Publications

32. Lee E, Choi SY, Song SM, Lindroth AM*, Park YJ. AMPK inhibition and elevated angiogenin are associated with tRNA fragmentation in the male germline exposed to a high-fat diet. Molecular Metabolism. 2026 Mar 12:102350. doi: 10.1016/j.molmet.2026.102350. *Co-corresponding authors. 

31. Verma A, Lindroth AM (2025). The emerging intertwined activities of metabolism and epigenetics unveils culprits and prospects in cancer. Experimental & Molecular Medicine. 2025 Sep 12. doi: 10.1038/s12276-025-01537-7. IF12.5

30. Park YJ, Song S, Han Y, Lindroth AM (2024). Nutriepigenomics: Paving the way for personalized nutrition. In Personalized Epigenetics, Chapter 11, 2nd ed. Trygve Tollefsbol (Ed.), Elsevier, July 17, Paperback ISBN: 9780443238024, eBook ISBN: 9780443238031

29. Shon J, Han Y, Song S, Kwon S, Na K, Lindroth AM, Park YJ (2024). Anti-obesity effect of butyrate links to modulation of gut microbiome and epigenetic regulation of muscular circadian clock. Journal of Nutritional Biochemistry (2 Feb 2024). IF4.8

28. Lee E, Lim J, Lee S, Park YJ, Lindroth AM (2024). H3.3-G34W in giant cell tumor of bone functionally align with the exon choice repressor hnRNPA1L2. Cancer Gene Therapy. May 29. doi: 10.1038/s41417-024-00776-6. IF4.8

27. Yoon SY, Lindroth AM, Kwon S, Park SY, Park YJ (2022). Adenosine derivatives from Cordyceps exert antitumor effects against ovarian cancer cells through ENT1-mediated transport, induction of AMPK signaling, and consequent autophagic cell death. Biomedicine & Pharmacotherapy, Vol 153, Sept 2022, 113491. IF7.5

26. Lutsik P, Baude A, Mancarella D, Öz S, Kühn A, Toth R, Hey J, Toprak UH, Lim J, Nguyen VH, Jiang C, Mayakonda A, Hartmann M, Rosemann F, Breuer K, Vonficht D, Grünschläger F, Lee S, Schuhmacher MK, Kusevic D, Jauch A, Weichenhan D, Zustin J, Schlesner M, Haas S, Park JH, Park YJ, Oppermann U, Jeltsch A, Haller F, Fellenberg J, Lindroth AM*, Plass C* (2020). Globally altered epigenetic landscape and lagging osteogenic differentiation in H3.3-G34W-mutant giant cell tumor of bone. Nature Communications. Oct 27;11(1):5414. *Co-corresponding authors.

25. Kim H, Choi SY, Lim J, Lindroth AM, Park YJ (2020). EHMT2 Inhibition Induces Cell Death in Human Non-Small Cell Lung Cancer by Altering the Cholesterol Biosynthesis Pathway. International Journal of Molecular Sciences Feb 3;21(3).

24. Lindroth AM, Park YJ, Matía V, Squatrito M (2020). The mechanistic GEMMs of oncogenic histones. Human Molecular Genetics, 2020 Oct 20; doi: 10.1093/hmg/ddaa143.

23. Fellenberg J, Sähr H, D. Mancarella D, Plass C, Lindroth AM, Westhauser F, Lehner B, Ewerbeck V (2019). Knock-down of mutated H3F3A-G34W counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells. Cancer Letters 2019 Apr 28. pii: S0304-3835(19)30063-1.

22. Lim J, Park JH, Baude A, Fellenberg J, Zustin J, Haller F, Krücken I, Kang HG, Park YJ, Plass C, Lindroth AM (2018). Transcriptome and protein interaction profiling in cancer cells with mutations in histone H3.3. Scientific Data 5, ePub December 11.

21. Park JH, Yoo Y, Cho M, Lim J, Lindroth AM*, Park YJ* (2018). Diet-induced obesity leads to metabolic dysregulation in offspring via endoplasmic reticulum stress in a sex-specific manner. International Journal of Obesity (Lond). 2018 Feb;42(2):244-251. *Co-corresponding authors.

20. Lim J, Park JH, Baude A, Yoo Y, Lee YK, Schmidt CR, Park JB, Fellenberg J, Zustin J, Haller F, Krücken I, Kang HG, Park YJ, Plass C, Lindroth AM (2017). The histone variant H3.3 G34W substitution in giant cell tumor of the bone link chromatin and RNA processing. Scientific Reports. 2017 Oct 18;7(1):13459. doi: 10.1038/s41598-017-13887-y.

19. Pandzic T, Rendo V, Lim J, Larsson C, Larsson J, Stoimenov I, Kundu S, Ali MA, Hellström M, He L, Lindroth AM, Sjöblom T (2017). Somatic PRDM2 c.4459delA mutations in colorectal cancers control histone methylation and tumor growth. Oncotarget 2017 Oct 9;8(58):98646-98659.

18. Larsson C, Ali MA, Pandzic T, Lindroth AM, He L, Sjöblom T (2017). Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition. BMC Cancer. Jul 17;17(1):487.

17. Brocks D, Schmidt CR, Daskalakis M, Jang HS, Shah NM, Li D, Li J, Zhang B, Hou Y, Laudato S, Lipka DB, Schott J, Bierhoff H, Assenov Y, Helf M, Ressnerova A, Islam MS, Lindroth AM, Haas S, Essers M, Imbusch CD, Brors B, Oehme I, Witt O, Lübbert M, Mallm JP, Rippe K, Will R, Weichenhan D, Stoecklin G, Gerhäuser C, Oakes CC, Wang T, Plass C (2017). DNMT and HDAC inhibitors induce cryptic transcription start sites encoded in long terminal repeats. Nature Genetics. Jul;49(7):1052-1060. Epub 2017 Jun 12.

16. Yoo Y, Park JH, Weigel C, Liesenfeld D, Weichenhan D, Plass C, Seo DG, Lindroth AM, Park YJ (2017). TET-mediated hydroxymethylcytosine at the Pparγ locus is required for initiation of adipogenic differentiation. International Journal of Obesity; 41, 652-659 (21 Febr. 2017).

15. Lee G, Joo JC, Choi BY, Lindroth AM, Park SJ, Park YJ (2016). Neuroprotective effects of Paeonia lactiflora extract against cell death of dopaminergic SH-SY5Y cells is mediated by epigenetic modulation. BMC Complementary and Alternative Medicine, 2016 Jul 12; 16:208.

14. Lindroth AM, Park JH, Yoo Y, Park YJ (2015). Nutrigenomics: Personalized nutrition meets epigenetics. Personalized Epigenetics, 1st ed. Trygve Tollefsbol (Ed.), pp. 311-345.

13. Arab K, Park YJ, Lindroth AM, Schäfer A, Oakes CC, Weichenhan D, Lukanova A, Lundin E, Risch A, Meister M, Dienemann H, Dyckhoff G, Herold-Mende C, Grummt I, Niehrs C, Plass C (2014). Long Noncoding RNA TARID Directs Demethylation and Activation of the Tumor Suppressor TCF21 via GADD45A. Molecular Cell, Aug 21; 55: 1-11.

12. Almouzni G, Altucci L, …, Lindroth A, …, Widschwendter M (2014). Relationship between genome and epigenome – challenges and requirements for future research. BMC Genomics, June 18; 15(1): 487. Authors equal contributions.

11. Lindroth AM, Park YJ, Plass C (2015). Epigenetic reprogramming in cancer. Epigenetics and Human Health (series): Epigenetic Mechanisms in Cellular Reprogramming. Alex Meissner and Jörn Walter (Eds.). ISBN 978-3-642-31974-7.

10. Baude A, Lindroth AM, Plass C (2014). PRC2 loss amplifies Ras signaling in cancer. Nature Genetics, 2014 Nov:1154-5. doi: 10.1038/ng.3124.

9.  Lindroth AM, Plass C (2013). Recurrent H3.3 alterations in childhood tumors. Nature Genetics, 2013 Nov 25;45(12):1413-4. doi: 10.1038/ng.2832.

8.  Plass C, Pfister SM, Lindroth AM, Bogatyrova O, Claus R, Lichter P (2013). Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer. Nature Reviews Genetics, Nov 14 (11): 765-80.

7.  Bender S*, Tang Y*, Lindroth AM*, Hovestadt V, Jones DT, Kool M, Zapatka M, Northcott PA, Sturm D, Wang W, Radlwimmer B, Højfeldt JW, Truffaux N, Castel D, Schubert S, Ryzhova M, Şeker-Cin H, Gronych J, Johann PD, Stark S, Meyer J, Milde T, Schuhmann M, Ebinger M, Monoranu CM, Ponnuswami A, Chen S, Jones C, Witt O, Collins VP, von Deimling A, Jabado N, Puget S, Grill J, Helin K, Korshunov A, Lichter P, Monje M, Plass C§, Cho YJ§, Pfister SM§ (2013). Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell, Nov 11; 24(5): 660-72. *equal contributions; §co-corresponding authors.

6.  Tönjes M, Barbus S, Park YJ, Wang W, Schlotter M, Lindroth AM, Pleier SV, Bai AHC, Karra D, Piro RM, Felsberg J, Addington A, Lemke D, Weibrecht I, Hovestadt V, Rolli CG, Campos B, Turcan S, Sturm D, Witt H, Chan TA, Herold-Mende C, Kemkemer R, König R, Schmidt K, Hull WE, Pfister SM, Jugold M, Hutson SM, Plass C, Okun JG, Reifenberger G, Lichter P, Radlwimmer B (2013). BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1. Nature Medicine, Jul; 19(7): 901-8.

5.  Lindroth AM, Park YJ (2013). Epigenetic biomarkers: a step forward for understanding periodontitis. Journal of Periodontal & Implant Science, Jun; 43(3):111-20.

4.  Haas J, Frese KS, Park YJ, Keller A, Vogel B, Lindroth AM, Weichenhan D, Franke J, Fischer S, Bauer A, Marquart S, Sedaghat-Hamedani F, Kayvanpour E, Köhler D, Wolf NM, Hassel S, Nietsch R, Wieland T, Ehlermann P, Schultz JH, Dösch A, Mereles D, Hardt S, Backs J, Hoheisel JD, Plass C, Katus HA, Meder B (2013). Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Molecular Medicine. 2013 Mar 5(3): 413-29, doi: 10.1002/emmm.201201553. Epub 2013 Jan 22.

3.  Sturm D, Witt H, Hovestadt V, Khuong-Quang DA, Jones DT, Konermann C, Pfaff E, Tönjes M, Sill M, Bender S, Kool M, Zapatka M, Becker N, Zucknick M, Hielscher T, Liu XY, Fontebasso AM, Ryzhova M, Albrecht S, Jacob K, Wolter M, Ebinger M, Schuhmann MU, van Meter T, Frühwald MC, Hauch H, Pekrun A, Radlwimmer B, Niehues T, von Komorowski G, Dürken M, Kulozik AE, Madden J, Donson A, Foreman NK, Drissi R, Fouladi M, Scheurlen W, von Deimling A, Monoranu C, Roggendorf W, Herold-Mende C, Unterberg A, Kramm CM, Felsberg J, Hartmann C, Wiestler B, Wick W, Milde T, Witt O, Lindroth AM, Schwartzentruber J, Faury D, Fleming A, Zakrzewska M, Liberski PP, Zakrzewski K, Hauser P, Garami M, Klekner A, Bognar L, Morrissy S, Cavalli F, Taylor MD, van Sluis P, Koster J, Versteeg R, Volckmann R, Mikkelsen T, Aldape K, Reifenberger G, Collins VP, Majewski J, Korshunov A, Lichter P, Plass C, Jabado N, Pfister SM (2012). Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. Cancer Cell, Oct 16; 22(4): 425-37, doi: 10.1016/j.ccr.2012.08.024.

2.  Park YJ, Herman H, Gao Y, Lindroth AM, Hu BY, Murphy PJ, Putnam JR, Soloway PD (2012). Sequences sufficient for programming imprinted germline DNA methylation defined. PLoS One, 7(3): e33024.

1.  Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N (2012). Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma. Nature, Jan 29: 482 (7384): 226-31.