Publications

6. MacKenzie, I. "Cation Radical-Mediated SNAr: A Modern Realization Of An Old Discovery." ChemPhotoChem, 2025, https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cptc.202500268

Cation Radical‐Mediated Nucleophilic Aromatic Substitution (SNAr): A Modern Realization of an Old DiscoveryThe modern field of oxidatively activated nucleophilic aromatic substitution (SNAr) is reviewed in the context of important historical precedent. A correction to modern terminology is proposed and op...

Publications Prior to Muhlenberg

5. Konzal, J.; Murley, M.; Wolter, A.; Camou, L.; Oberbroeckling, A.; Dekker, M.; Wagner, G.; Jennejohn, K.; Peters, M.; Hayes, N.; Franklin, C.; Tobin, S.; Collier, E.; MacKenzie, I. "Towards Designer Photocatalysts: Structure-Property Relationships in 2,6-Diaryl-pyryliums." Chemistry - A European Journal, 2024, https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202403543

Towards Designer Photocatalysts: Structure‐Property Relationships in 2,6‐Diaryl‐pyryliumsKey design parameters and linear free-energy relationships were elucidated for 2,6-diarylpyrylium photocatalysts, allowing broad range control over both photophysical and electrochemical properties. ...

4. Boyden, B.; Tobin, S.; Haen, N.; Metz, A.; Wojnowiak, C.; Taylor, T.; Cutty, A.; Litza, A.; Stiles, I.; Soehner, N.; Oberbroeckling, A.; O'Leary, N.; Popp, H.; MacKenzie, I. "Photomediated Hexafluoroisopropoxylation of Unactivated Aryl Halides." Chemistry - A European Journal, 2024, https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202402811

3. Cruz, C. L.; Holmberg-Douglas, N.; Onuska, N. P. R.; McManus, J. B.; MacKenzie, I. A.; Hutson, B. L.; Eskew, N. A.; Nicewicz, D. A. "Development of a Large-Enrollment Course-Based Research Experience in an Undergraduate Organic Chemistry Laboratory: Structure–Function Relationships in Pyrylium Photoredox Catalysts." J. Chem. Educ. 2020, 97, 6, 1572-1578. https://pubs.acs.org/doi/full/10.1021/acs.jchemed.9b00786

2. MacKenzie, I.; Wang, L.; Onuska, N.; Williams, O.; Begam, K.; Moran, A.; Dunietz, B.; Nicewicz, D. "Discovery and characterization of an acridine radical photoreductant." Nature 580, 76–80 (2020). https://www.nature.com/articles/s41586-020-2131-1

Discovery and characterization of an acridine radical photoreductant - NaturePhotoexcited acridine radical catalysts are found to have redox potentials more reducing than lithium, which is attributed to the population of higher-energy doublet excited states via a twisted intramolecular charge-transfer species.

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1. Dongare, P.; MacKenzie, I.; Wang, D.; Nicewicz, D.; Meyer, T. J. “Oxidation of alkyl benzenes by a flavin photooxidation catalyst on nanostructured metal-oxide films.” Proc. Natl. Acad. Sci. U.S.A., 2017, 114, 9279-9283. https://www.pnas.org/doi/10.1073/pnas.1707318114

Oxidation of alkyl benzenes by a flavin photooxidation catalyst on nanostructured metal-oxide films | PNASWe describe here a surface-bound, oxide-based procedure for the photooxidation of a family of aromatic hydrocarbons by a phosphate-bearing flavin m...