Fitness landscapes

Epistasis and evolution in fitness landscapes

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• We developed a new set of measures of epistasis in fitness landscapes [3], the theory of divergence of ortholog sequences and long-term evolution in the protein universe with multidimensional epistasis [4], characterization of NK models of fitness landscapes [2] and analysis of evolutionary constraints imposed by landscape features [1].

  1. Ferretti L, Weinreich D and Achaz G, “Evolutionary constraints in fitness landscapes”, Heredity (2018).

  2. Hwang S, Schmiegelt B, Ferretti L and Krug J, “Universality classes of interaction structures for NK fitness landscapes”, Journal of Statistical Physics (2018).

  3. Ferretti L, Schmiegelt B, Weinreich D, Yamauchi A, Kobayashi Y, Tajima F and Achaz G, “Measuring epistasis in fitness landscapes: the correlation of fitness effects of mutations”, Journal of Theoretical Biology, 396:132-143 (2016).

  4. Usmanova DR, Ferretti L, Povolotskaya IS, Vlasov PK, Kondrashov FA, A model of substitution trajectories in sequence space and long-term protein evolution, Mol. Biol. Evol. 32(2):542- 54 (2015).