Research

Antibacterial agent discovery

Our research aims to study bacterial transcription as an essential biological process, but underutilized target for antibiotic discovery. We intent to study the function and structural information of proteins involved in transcription which are essential for bacterial viability. The inhibition of these crucial protein-protein interactions is expected to generate new classes of antibiotic drug candidates suppressing bacterial resistance to antibiotics.

Antiviral agent discovery

We aim to develop new antiviral agents against influenza virus. One of the approaches is of probing the 150-cavity which is nascent to the activity site of neuraminidase (NA) . Based on the crystal structure of NA and combination principle of drug design, we have designed, synthesized and evaluated N-substituted oseltamivir derivatives。

Organic methodology development

Natural products, bioactive compounds and drugs contain some common structures or scaffolds. We are interested in developing useful synthetic methods for preparation of these structures.

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