Publications

Ocampo-Ruiz AL, Dena-Beltrán JL, Dimas-Rufino MA, Castillo X, Vazquez-Carrillo DI, Silos-Guajardo A, Ruiz-Herrera X, Garay E, Martínez de la Escalera G, Clapp C, Arellano RO*, Cisneros-Mejorado AJ*, Macotela Y*. Prolactin Receptor Deficiency Promotes Hypomyelination in White Matter Tracts During Postnatal Central Nervous System Maturation in Mice. Glia. 2025 Sep 3. doi: 10.1002/glia.70081. Online ahead of print. FI: 5.1, Q1

Dena-Beltrán JL, Ocampo-Ruiz AL, Vázquez-Carrillo DI, de Los Ríos EA, Ruiz-Herrera X, Valle-Pacheco M, Robles-Torres SI, Martínez de la Escalera G, Clapp C, Macotela Y. Prolactin maintains the neonatal phenotype of enterocytes during lactation in newborn mice. Am J Physiol Cell Physiol. 2025 Jul 1;329(1):C17-C30. doi: 10.1152/ajpcell.00981.2024. IF 5.0, Q1. Highlighted as APSselect article (July).

Vázquez Carrillo DI, Ocampo-Ruiz AL, Báez-Meza A, Ramírez-Hernández G, Adán-Castro E, García Rodrigo JF, Dena-Beltrán JL, de Los Ríos EA, Sánchez-Martínez MK, Ortiz MG, Martínez de la Escalera G, Clapp C, Macotela Y. Dopamine D2 receptor antagonist counteracts hyperglycemia and insulin resistance in diet-induced obese male mice. PLoS One, 2024 Apr 18;19(4):e0301496. FI: 3.75, Q1

Ferreira SRG*, Macotela Y*, Velloso L, Mori MA. Determinants of Obesity in Latin America. Nature Metabolism. 2024, Mar 4. doi: 10.1038/s42255-024-00977-1. *Equal contribution, FI: 20.8, Q1

Luzardo-Ocampo I, Ocampo-Ruiz AL, Dena-Beltrán JL, Martínez de la Escalera G, Clapp C, Macotela Y. The Diversity of Gut Microbiota at Weaning Is Altered in Prolactin Receptor-Null Mice. Nutrients. 2023, Aug 4;15(15):3447. doi: 10.3390/nu15153447. FI: 5.9, Q1 

Ruiz-Herrera X, Luzardo-Ocampo I, Martínez de la Escalera G, Clapp C, Macotela Y. Differentiated Mouse Adipocytes in Primary Culture: A Model of Insulin Resistance. J Vis Exp. 2023, Feb 17:(192). doi: 10.3791/63979. FI: 1.2, Q2

Luzardo-Ocampo I, Dena-Beltrán JL, Ruiz-Herrera X, Ocampo-Ruiz AL, Martínez de la Escalera G, Clapp C, MacotelaY. Obesity-derived alterations in the lactating mammary gland: Focus on prolactin. Molecular and Cellular Endocrinology. 2022, Oct28. doi: 10.1016/j.mce.2022.111810. FI: 4.1, Q2

Macotela Y*, Ruiz-Herrera X, Vázquez-Carrillo DI, Ramírez-Hernandez G, Martínez de la Escalera G, Clapp C. The beneficial metabolic actions of prolactin. Front Endocrinol (Lausanne). 2022 Sep 23;13:1001703. *Corresponding author. FI: 5.6, Q1

Ramirez-Hernandez G, Adan-Castro E, Diaz-Lezama N, Ruiz-Herrera X, Martinez de la Escalera G, Macotela Y*, Clapp C*. Global Deletion of the Prolactin Receptor Aggravates Streptozotocin-Induced Diabetes in Mice. Front Endocrinol (Lausanne). 2021 Mar 5;12:619696. *Corresponding authors. FI: 5.6, Q1

Macotela, Y*, Triebel, J, Clapp, C., Time for a New Perspective on Prolactin in Metabolism, Trends Endocrinol Metab. 2020 Apr;31(4):276-286. *Corresponding author. FI: 12.0, Q1

Ponce AJ, Galván-Salas T, Lerma-Alvarado RM, Ruiz-Herrera X, Hernández-Cortés T, Valencia-Jiménez R, Cárdenas-Rodríguez LE, Martínez de la Escalera G, Clapp C, Macotela Y.  Low prolactin levels are associated with visceral adipocyte hypertrophy and insulin resistance in humans. Endocrine. 2020 Feb;67(2):331-343. FI: 3.2, Q2

De los Rios, EA., Ruiz-Herrera X, Tinoco-Pantoja V, López-Barrera F, Martínez de la Escalera G, Clapp C, Macotela Y. Impaired prolactin actions mediate altered offspring metabolism induced by maternal high fat feeding during lactation. The FASEB Journal 2018, 32(6):3457-3470. FI: 5.8, Q1

Ruiz-Herrera X, De los Rios AE, Díaz JM, Martínez de la Escalera L, López-Barrera F, Lemini M, Lerma R, Martínez de la Escalera G, Clapp C, Macotela Y. Prolactin promotes insulin sensitivity and adipose tissue fitness in obese males. Endocrinology 2017:158:56-68. **F1000 Recommended: Special Significance http://f1000.com/prime/726914793?bd=1 FI: 4.7, Q1

Lemini M, Ruiz-Herrera X, Ledesma-Colunga MG, Díaz-Lezama N, De Los Ríos EA, Lopez-Barrera F, Méndez I, Martinez de la Escalera G, Macotela Y*, Clapp C*. Prolactin anterior pituitary expression and circulating levels are reduced in obese and diabetic rats: Role of TGFβ and TNFα. Am J Physiol Regul Integr Comp Physiol. 2015, May 1:308(9):R792-9. doi: 10.1152/ajpregu.00327.2014 * Corresponding authors. FI: 3.1, Q2

Macotela Y, Emanuelli B, Mori M, Schulz T, Gesta S, Tseng Y, Kahn CR. Intrinsic Differences in Adipocyte Precursor Cells from Different White Fat Depots. Diabetes. 2012, Jul;61(7):1691-9. FI: 9.3, Q1

Macotela Y, Emanuelli B, Bang A, Espinoza D, Boucher J, Beebe K, Gall W, Kahn CR. Dietary Leucine - an Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism. PLoS One. 2011, 6:e21187. FI: 3.2, Q1. Commentary in Science Daily, June 2011. 

Macotela Y, Boucher J, Tran TT, Kahn CR. Gender and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism. Diabetes. 2009, 58:803-12. FI: 9.3, Q1

Macotela Y, Aguilar M, Guzmán-Morales J, Rivera JC, Zermeño C, Lopez-Barrera F, Nava G, Lavalle C, Martinez de la Escalera G and Clapp C. Matrix metalloproteases from chondrocytes generate an antiangiogenic 16kDa prolactin. Journal of Cell Science. 2006, 119:1790-800. FI: 5.2, Q1

Corbacho AM*, Macotela Y*, Nava G, Eiserich, JP, Cross CE, Martínez de la Escalera G, Clapp C. Cytokine induction of prolactin receptors mediates prolactin inhibition of nitric oxide synthesis in pulmonary fibroblasts. FEBS Letters. 2003, 544: 171-175. *Co-first authors. FI: 4.1, Q1

Macotela Y, Mendoza C, Corbacho AM, Cosío G, Eiserich JP, Zentella A,  Martínez de la Escalera G, Clapp C. 16K prolactin induces NF-kB activation in pulmonary fibroblasts. Journal of Endocrinology. 2002, 175:R13-R18. FI: 4.2, Q1

Becerril-Campos AA, Ramos-Gómez M, De Los Ríos-Arellano EA, Ocampo-Anguiano PV, González-Gallardo A, Macotela Y, García-Gasca T, Ahumada-Solórzano SM. Bean Leaves Ameliorate Lipotoxicity in Fatty Liver Disease. Nutrients. 2023, Jun 28;15(13):2928. doi: 10.3390/nu15132928 FI: 5.9, Q1

Martínez de la Escalera G, Macotela Y, Clapp C. A New Experimental Tool Toward Understanding the Regulation of Human Prolactin Secretion and Functions. Endocrinology. 2022 Apr 1;163(4):bqac021. FI: 4.7, Q1

Isidor MS, Dong W, Servin-Uribe RI, Villarroel J, Altıntaş A, Ayala-Sumuano JT, Varela-Echavarría A, Barrès R, Stephanopoulos G, Macotela Y, Emanuelli B. Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes. Int J Obes (Lond). 2022 Mar;46(3):535-543. doi: 10.1038/s41366-021-01021-y. FI: 5.1, Q1

Rodriguez-López LA, Torre-Villalvazo I, Aleman-Escondrillas G, Flores-López A, Guevara-Cruz M, Sánchez-Tapia M, Torre-Anaya EA, Martínez-López V, Vasquez-Reyes S, Torres-Villalobos GM, Macotela Y, Torres N, Tovar AR. The capacity of differentiation of stromal vascular fraction cells into beige adipocytes is markedly reduced in subjects with overweight/obesity and insulin resistance: effect of genistein. Int J Obes (Lond). 2021 Nov;45(11):2471-2481. FI: 5.1, Q1

Vázquez-Membrillo M, Siqueiros-Márquez L, Núñez FF, Díaz-Lezama N, Adán-Castro E, Ramírez-Hernández G, Adán N, Macotela Y, Martínez de la Escalera G, Clapp C. Prolactin stimulates the vascularisation of the retina in newborn mice under hyperoxia conditions. J Neuroendocrinol. 2020 Apr 25:e12858. FI: 3.6, Q2

Moreno-Carranza B, Bravo-Manríquez M, Baez A, Ledesma-Colunga MG, Ruiz-Herrera X, Reyes-Ortega P, de Los Ríos EA, Macotela Y, Martínez de la Escalera G, Clapp C. Prolactin regulates liver growth during postnatal development in mice. Am J Physiol Regul Integr Comp Physiol. 2018, 1;314(6):R902-R908. FI: 3.1, Q2

Vázquez-Cuevas, F., Aguilar-Roblero, R., Arellanes-Licea, E., Macotela, Y., Vázquez-Martínez, O., Villanueva, I., Díaz-Muñoz, M. Food Intake and Its Control by Signaling Molecules. In: Pfaff, D.W and Joëls, M. (editors-in-chief), Hormones, Brain, and Behavior 3rd edition, Vol 1. Oxford: Academic Press; 2017. pp. 175–209. 

Triebel J, Moreno-Vega AI, Vázquez-Membrillo M, Nava G, García-Franco R, López-Star E, Baldivieso-Hurtado O, Ochoa D, Macotela Y, Bertsch T, Martinez de la Escalera G, Clapp C. High Prolactin Excretion in Patients with Diabetes Mellitus and Impaired Renal Function. Clin Lab. 2015;61(7):709-16. FI: 1.1, Q3

Clapp C, Thebault S, Macotela Y, Moreno-Carranza B, Triebel J, Martínez de la Escalera G. Regulation of blood vessels by prolactin and vasoinhibins. Adv Exp Med Biol. 2015;846:83-95. doi: 10.1007/978-3-319-12114-7_4. FI: 2.0, Q1 en 2015, Q3 en 2021.

Ussar S, Dankel S, Boucher J, Lee K, Haering MF, Kleinridders A, Xue R, Macotela Y, Cypess AM, Tseng YH, MellgrenG, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Science Translational Medicine. 2014, 6(247):247ra103. FI: 16.3, Q1

Londraville RL, Macotela Y, Duff RJ, Easterling MR, Liu Q, Crespi EJ. Comparative endocrinology of leptin: Expanding our understanding of function across vertebrates. General Comparative Endocrinology. 2014, Feb 11. pii: S0016-6480(14)00045-8. doi: 10.1016/j.ygcen.2014.02.002. FI: 2.5, Q1

Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, Larsson NG, Kahn CR. Adipose-Specific Deletion of TFAM Induces Mitochondrial Dysfunction and Protects Mice against Obesity and Insulin Resistance. Cell Metabolism. 2012,16(6):765-76. FI: 16.74, Q1

Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TJ, Kahn CR. Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity. Cell Metabolism. 2012,16(3): 336-47. FI: 16.74, Q1

Boucher J, Mori MA, Lee KY, Smyth G, Liew CW, Macotela Y, Rourk M, Bluher M, Russell SJ, Kahn CR. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun. 2012 Jun 12;3:902. doi: 10.1038/ncomms1905. FI: 17.6, Q1

Triebel J, Macotela Y, Martínez de la Escalera G, Clapp C. Prolactin and vasoinhibins: Endogenous players in diabetic retinopathy. IUBMB Life. 2011, Oct;63(10):806-10. FI: 4.7, Q2

Gesta S, Bezy O, Mori MA, Macotela Y, Lee KY, Kahn CR. Mesodermal developmental gene Tbx15 impairs adipocyte differentiation and mitochondrial respiration. Proc Natl Acad Sci U S A. 2011, 108:2771-6.  FI: 12.7, Q1

Boucher J, Macotela Y, Bezy O, Mori M, Kriauciunas C, Kahn CR. A Kinase-Independent Role for Unoccupied Insulin and IGF-1 Receptors in the Control of Apoptosis. Science Signaling. 2010, 3:ra87. FI: 8.1, Q1

Emanuelli B, Macotela Y, Boucher J, Kahn CR. SOCS-1 deficiency does not prevent diet-induced insulin resistance.Biochem Biophys Res Commun. 2008, 377:447-52. FI: 2.6, Q1 

García C, Aranda J, Arnold E, Thébault S, Macotela Y, López-Casillas F, Mendoza V, Quiroz-Mercado H, Hernández-Montiel HL, Lin SH, de la Escalera GM, Clapp C. Vasoinhibins prevent retinal vasopermeability associated with diabetic retinopathy in rats via protein phosphatase 2A-dependent eNOS inactivation. Journal of Clinical Investigation. 2008, 118:2291-300. FI: 14.8, Q1 

González C, Parra A, Ramírez-Peredo J, García C, Rivera JC, Macotela Y, Aranda J, Lemini M, Arias J, Ibargüengoitia F, de la Escalera GM, Clapp C. Elevated vasoinhibins may contribute to endothelial cell dysfunction and low birth weight in preeclampsia. Laboratory Investigation. 2007, 87:1009-17. FI: 5.5, Q1

Clapp C, Gonzalez C, Macotela Y, Aranda J, Rivera JC, Garcia C, Guzman J, Zamorano M, Vega C, Martin C, Jeziorski MC, Martinez de la Escalera G. Vasoinhibins: A Family of N-Terminal Prolactin Fragments that Inhibit Angiogenesis and Vascular Function. Frontiers in Hormone Research. 2006, 35:64-73. FI: 2.1, Q2

Zermeño C, Guzmán-Morales J, Macotela Y, Nava G, Lopez-Barrera F, Kouri JB, Lavalle C, Martinez de la Escalera G and Clapp C. Prolactin inhibits the apoptosis of chondrocytes induced  by serum starvation. Journal of Endocrinology. 2006, 189:R1-R8. FI: 4.2, Q1

Montes de Oca P, Macotela Y, Nava G, López-Barrera F, Martínez de la Escalera G, Clapp C. Prolactin stimulates integrin mediated adhesion of circulating mononuclear cells to endothelial cells. Laboratory Investigation. 2005, 85(5):633-42. FI: 5.5, Q1

Dueñas Z, Rivera JC, Quiróz-Mercado H, Aranda J, Macotela Y, Montes de Oca P, López-Barrera F, Nava G, Guerrero JL, Suarez A, De Regil M, Martinez de la Escalera G, Clapp C. Prolactin in the eye of patients with retinopathy of prematurity: implications for vascular regression. Investigative Ophthalmology & Visual Science. 2004, 45:2049-2055. FI: 4.9, Q1

Corbacho AM, Nava G, Eiserich JP, Noris G, Macotela Y, Struman I, Martinez de la Escalera G, Freeman B, Clapp C. Proteolytic cleavage confers NO synthase inducing activity upon prolactin. Journal of Biological Chemistry. 2000, 275(18):13183-13186. IF: 4.2, Q1

Corbacho A, Macotela Y, Nava G, Torner L, Dueñas Z, Noris G, Morales MA, Martínez de la Escalera G, Clapp C. Human umbilical vein endothelial cells express multiple prolactin isoforms. Journal of Endocrinology. 2000, 166:53-62. IF: 4.1, Q1

Clapp C, López-Gómez FJ, Nava G, Corbacho A, Torner L, Macotela Y,  Dueñas Z, Ochoa A, Noris G, Acosta E, Garay E, Martínez de la Escalera G. Expression of prolactin mRNA and of prolactin-like proteins in endothelial cells: evidence for autocrine effects. Journal of Endocrinology. 1998, 158:137-144. IF: 4.1, Q1

Dominguez V, Gevorkian G, Govezensky T, Rodriguez H, Viveros M, Cocho G, Macotela Y, Masso F, Pacheco M, Estrada JL, Lavalle C, Larralde C. Antigenic Homology of HIV-1 GP41 and human platelet glycoprotein GPIIIa (integrin b3). Journal of Acquired Immune Deficiency Syndromes. 1998, 17:385-90. IF: 3.7, Q1