Bryce W. Collingwood, Amruta Bhalkar, and Carol M. Manhart. The mismatch repair factor Mlh1-Pms1 uses ATP to compact and remodel DNA, submitted, BioRxiv: https://www.biorxiv.org/content/10.1101/2025.01.16.633381v1
Jonathan M. Piscitelli, Scott J. Witte, Yasmine Sakinejad and Carol M. Manhart. Mlh1-Pms1 ATPase activity is regulated distinctly by self-generated nicks and strand discrimination signals in mismatch repair, Nucleic Acids Research, 2024, 53 (3): gkae1253.
Bryce W. Collingwood, Scott J. Witte, and Carol M. Manhart. Action-at-a-distance in DNA mismatch repair: mechanistic insights and models for how DNA and repair proteins facilitate long-range communication, Biomolecules (Special Issue), invited review article, 2024, 14 (11): 1442.
Aloran Mazumder, J. Tyler DeWitt, E. Oropeza, N. Punturi, D. Lozano, M. Raghunathan, Jonathan M. Piscitelli, E. Sajjadi, E. Guerini-Rocco, K. Venetis, M. Ivanova, E. Mane, N. Fusco, M. N. Bainbridge, Carol M. Manhart, Svasti Haricharan. Aberrant cytoplasmic localization of MLH1 characterizes a sub-clonal breast cancer cell population that seeds recurrence, submitted. bioRxiv 2024.02.27.582389; doi: https://doi.org/10.1101/2024.02.27.582389.
Michael Gioia, Lisette Payero, Gianno Pannafinno, Jun Jie Chen, Sagar Salim, Ghanim Fajish V, Amamah F. Farnaz, Sherikat Momoh, Michelle Scotland, Vandana Raghavan, Carol M. Manhart, Akira Shinohara, K.T. Nishant, and Eric Alani. Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis, PLOS Biology, 2023, 21 (4): e3002085.
Scott J. Witte, Isabella M. Rosa, Bryce W. Collingwood, Jonathan M. Piscitelli, and Carol M. Manhart. The mismatch repair endonuclease MutL𝝰 tethers duplex regions of DNA together and relieves DNA torsional tension, Nucleic Acids Research, 2023, 51 (6): 2725-2739.
Carol M. Manhart. DNA Mismatch Repair in Mammals, Encyclopedia of Biological Chemistry, 3rd edition, 2021, invited chapter, ISBN: 9780128096338, DOI: 10.1016/B978-0-12-819460- 7.00234-6.
Yoori Kim*, Christopher M. Furman*, Carol M. Manhart, Eric Alani, Ilya J. Finkelstein. Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutL𝝰 mismatch repair complex, Nucleic Acids Research, 2018, 47 (4): 1823-1835. [*contributed equally to this work]
Carol M. Manhart, Xiaodan Ni, Martin A. White, Joaquin Ortega, Jennifer Surtees, and Eric Alani. The mismatch repair and meiotic recombination endonuclease Mlh1-Mlh3 is activated by polymer formation and can cleave DNA substrates in trans, PLoS Biology, 2017, 15 (4): e2001164.
Carol M. Manhart and Eric Alani. Roles for mismatch repair family proteins in promoting meiotic crossing over, DNA Repair (Special Issue), invited review article, 2016, 38: 84-93.
Carol M. Manhart and Charles S. McHenry. Identification of subunit binding positions on a model fork and displacements that occur during sequential assembly of the Escherichia coli primosome, Journal of Biological Chemistry, 2015, 290 (17): 10828-10839.
Maria V. Rogacheva*, Carol M. Manhart*, Cheng Chen, Alba Guarné, Jennifer Surtees, and Eric Alani. Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease, Journal of Biological Chemistry, 2014, 289 (9): 5664-5673. [*contributed equally to this work]
Paul R. Dohrmann, Carol M. Manhart, Christopher D. Downey, and Charles S. McHenry. The rate of polymerase release upon filling the gap between Okazaki fragments is inadequate to support cycling during lagging strand synthesis, Journal of Molecular Biology, 2011, 414 (1): 15-27.