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Project 1: Multi-Omic Diagnostic Framework for Urological Cancer: Integrated Urinary Transcriptomics, Metabolomics, and Lipidomics for Prostate and Other Urological Cancer Screening and Therapy Development.
Preliminary Research: Urine RNA and metabolites | Metabolites for tracking prostate cancer progression | Metabolites for prostate health diagnosis | Metabolites for rapid prostate cancer detection | Machine learning for non-invasive metabolic biomarkers for prostate cancer.
Project 2: Discovery of smart mechanism of actions of imipridone alone or in combination through multi-modal cell death mechanims in glioma and uveal melanoma.
Preliminary Research: Imipridone inhibits PDX tumor of UM | Imipridone inhibits liver metastsis of UM | Multi-organ multiomics to test drug efficacy | Single sample multiomics for drug toxicity.
Project 3: Biology-informed lipid biochemistry landscape in uncovering novel molecular mechanisms and therapeutics for cancer, malnutrition, obesity, atherosclerosis, cardiovascular disease, diabetic kidney disease (DKD), and inflammatory disease.
Preliminary research: De novo lipogenesis and cancer | Cell cycle arrest-Lipid droplets-Ferroptosis | Colorectal cancer-Inflammatroy neuropathy-Lipidome | SPOP-CHD1-ACSL4 lipidome-Prostate cancer | CHD1-SPOP-SREBP2 cholesterol-Prostate cancer | GPR1-CMKLR1-RARRES2-ccRCC-Lipidome |Dimeric mutant p53 and lipidome | Obesity-ccRCC-adipokine-monoclonal antibody.
Project 4: Understanding Child Malnutrition Through Metabolomics and Lipidomics. Child malnutrition affects roughly one in four children under five worldwide, contributing to stunting, wasting, and overweight growth patterns that carry lifelong consequences — from poorer health outcomes to reduced economic opportunity in adulthood. Despite decades of effort, therapeutic interventions remain limited, and existing therapeutic foods often fail to deliver lasting results for affected children.
Our work explores a promising but underused lens on this problem: the body's own metabolites and lipids. These molecules are increasingly recognized as early indicators of child health, yet their role in the biology of malnutrition remains poorly understood.
This project uses mass spectrometry–based metabolomics and lipidomics to map how metabolic and lipid profiles shift in malnourished children. By identifying these biological signatures, we aim to uncover the underlying mechanisms driving malnutrition and its complications — laying the groundwork for more effective, targeted interventions.
Our goal is to translate these insights into real therapeutic strategies, moving beyond current approaches toward solutions grounded in the biology of the children they're meant to help.
Preliminary research: Decoding multiomics approaches in malnutrition | Lipidomics in human cancer and nutrition | Multiomics-MASH-Atherosclerosis | Multi-organ multiomics in drug toxicity
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