Asymmetric Synthesis 

& 

Catalysis Laboratory

Some of our recent efforts in developing asymmetric organocatalytic strategies are represented below

1. Design of 2-(E)-benzylidine-3-pyrrolidinyl acraldehyde as a potential synthon for asymmetric [4+2]-annulation reactions

Recently MSP research group focussed on developing a robust and sustainable approach for constructing functionally rich optically pure heterocyclic frameworks via [4+2]-addition of in situ generated trienamine from a specially designed 2-(E)-benzylidine-3-pyrrolidinyl acraldehyde as a synthon.

2. Enantioselective synthesis of octahydrofuranoindole core of aspidosperma alkaloids via Diels Alder/reduction- /fluoroetherification reaction sequence

MSP research group very recently successfully devised a method for the synthesis of octahydrofuranoindole core of aspidosperma alkaloids via Diels- Alder/reduction-/fluoroetherification reactions sequence.

3. Employment of N-2,2,2-trifluoroethyl isatinketimines as a potential synthon for asymmetric [3+2]-annulation reactions

The MSP research group is also interested in other aminocatalytic cascade reactions by employing ketimines as a potential synthon for constructing biologically potential spiroheterocycles. MSP group reported the first employment of N-2,2,2-trifluoroethyl isatinketimines as a 1,2-dipolarophile in contrast to the literature.