Manhart Lab

We aim to understand DNA repair using biochemistry, biophysics, chemistry, molecular biology, and genetics. Our work contributes to models of human disease, particularly cancers associated with Lynch syndrome (colorectal, endometrial, and others) and neurological diseases associated with trinucleotide repeat instability. Our work provides a foundation for understanding fundamental cellular pathways and developing new diagnostic tools, identifying new therapeutic targets, and developing technology to improve nucleases used in clinical and biotechnological applications.