Publication

Research Articles:

1.     Liu S, Deshmukh V, Meng F, Wang Y, Morikawa Y, Steimle JD, Li RG, Wang J, and Martin JF. Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration. Circulation. 2024. (https://doi.org/10.1161/CIRCULATIONAHA.123.067646)

2.     Liu S, Deshmukh V, Wang F, Liang J, Cusick J, Li X, and Martin JF. Myocardial Infarction Suppresses Protein Synthesis and Causes Decoupling of Transcription and Translation. JACC Basic Transl Sci. 2024;9:792-807. (co-corresponding author)

Commented by Thomas G. Martin and Leslie A. Leinwand. Turn(over) the Page: Advancing Understanding of Proteome Dynamics After Heart Attack. JACC: Basic to Translational Science. 2024 Jun, 9 (6) 808–810 (10.1016/j.jacbts.2024.05.002)

3.      Yuka Morikawa, Jong Kim, Gang Li, Lin Liu, Shijie Liu, Vaibhav Deshmukh, Matthew Hill, and James Martin. YAP Overcomes Mechanical Barriers to Induce Mitotic Rounding and Adult Cardiomyocyte Division. Circulation. (https://doi.org/10.1161/CIRCULATIONAHA.123.066004)

4.     Liu S, Gammon ST, Tan L, Gao Y, Kim K, Williamson IK, Pham J, Davidian A, Khanna R, Gould BD, Salazar R, Vitrac H, Dinh A, Lien EC, de LVFN, Gongora JM, Martinez SA, Lawrence CSC, Kransdorf EP, Leffer D, Hanson B, Garcia BA, Vander Heiden MG, Lorenzi PL, Taegtmeyer H, Piwnica-Worms D, Martin JF and Karlstaedt A. ATP-dependent citrate lyase Drives Left Ventricular Dysfunction by Metabolic Remodeling of the Heart. bioRxiv. 2024. (https://doi.org/10.1101/2024.06.21.600099)

5.     Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang, Yufeng Shi, Rich G Li, Bing Xie, Vaibhav Deshmukh, Shijie Liu, Xiao Li, James F Martin. SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling. eLife. 2024 (https://doi.org/10.7554/eLife.100248.1)

6.     Li RG, Li X, Morikawa Y, Grisanti-Canozo FJ, Meng F, Tsai CR, Zhao Y, Liu L, Kim J, Xie B, Klysik E, Liu S, Samee MAH and Martin JF. YAP induces a neonatal-like pro-renewal niche in the adult heart. Nat Cardiovasc Res. 2024;3:283-300.

7. Zhang S, Liu S, Leach JP, Li K, Perin EC and Martin JF. Gene Therapy Knockdown of Hippo Signaling Resolves Arrhythmic Events in Pigs After Myocardial Infarction. Circulation. 2022;146:1558-1560. (co-first author)

8. Franklin DA, Liu S, Jin A, Cui P, Guo Z, Arend KC, Moorman NJ, He S, Wang GG, Wan YY, and Zhang Y. Ribosomal protein RPL11 haploinsufficiency causes anemia in mice via activation of the RP-MDM2-p53 pathway. J Biol Chem. 2022:102739. (co-first author)

9. Liu S, Tang L, Zhao X, Nguyen B, Heallen TR, Li M, Wang J, Wang J, and Martin JF. Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration. Circ Res. 2021;129:782-797. (Featured article)

Commented by Junchi Sadoshima. YAP Promotes Infarct Resolution by Stimulating Intercellular Signaling Circ Res. 2021;129:798-800.

10.   Liu S, Li K, Wagner Florencio L, Tang L, Heallen TR, Leach JP, Wang Y, Grisanti F, Willerson JT, Perin EC, Zhang S and Martin JF. Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction. Sci Transl Med. 2021;13.

11.   Liu Q, Pan S, Liu S, Zhang S, Willerson JT, Martin JF and Dixon RAF. Suppressing Hippo signaling in the stem cell niche promotes skeletal muscle regeneration. Stem Cells. 2021;39:737-749.

12.   Zhang X, Liu S, Wang Y, Hu H, Li L, Wu Y, Cao D, Cai Y, Zhang J and Zhang X. Interleukin‑22 regulates the homeostasis of the intestinal epithelium during inflammation. Int J Mol Med. 2019;43:1657-1668.

13.   Gao G, Wei G, Liu S, Chen J, Zeng Z, Zhang X, Chen F, Zhuo L, Hsu W, Li D, Liu M and Zhang X. Epithelial Wntless is dispensable for intestinal tumorigenesis in mouse models. Biochem Biophys Res Commun. 2019;519:754-760.

14.   Liu S, Tackmann NR, Yang J and Zhang Y. Disruption of the RP-MDM2-p53 pathway accelerates APC loss-induced colorectal tumorigenesis. Oncogene. 2017;36:1374-1383.

15.   Liu S, Kim TH, Franklin DA and Zhang Y. Protection against High-Fat-Diet-Induced Obesity in MDM2(C305F) Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure. Cell Rep. 2017;18:1005-1018.

16.   Meng X, Tackmann NR, Liu S, Yang J, Dong J, Wu C, Cox AD and Zhang Y. RPL23 Links Oncogenic RAS Signaling to p53-Mediated Tumor Suppression. Cancer Res. 2016;76:5030-9.

17.   Guan Y, Zhang L, Li X, Zhang X, Liu S, Gao N, Li L, Gao G, Wei G, Chen Z, Zheng Y, Ma X, Siwko S, Chen JL, Liu M and Li D. Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models. J Immunol. 2015;195:339-46.

18.   Pan H, Cui H, Liu S, Qian Y, Wu H, Li L, Guan Y, Guan X, Zhang L, Fan HY, Ma Y, Li R, Liu M and Li D. Lgr4 gene regulates corpus luteum maturation through modulation of the WNT-mediated EGFR-ERK signaling pathway. Endocrinology. 2014;155:3624-37.

19.   Qian Y, Liu S, Guan Y, Pan H, Guan X, Qiu Z, Li L, Gao N, Zhao Y, Li X, Lu Y, Liu M and Li D. Lgr4-mediated Wnt/beta-catenin signaling in peritubular myoid cells is essential for spermatogenesis. Development. 2013;140:1751-61. (co-first author)

20.   Liu S, Qian Y, Li L, Wei G, Guan Y, Pan H, Guan X, Zhang L, Lu X, Zhao Y, Liu M and Li D. Lgr4 gene deficiency increases susceptibility and severity of dextran sodium sulfate-induced inflammatory bowel disease in mice. J Biol Chem. 2013;288:8794-803; discussion 8804. (Paper of the Week)

Review Articles/Commentaries:

      1.   A Rojas, S Dahlen, F Zhang, S Liu. The Cytoskeletal Structure in Cardiomyocyte Maturation and Proliferation Cells. 2025; 12(19), 1494.

      2.   Liu S and Martin JF. RNA splicing to cytoskeleton: A new path to cardiomyocyte ploidy and division? Dev Cell. 2022;57:945-946.

      3.   Liu S, Li RG and Martin JF. The cell-autonomous and non-cell-autonomous roles of the Hippo pathway in heart regeneration. J Mol Cell Cardiol. 2022;168:98-106.

      4.   Liu S and Martin JF. The regulation and function of the Hippo pathway in heart regeneration. Wiley Interdiscip Rev Dev Biol. 2019;8:e335.

      5.   Wang J, Liu S, Heallen T and Martin JF. The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration. Nat Rev Cardiol. 2018;15:672-684.