The project is based on the very unique and perfectly matching experience and on the most recent findings of the three collaborating groups, which have the same objective, complementary skills and have made significant discoveries in the field of the chemistry of antimicrobial compounds:

• the Polish group has shown how metals can enhance the antimicrobial mode of action of AMPs by modifying their local charge, structure and/or morphology;

• the Swiss PI is an expert in antimicrobial rhenium complexes, and

• the Romanian group can make the antimicrobial micro/nanocarriers for the combined rhenium-AMP complexes.

Specific Objectives

• Develop antimicrobial peptides (AMPs) with improved stability

• Investigate the effect of metal complexes (e.g. rhenium) on antimicrobial activity

• Design and produce micro/nanocarriers for delivering rhenium-AMP complexes

• Study the synergistic effects between micro/nanocariers and rhenium-AMP complexes

• Evaluate the efficiency of these systems against resistant microorganisms

Expected Impact

• New solutions to fight antimicrobial resistance

• Improved efficiency of antimicrobial treatments

• Strengthening international scientific collaboration

This research is carried out and financed within the framework of the Second Swiss Contribution – MAPS (project No. IZ11Z0_230668) and co-financed by Romania under project code F-RO-CH-2024-0081.