RESEARCH
RESEARCH
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Our laboratory harnesses the power of biology to tackle a wide range of critical global challenges, focusing on CO2 conversion and utilization, as well as renewable biomanufacturing with carbon-negative technology. Through the application of metabolic engineering, synthetic biology, and systems biology, we aim to fundamentally rewrite the central metabolism and modify the regulations in microorganisms, enabling the production of low-carbon biochemicals.
Synthetic Biology
Synthetic biology is a scientific discipline that focuses on redesigning organisms to serve specific purposes by introducing new functionalities through engineering.
In our laboratory, we have created a CO2-fixing system different from nature. Additionally, we have created a synthetic E. coli that relies non-oxidative glycolysis (NOG) for sugar catabolism.
Metabolic Engineering
Metabolic engineering involves the targeted manipulation of cellular chemistry.
In our laboratory, we have developed tools to facilitate metabolic engineering in microorganisms and applied these tools to the production of biofuels. Specifically, we have engineered Clostridium thermocellum to directly produce isobutanol from cellulose in a minimal medium.
Genome Editing
Genome editing is a form of genetic engineering that involves the insertion, deletion, modification, or replacement of DNA within the genome of a living organism.
In our laboratory, we employ CRISPR-Cas9 and Lambda Red-mediated recombineering techniques to carry out precise genome editing in microorganisms.
Protein Engineering
Protein engineering involves the design and creation of synthetic polypeptides by modifying natural amino acid sequences.
In our research, we have utilized directed evolution to improve the thermostability of Keto acid decarboxylase (Kdc), a key enzyme in the biosynthesis pathway of isobutanol.
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