Publications

p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL.

Yu HC, Jeon YG, Na AY, Han CY, Lee MR, Yang JD, Yu HC, Son JB, Kim ND, Kim JB, Lee S, Bae EJ#, Park BH# (#equal contribution) 

Nature Metabolism 2024;6(1):94-112. 

p21-activated kinase 4 suppresses fatty acid β-oxidation and ketogenesis by phosphorylating NCoR1.

Shi MY, Yu HC, Han CY, Bang IH, Park HS, Jang KY, Lee S, Son JB, Kim ND, Park BH#, Bae EJ# (#equal contribution) 

Nature Communications 2023;17;14(1):4987. 

Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.

Kim YS, Ko B, Kim DJ, Tak J, Han CY, Cho JY, Kim W, Kim SG 

Nature Communications 2022;13(1):6080.

Loss of ERdj5 exacerbates oxidative stress in mice with alcoholic liver disease via suppressing Nrf2.

Hong DG, Song GY, Eom CB, Ahn JH, Kim SM, Shim A, Han YH, Roh YS, Han CY, Bae EJ, Ko HJ, Yang YM

Free Radical Biology and Medicine 2022;184:42-52.

Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue.

Park S, Song J, Baek IJ, Jang KY, Han CY, Jun DW, Kim PK, Raught B, Jin EJ 

Experimental & Molecular Medicine 2021;53(7):1159-1169.

LXRα activation inhibits autophagy and lipophagy in hepatocytes by dysregulating ATG4B and Rab-8B, reducing mitochondrial fuel oxidation.

Kim YS, Nam HJ, Han CY, Joo MS, Jang K, Jun DW, Kim SG

Hepatology 2021;73(4):1307-1326.

Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα13 in liver exacerbates systemic insulin resistance in mice.

Kim TH, Koo JH, Heo MJ, Han CY, Kim YI, Park SY, Cho IJ, Lee CH, Choi CS, Lee JW, Kim W, Cho JY, Kim SG

Science Translational Medicine 2019;11(513).

Rhodanthpyrone A and B play an anti-inflammatory role by suppressing the nuclear factor-κB pathway in macrophages.

Kim KS*, Han CY*, Han YT, Bae EJ (*equal contribution)

Korean Journal of Physiology & Pharmacology 2019;23(6):493-499.

Future Directions of Pharmacovigilance Studies Using Electronic Medical Recording and Human Genetic Databases.

Choi YH*, Han CY*, Kim KS, Kim SG (*equal contribution)

Toxicological Research 2019;35(4):319-330. (Review)

Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.

Park SJ, Cho SS, Kim KM, Yang JH, Kim JH, Jeong EH, Yang JW, Han CY, Ku SK, Cho IJ, Ki SH

Toxicology and Applied Pharmacology 2019;379:114665.

Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration.

Kim TH, Yang YM, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG

Journal of Clinical Investigation 2018;128(12):5587-5602.

Gα12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells.

Kim KM, Han CY, Kim JY, Cho SS, Kim YS, Koo JH, Lee JM, Lim SC, Kang KW, Kim JS, Hwang SJ, Ki SH, Kim SG

Journal of Hepatology 2018;68(3):493-504.

Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism.

Koo JH, Kim TH, Park SY, Joo MS, Han CY, Choi CS, Kim SG

Journal of Clinical Investigation 2017;127(10):3845-3860.

Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function.

Han CY*, Kim TH*, Koo JH, Kim SG (*equal contribution)

Archives of Pharmacal Research 2016;39(8):1062-74. (Review)

SIRT1-mediated FoxO1 deacetylation is essential for multidrug resistance-associated protein 2 expression in tamoxifen-resistant breast cancer cells.

Choi HK, Cho KB, Phuong NT, Han CY, Han HK, Hien TT, Choi HS, Kang KW

Molecular Pharmaceutics 2013;10(7):2517-27.

Ajoene, a stable garlic by-product, inhibits high fat diet-induced hepatic steatosis and oxidative injury through LKB1-dependent AMPK activation.

Han CY, Ki SH, Kim YW, Noh K, Lee da Y, Kang B, Ryu JH, Jeon R, Kim EH, Hwang SJ, Kim SG

Antioxidants & Redox Signaling 2011;14(2):187-202.

G(alpha)12/13 induction of CYR61 in association with arteriosclerotic intimal hyperplasia: effect of sphingosine-1-phosphate.

Kim YM, Lim SC, Han CY, Kay HY, Cho IJ, Ki SH, Lee MY, Kwon HM, Lee CH, Kim SG

Arteriosclerosis, Thrombosis and Vascular Biology 2011;31(4):861-9.

Role of Pin1 in UVA-induced cell proliferation and malignant transformation in epidermal cells.

Han CY, Hien TT, Lim SC, Kang KW

Biochemical and Biophysical Research Communications 2011;410(1):68-74.

E-cadherin antagonizes transforming growth factor β1 gene induction in hepatic stellate cells by inhibiting RhoA-dependent Smad3 phosphorylation.

Cho IJ, Kim YW, Han CY, Kim EH, Anderson RA, Lee YS, Lee CH, Hwang SJ, Kim SG

Hepatology 2010;52(6):2053-64.

Transactivation of genes encoding for phase II enzymes and phase III transporters by phytochemical antioxidants.

Yang YM, Noh K, Han CY, Kim SG

Molecules 2010;15(9):6332-48. (Review)

AMPK-associated signaling to bridge the gap between fuel metabolism and hepatocyte viability.

Yang YM, Han CY, Kim YJ, Kim SG

World Journal of Gastroenterology 2010;16(30):3731-42. (Review)

Role of FoxO1 activation in MDR1 expression in adriamycin-resistant breast cancer cells.

Han CY, Cho KB, Choi HS, Han HK, Kang KW

Carcinogenesis 2008;29(9):1837-44.

Induction of ErbB2 by ultraviolet A irradiation: potential role in malignant transformation of keratinocytes.

Han CY, Lim SC, Choi HS, Kang KW

Cancer Science 2008;99(3):502-9.

Induction of multidrug resistance associated protein 2 in tamoxifen-resistant breast cancer cells.

Choi HK, Yang JW, Roh SH, Han CY, Kang KW

Endocrine-Related Cancer 2007;14(2):293-303.

Induction of glutathione transferase in insulin-like growth factor type I receptor-overexpressed hepatoma cells.

Lee JY*, Han CY*, Yang JW*, Smith C, Kim SK, Lee EY, Kim SG, Kang KW (*equal contribution)

Molecular Pharmacology 2007;72(4):1082-93.

Role of hypoxia-inducible factor-alpha in hepatitis-B-virus X protein-mediated MDR1 activation.

Han HK*, Han CY*, Cheon EP, Lee J, Kang KW (*equal contribution)

Biochemical and Biophysical Research Communications 2007;357(2):567-73.