (Grade Point Average as Grading Criterion): 3.51/4.0 [U.S. Equivalent]
% (Percentage as Grading Criterion): 87.90/100.0 [India Equivalent]
CGPA (Cumulative Grade Point Average as Grading Criterion): 8.79/10.0 [India Equivalent]
Thapar Institute of Engineering and Technology University,
Patiala, Punjab, India.
*indicates U.S. Equivalent Grades as evaluated through WES (World Education Services)
Bachelors in Technology in Mechanical Engineering with Distinction
[July, 2008-June, 2012]
*GPA (Grade Point Average as Grading Criterion): 3.77/4.0 [U.S. Equivalent]
% (Percentage as Grading Criterion): 80.74/100.0 [India Equivalent]
Guru Nanak Dev Engineering College,
Ludhiana, Punjab, India.
*indicates U.S. Equivalent Grades as evaluated through WES (World Education Services)
Skills
Materialise MIMICS-19.O (Image Processing)
Materialise 3-matic-11.0 (Image Reconstruction)
Sim4Life-4.4
COMSOL-MULTIPHYSICS 5.4 (Finite Element Analysis)
Data analysis through SAS
Solidworks
MATLAB
Working knowledge of complete Microsoft Office suite (including Word, Excel, and Powerpoint)
Good technical writing and presentation skills
Groups & Associations
Member of the Society of Thermal Medicine, (STM 2020), (STM 2022).
Member of the American Society of Mechanical Engineers (ASME 2020-2021).
Member of 'Indian Society of Heating, Refrigeration and Air-Conditioning Engineers'(ISHRAE).
Member of the 'Institution of Engineers (India)'-Registered No. 140-11-009.
Research Publications
Peer-Reviewed Journal Articles
M.Singh, Q.Gu, R.Ma, L.Zhu, “Heating Protocol Design Affected by Nanoparticle Re-distribution and Thermal Damage Model in Magnetic Nanoparticle Hyperthermia for Cancer Treatment,” in the ASME J. Heat Transfer, 2020. https://doi.org/10.1115/1.4046967
M.Singh, S.Soni, T.Singh, “Pre-operative Assessment of Ablation Margins for Variable Blood Perfusion Metrics in a Magnetic Resonance Imaging Based Complex Breast Tumour Anatomy: Simulation Paradigms in Thermal Therapies,” in the Computer Methods and Programs in Biomedicine, 2021. https://doi.org/10.1016/j.cmpb.2020.105781
M.Singh, R.Ma, L.Zhu, “Theoretical Evaluation of Enhanced Nanoparticle Delivery to PC3 Tumors due to Increased Hydraulic Conductivity or Recovered Lymphatic Function after Mild Whole Body Hyperthermia” in the Medical Biological Engineering and Computing, 2021. https://doi.org/10.1007/s11517-020-02308-4
M.Singh, R.Ma, L.Zhu, "Quantitative Evaluation of Effects of Coupled Temperature Elevation, Thermal Damage, and Enlarged Porosity on Nanoparticle Migration in Tumors during Magnetic Nanoparticle Hyperthermia" in the International Communications in Heat and Mass Transfer, 2021. https://doi.org/10.1016/j.icheatmasstransfer.2021.105393
M.Singh, "Incorporating Vascular-stasis Based Blood Perfusion to evaluate the Thermal Signatures of Cell-death using Modified Arrhenius Equation with Regeneration of Living Tissues during Nanoparticle-assisted Thermal Therapy" in the International Communications in Heat and Mass Transfer, 2022. https://doi.org/10.1016/j.icheatmasstransfer.2022.106046
M.Singh, "Biological Heat and Mass Transport Mechanisms Behind Nanoparticles Migration Revealed under MicroCT Image Guidance" in the International Journal of Thermal Sciences, 2023. https://doi.org/10.1016/j.ijthermalsci.2022.107996
M.Singh, "Modified Pennes Bioheat Equation with Heterogeneous Blood Perfusion: A newer Perspective" in the International Journal of Heat and Mass Transfer, 2024. https://doi.org/10.1016/j.ijheatmasstransfer.2023.124698
M. Singh, "A 3-D whole-body human thermoregulatory model to simulate cold-induced vasodilation in the hands and feet" in Computers in Biology and Medicine, 2024.
Peer-Reviewed Conference Proceedings
M.Singh, Q.Gu, R.Ma, and L.Zhu, “Temperature distribution and thermal dosage affected by nanoparticle distribution in tumours during magnetic nanoparticle hyperthermia” at Proceedings of the 6th ASME International Conference on Micro/Nanoscale Heat and Mass Transfer, MNHMT 2019-4233 was held on July 9-10, 2019, Dalian, China. https://doi.org/10.1115/MNHMT2019-4233
M.Singh, R.Ma, L.Zhu, “Investigation of Enhanced Nanoparticle Delivery to PC3 Tumors due to Recovered Lymphatic Function after Mild Whole Body Hyperthermia – A Theoretical Simulation” at 15th International Conference on Heat Transfer, Fluid Mechanics, and Thermodynamics (HEFAT-2021), will be held in July, 2021 in Amsterdam, Netherlands.
Conference Podium Presentation
M.Singh, Q.Gu, R.Ma, and L.Zhu, “Heating Protocol design affected by thermal damage model in magnetic nanoparticle hyperthermia for cancer treatment” at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2019 was held on June 25-28, 2019 at Seven Springs, PA, USA. (*Paper No. 005)
M.Singh, "Incorporating vascular stasis based perfusion to predict the thermal signatures of cell death using modified Arrhenius equation with regeneration of living tissues" at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2022 was held on June 20-23rd, 2022 at Cambridge, MD, USA.
Conference Abstracts (Poster Presentation)
T.Diorio, N.Bouhrira, M.Singh, and T.L.Merrill, “Computational modeling of the left coronary artery during targeted therapeutic hypothermia” at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2017 was held on 21-24th June, 2017 at Tucson, USA.
M.Singh, R.Ma, and L.Zhu, “Theoretical evaluation of temperature elevation, thermal damage,transport porosity enhancement, and magnetic nanoparticle migration in tumors during local heating” at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2019 was held on June 25-28th, 2019 at Seven Springs, PA, USA. (*Paper No. 158)
M.M.Zaw, M.Singh, R.Ma, and L.Zhu, “Safe duration of a person soaking inside a hot tub: Theoretical prediction of temperature elevations in human bodies using a whole body heat transfer model” at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2019 was held on June 25-28th, 2019 at Seven Springs, PA, USA. (*Paper No. 153)
M.Singh, Q.Gu, R.Ma, and L.Zhu, “Heating Protocol design affected by thermal damage model in magnetic nanoparticle hyperthermia for cancer treatment” at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2019 was held on June 25-28, 2019 at Seven Springs, PA, USA. (*Paper No. 005)
M.Singh, R.Ma, and L.Zhu, “Theoretical simulation of nanoparticle migration in PC3 tumors coupled with temperature elevations and thermal damage assessment during magnetic nanoparticle hyperthermia” at Biomedical Engineering Society, BMES-2019 was held on October 16-19, 2019 at Philadelphia, PA, USA.
M.Singh, “Perfusion mediated assessment of ablation margins in an irregular patient-specific tumour anatomy” at 16th Annual USM PROMISE AGEP Research Symposium & Professional Development Conference-2020 was held on February 21st, 2020 at University of Maryland School of Medicine, MD, USA.
M.Singh, R.Ma, L.Zhu, “Enhanced nanoparticle deposition in PC3 tumors by mild whole body hyperthermia – A theoretical simulation” at Summer Biomechanics, Bioengineering, and Biotransport Virtual Conference, SB3C-2020 was held on June 17-20th, 2020 at Vail, CO, USA. (*Paper No. 062)
M.Singh, H.Flores, R.Ma, L.Zhu, “Extraction of baseline blood perfusion rates in mouse body and implanted PC3 tumor using infrared images and theoretical simulation” at Summer Biomechanics, Bioengineering, and Biotransport Virtual Conference, SB3C-2020 was held on June 17-20th, 2020 at Vail, CO, USA. (*Paper No. 347)
M.Singh, B.Turnbaugh, R.Ma, L.Zhu, “Managing cooling penetration and minimizing systemic hypothermia after surgery using a cooling pad – Whole body heat transfer simulation” at Summer Biomechanics, Bioengineering, and Biotransport Virtual Conference, SB3C-2020 was held on June 17-20th, 2020 at Vail, CO, USA. (*Paper No. 509)
M.Singh, “Heterogeneous blood perfusion mapping in cancerous lesions” at Summer Biomechanics, Bioengineering, and Biotransport Virtual Conference, SB3C-2021 was held on June 14-18th, 2021, USA. (*Paper No. 017)
M.Singh, M.Dalal, G.S.Sodhi, “Estimation of clinical size of breast tumour lesions using contrast enhanced magnetic resonance imaging: Delineation of tumour boundaries” at Summer Biomechanics, Bioengineering, and Biotransport Virtual Conference, SB3C-2021 was held on June 14-18th, 2021, USA. (*Paper No. 355)
M.Singh, "Influence of vascular stasis based blood perfusion on magnetic nanoparticles migration using modified thermal damage model: An illustration of thermal By-stander effect" at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2022 will be held on June 20-23rd, 2022 at Cambridge, MD, USA.
M.Singh, "Incorporating vascular stasis based perfusion to predict the thermal signatures of cell death using modified Arrhenius equation with regeneration of living tissues" at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2022 will be held on June 20-23rd, 2022 at Cambridge, MD, USA.
M.Singh, "Performance of Skin Cooling Device in Cooling Penetration in Tissue-Experiments and Simulations" at Summer Biomechanics, Bioengineering, and Biotransport Conference, SB3C-2022 will be held on June 20-23rd, 2022 at Cambridge, MD, USA.
M.Singh, "Transport Physics Behind Nanoparticles Migration and Biological Tissue Regeneration Mechanisms During Burn Injury Revealed" at Society for Thermal Medicine, STM-2022 was held virtually on May 01-4th, 2022, Abstract #75.
A.Caporale, J. Lombardo, M.Singh, L.Zhu,"Development of an Empirical Correlation to Predict Cooling Penetration into Tissue for Practical Use" at the Biomedical Engineering Society, BMES-2022 Annual Meeting was held on October 12-15th, 2022 at San Antonio, TX, USA.
E.Quinn, M.Singh, L.Zhu, "Laser Photothermal Therapy Simulation for Designing Breast Tumor Treatment Protocol" at CMBBE 2023: 18th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering was held on May 03-05th, 2023 at Paris, France.
M.Singh, "Modified Pennes Bioheat Equation with Heterogeneous Blood Perfusion" at AMMCS-2023: The VIth Interdisciplinary International Conference on Applied Mathematics, Modeling and Computational Science: Special Symposium “Coupled Complex Systems and Multiple Scales, Their Modelling, and Applications” will be held on August 14-18th, 2023 at Waterloo, Ontario, Canada, Abstract #327.
M.Singh, "Heterogeneous Blood Perfusion Redistribution for Magnetic Nanoparticle Assisted Thermal Ablation: A Coupled Complex System Under Imaging Guidance" at AMMCS-2023: The VIth Interdisciplinary International Conference on Applied Mathematics, Modeling and Computational Science: Special Symposium “Coupled Complex Systems and Multiple Scales, Their Modelling, and Applications” will be held on August 14-18th, 2023 at Waterloo, Ontario, Canada, Abstract #332.
Invited Book Chapters:
A. Bhowmik, M.Singh, R. Repaka, "Bioheat Transfer Models: Theory and Applications in Bioengineering" in Biofluid Dynamics of Human Body System, 2nd Ed.. (2023)
A. Bhowmik, M.Singh, R. Singh, "Medical Imaging of Human Body Fluids: Principle and Diagnostics" in Biofluid Dynamics of Human Body System, 2nd Ed.. (2023)
E.Quinn, M.Singh, L.Zhu, "Treatment Protocol Design for Breast Cancer Using Laser Photothermal Therapy Simulation" in Springer Book Lecture Notes in Computational Vision and Biomechanics. (2023)
Manuscripts under Review
M.Singh, "MRI-Imaging Assisted Numerical Investigation of Transport Porosity and Diffusivity Enhancement: Modelling Material Heterogeneties, Thermal Diffusion and Possible Magnetic Nanoparticle Migration in Tumors During Localised Heating using Voxel-based Assessment" in review with the J. Medical Image Analysis.
M. Singh, "Infrared Imaging Assisted Extraction of Blood Perfusion in PC3 Tumours" in review with the J. Biomedical Engineering Advances.
M. Singh, "Influence of Infusion Rate on Possible Nanoparticle Redistribution During Heating" in review with the J. Nanomedicine: Nanotechnology, Biology and Medicine.
M. Singh, "Numerical Investigation of Spatio-temporal Perfusion Dynamics with Heterogeneous Thermophysical Parameters Variation in an MRI-image extracted irregular breast-tumour surrounded with multi-layer breast density compositions during nanoparticle assisted thermal therapy" in review with the J. International Journal of Heat and Mass Transfer.
Reviewer:
Technology in Cancer Research and Treatment
Frontiers in Medical Technology
Computer Methods and Programs in Biomedicine
Applied Sciences
Electronics
Healthcare
Journal of Clinical Medicine
International Journal of Molecular Sciences
Cancers
International Journal of Environmental Research and Public Health
Photonics
Summer Biomechanics, Bioengineering and Biotransport Conference -2023 (MS Student Competition) (SB3C 2023)
Summer Biomechanics, Bioengineering and Biotransport Conference -2022 (ASME-BED Student Paper Competition) (SB3C 2022)
USM LSAMP Research Symposium
Diagnostics
Entropy
Sensors
Mathematics
Frontiers in Oncology
Summer Biomechanics, Bioengineering and Biotransport Conference -2023 (BS Student Competition) (SB3C 2023)
Life
Brain Sciences
Micromachines
Computers in Biology and Medicine
Case Studies in Thermal Engineering
PLoS One
Heat and Mass Transfer
Thermal Science and Engineering Progress
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy
Bioengineering
Journal of Mechanics in Medicine and Biology
Taylor and Francis Group
Senior Editor of Book, CRC Press (Taylor & Francis Group):
Senior Editor of Book titled, "Advanced Manufacturing Technologies in Biomedical Science: Practical Applications, Case Studies, and Future Trends," Taylor and Francis Group
Guest Editor:
Appointed as Guest Editor in Special Issue of Bioengineering (ISSN 2306-5354) "Recent Advances in the Application of Mathematical and Computational Models in Biomedical Science and Engineering 2.0"
Appointed as Guest Associate Editor in Special Issue of Frontiers in Thermal Engineering - Section: Heat Transfer Mechanisms and Applications "Bio-thermal Medical Devices, Methods, and Models: New Developments and Advances"
Academic Editor:
Appointed as Academic Editor in the journal PLOS ONE
Review Editor:
Frontiers in Thermal Engineering (Micro- and Nano-Scale Heat Transfer)
ASME Journal of Thermal Science and Engineering Applications
ASME Journal of Engineering and Science in Medical Diagnostics and Therapy
Topic Coordinator:
Topic Coordinator for Special Issue of Frontiers in Thermal Engineering: Heat Transfer Mechanisms and Applications.
Computational Modeling of Various Procedures in Thermal Therapy of Human Tumors.
Topical Advisory Panel Member:
Research Impact Worldwide (cited >200 times across 40 countries):
North America: United States, Canada
Central America: Mexico
South America: Brazil, Peru
Asia: India, China, Iran, Thailand, Japan, Vietnam, South Korea, Singapore, Malaysia, Bangladesh
Europe: Romania, Italy, Malta, Spain, Ireland, Netherlands, Germany, Serbia, Switzerland, Hungary, Russia, Belgium, Greece, France, Austria, United Kingdom, Portugal, Czech Republic, Cyprus
Oceania: Australia
Middle East: Türkiye, Syria, Lebanon, Saudi Arabia, United Arab Emirates